Advertisement

The Effects of Drugs and Steroid Hormones on the Enzymes of the Endoplasmic Reticulum

  • D. V. Parke
Chapter
Part of the Biological Council book series (BCSDA)

Abstract

The endoplasmic reticulum is the intracellular location of many diverse enzyme activities including several concerned with carbohydrate metabolism, e.g. glucose-6-phosphatase and glucuronyl transferase, and with protein synthesis. This subcellular structure is, however, more widely associated with the activities of the mixed function oxidases, enzyme(s) requiring reduced nicotinamide adenine dinucleotide phosphate (NADPH2) and molecular oxygen for activity, and concerned with the oxidative metabolism of drugs, steroids and other hormones, with the biosynthesis of cholesterol [1, 2] and its catabolism to the bile acids [3, 4], the ω-oxidation of fatty acids [5, 6], and the oxidation of prostaglandins [7].

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Bloch, K.; Science, N.Y.; 150, (1965) 19.CrossRefGoogle Scholar
  2. 2.
    Scallen, T. J., Dean, W. J. and Schuster, M. W.; J. biol. Chem.; 234, (1968) 5502.Google Scholar
  3. 3.
    Danielsson, H., Einarsson, K. and Johansson, G.; Eur. J. Biochem.; 2, (1967) 44.CrossRefPubMedGoogle Scholar
  4. 4.
    Wada, F., Hirata, K., Nakao, K. and Sakamoto, Y.; J. Biochem., Tokyo; 66, (1969) 699.Google Scholar
  5. 5.
    Preiss, B. and Bloch, K.; J. biol. Chem.; 239, (1964) 85.PubMedGoogle Scholar
  6. 6.
    Bjorkhem, I. and Danielsson, H.; Eur. J. Biochem.; 14, (1970) 473.CrossRefPubMedGoogle Scholar
  7. 7.
    Israelsson, U., Hamberg, M. and Samuelsson, B.; Eur. J. Biochem.; 11, (1969) 390.CrossRefPubMedGoogle Scholar
  8. 8.
    Parke, D. V.; The Biochemistry of Foreign Compounds; International series of Monographs in Pure and Applied Biology. Oxford: Pergamon Press, (1968).Google Scholar
  9. 9.
    Parke, D. V.; The metabolism of drugs; In: ‘Recent Advances in Pharmacology’; Eds J. M. Robson and R. S. Stacey. Churchill, London. 4th ed. (1968) p. 29.Google Scholar
  10. 10.
    Remmer, H., Schenkman, J., Estabrook, R. W., Sasame, H., Gillette, J., Narasimhulu, S., Cooper, D. Y. and Rosenthal, O.; Molec. Pharmac.; 2, (1966) 187.Google Scholar
  11. 11.
    Sladek, N. E. and Mannering, G. J.; Biochem. biophys. Res. Commun.; 24, (1966) 668.CrossRefPubMedGoogle Scholar
  12. 12.
    Gillette, J. R., Kamm, J. J. and Sasame, H. A.; Molec. Pharmac.; 4, (1968) 541.Google Scholar
  13. 13.
    Walker, C. H.; Life Sci.; 8, (1969) 1111.CrossRefPubMedGoogle Scholar
  14. 14.
    Kuntzman, R., Lawrence, D. and Conney, A. H.; Molec. Pharmac.; 1, (1965) 163.Google Scholar
  15. 15.
    Conney, A. H.; Pharmac. Rev.; 19, (1967) 317.Google Scholar
  16. 16.
    Conney, A. H., Welch, R. M., Kuntzman, R. and Burns, J. J.; Clin. Pharmac. Ther.; 8, (1967) 2.CrossRefGoogle Scholar
  17. 17.
    Juchau, M. R., Cram, R. L., Plaa, G. L. and Fouts, J. R.; Biochem. Pharmac.; 14, (1965) 473.CrossRefGoogle Scholar
  18. 18.
    Nebert, D. W. and Gelboin, H. V.; J. biol. Chem.; 243, (1968) 6242 and 6250.Google Scholar
  19. 19.
    Kato, R. and Takanaka, A.; J. Biochem., Tokyo; 63, (1968) 406.Google Scholar
  20. 20.
    Leon, L. and Mitoma, C.; Biochem. Pharmac.; 19, (1970) 2317.Google Scholar
  21. 21.
    Feuer, G.; Can. J. Physiol. Pharmac.; 48, (1970) 232.CrossRefGoogle Scholar
  22. 22.
    Jori, A., Bianchetti, A., Prestini, P. E. and Gorathini, S.; Eur. J. Pharmac.; 9, (1970) 362.CrossRefGoogle Scholar
  23. 23.
    Parke, D. V. and Rahman, H.; Biochem. J.; 113, (1969) 12 P.CrossRefGoogle Scholar
  24. 24.
    Wade, A. E., Holl, J. E., Hilliard, C. C., Molton, E. and Greene, F. E.; Pharmacology; 1, (1968) 317.CrossRefPubMedGoogle Scholar
  25. 25.
    Wattenberg, L. W. and Leong, J. L.; Cancer Res.; 30, (1970) 1922.PubMedGoogle Scholar
  26. 26.
    Parke, D. V. and Rahman, H.; Biochem. J.; 119, (1970) 53 P.CrossRefGoogle Scholar
  27. 27.
    Ruddon, R. W. and Cohen, A. M.; Toxicol. Appl. Pharmac.; 16, (1970) 613.CrossRefGoogle Scholar
  28. 28.
    Beckett, A. H. and Triggs, E. J.; Nature, Lond.; 216, (1967) 587.CrossRefGoogle Scholar
  29. 29.
    Lieber, C. S. and DeCarli, L. M.; Science, N.Y.; 162, (1968) 417.CrossRefGoogle Scholar
  30. 30.
    Rubin, E., Bacchin, P., Gang, H. and Lieber, C. S.; Lab. Invest.; 22, (1970) 569.PubMedGoogle Scholar
  31. 31.
    Schuppel, R.; Naunyn-Schmiedebergs, Arch. exp. Path. Pharmak.; 265, (1969) 156.CrossRefGoogle Scholar
  32. 32.
    Lieber, C. S. and DeCarli, L. M.; Life Sci.; 9, (1970) 267.CrossRefGoogle Scholar
  33. 33.
    Lange, G.; Naunyn-Schmiedebergs Arch. exp. Path. Pharmak.; 257, (1967) 230.CrossRefGoogle Scholar
  34. 34.
    Creaven, P. J. and Parke, D. V.; Fed. Eur. Biochem. Soc. Second Meeting Absts.; 128, (1965) 88.Google Scholar
  35. 35.
    King, L. J., Parke, D. V., Turbert, H. and Wynne, D.; Fed. Eur. Biochem. Soc. Fifth Meeting Absts.; (1968) 39.Google Scholar
  36. 36.
    Daly, J., Jerina, D., Farnsworth, J. and Guroff, G.; Arch. Biochem. Biophys.; 131, (1969) 238.CrossRefPubMedGoogle Scholar
  37. 37.
    Rickert, D. E. and Fouts, J. R.; Biochem. Pharmac.; 19, (1970) 381.CrossRefGoogle Scholar
  38. 38.
    McMahon, R. E. and Sullivan, H. R.; Life Sci.; 5, (1966) 921.CrossRefPubMedGoogle Scholar
  39. 39.
    Feuer, G. and Granda, V.; Toxicol. Appl. Pharm.; 16, (1970) 626.CrossRefGoogle Scholar
  40. 40.
    Pandhi, P. N. and Baum, H.; Life Sci.; 9, (1970) 87.CrossRefPubMedGoogle Scholar
  41. 41.
    Crigler, J. F. Jr., and Gold, N. I.; J. clin. Invest.; 48, (1966) 42.CrossRefGoogle Scholar
  42. 42.
    Yeung, C. Y. and Field, C. E.; Lancet; 2, (1969) 135.CrossRefPubMedGoogle Scholar
  43. 43.
    Maurer, H. M., Wolff, J. A., Finster, M., Poppers, P. J., Pantuck, E., Kuntzman, R. and Conney, A.; Lancet; 2, (1968) 122.CrossRefPubMedGoogle Scholar
  44. 44.
    Tardiff, R. G. and Dubois, K. R.; Archs. int. Pharmacodyn. Ther.; 177, (1969) 445.Google Scholar
  45. 45.
    Conney, A. H. and Gilman, A. G.; J. biol. Chem.; 238, (1963) 3682.PubMedGoogle Scholar
  46. 46.
    Kato, R., Loeb, L. and Gelboin, H. V.; Biochem. Pharmac.; 14, (1965) 1164.Google Scholar
  47. 47.
    Orrenius, S., Ericson, J. E. and Ernster, L.; J. cell Biol.; 25, (1965) 627.CrossRefPubMedPubMedCentralGoogle Scholar
  48. 48.
    Gelboin, H. V., Wortham, J. S. and Wilson, R. G.; Nature, Lond.; 214, (1967) 281.CrossRefGoogle Scholar
  49. 49.
    Piper, W. N. and Bousquet, W. F.; Biochem. biophys. Res. Commun.; 33, (1968) 602.CrossRefPubMedGoogle Scholar
  50. 50.
    Ruddon, R. W. and Rainey, C. H.; Biochem. biophys. Res. Commun.; 40, (1970) 152.CrossRefPubMedGoogle Scholar
  51. 51.
    Wold, J. W. and Steele, W. J.; Fed. Proc. Fedn. Am. Socs. exp. Biol.; 28, (1969) 484.Google Scholar
  52. 52.
    Nebert, D. W. and Bausserman, L. L.; Molec. Pharmac.; 6, (1970) 293.Google Scholar
  53. 53.
    Nebert, D. W. and Gelboin, H. V.; J. biol. Chem.; 245, (1970) 160.PubMedGoogle Scholar
  54. 54.
    Stolman, S. and Lou, H. H.; J. Pharm. Pharmac.; 22, (1970) 713.CrossRefGoogle Scholar
  55. 55.
    Louis-Ferdinand, R. T. and Fuller, G. C.; Biochem. biophys. Res. Commun.; 38, (1970) 811.CrossRefPubMedGoogle Scholar
  56. 56.
    Holtzman; J. L. and Gillette, J. R.; Biochem. biophys. Res. Commun.; 24, (1966) 639.CrossRefPubMedGoogle Scholar
  57. 57.
    Holtzman, J. L.; Biochem. Pharmac.; 18, (1969) 2573.CrossRefGoogle Scholar
  58. 58.
    Kuriyama, Y., Omura, T., Siekevitz, P. and Palade, G. E.; J. biol. Chem.; 244, (1969) 2017.PubMedGoogle Scholar
  59. 59.
    Raisfeld, I. H., Bacchin, P., Hutterer, F. and Schaffner, F.; Molec. Pharmac.; 6, (1970) 231.Google Scholar
  60. 60.
    Alvares, A. P., Schilling, G. R., Levin, W. and Kuntzman, R.; Biochem. biophys. Res. Commun.; 29, (1967) 521.CrossRefPubMedGoogle Scholar
  61. 61.
    Alvares, A. P. and Mannering, G. J.; Fed. Proc.; 26, (1967) 462.Google Scholar
  62. 62.
    Alvares, A. P., Shilling, G. R. and Kuntzman, R.; Biochem. biophys. Res. Commun.; 30, (1968) 588.CrossRefPubMedGoogle Scholar
  63. 63.
    Netter, K. J. and Seidel, G.; J. Pharmac. exp. Ther.; 146, (1964) 61.Google Scholar
  64. 64.
    Rubin, A., Tephly, T. R. and Mannering, G. J.; Biochem. Pharmac.; 13, (1964) 1007.Google Scholar
  65. 65.
    Bresnick, E. and Mosse, H.; Molec. Pharmac.; 5, (1969) 219.Google Scholar
  66. 66.
    Kato, R. and Takanaka, A.; Jap. J. Pharmac.; 19, (1969) 171.CrossRefGoogle Scholar
  67. 67.
    Shoeman, D. W., Chaplin, M. D. and Mannering, G. J.; Molec. Pharmac.; 5, (1969) 412.Google Scholar
  68. 68.
    Levin, W. and Kuntzman, R.; J. biol. Chem.; 244, (1969) 3671.PubMedGoogle Scholar
  69. 69.
    Murphy, P. J., Van Frank, R. M. and Williams, T. L.; Biochem. biophys. Res. Commun.; 37, (1969) 697.CrossRefPubMedGoogle Scholar
  70. 70.
    Rahman, H. and Parke, D. V.; Biochem. J.; 123, (1971) 9.Google Scholar
  71. 71.
    Yamamoto, S., Lin, K. and Bloch, K.; Proc. Nat. Acad. Sci. U.S.A.; 63, (1969) 110.CrossRefGoogle Scholar
  72. 72.
    Gaylor, J. L. and Mason, H. S.; J. biol. Chem.; 243, (1968) 4966.PubMedGoogle Scholar
  73. 73.
    Inano, H., Inano, A. and Tamaoki, B.-I.; Biochim. biophys. Acta.; 191, (1969) 257.CrossRefPubMedGoogle Scholar
  74. 74.
    Estabrook, R. W., Cooper, D. Y. and Rosenthal, O.; Biochem. Z.; 338, (1963) 741.PubMedGoogle Scholar
  75. 75.
    Wilson, L. D., Harding, B. W. and Nelson, D. H.; Biochim. biophys. Acta.; 99, (1965) 391.CrossRefPubMedGoogle Scholar
  76. 76.
    Bryson, M. J. and Sweat, M. L.; J. biol. Chem.; 243, (1968) 2799.Google Scholar
  77. 77.
    Matthijssen, C. and Mandel, J. E.; Biochim. biophys. Acta.; 146, (1967) 613.CrossRefPubMedGoogle Scholar
  78. 78.
    Matthijssen, C. and Mandel, J. E.; Steroids; 15, (1970) 541.CrossRefPubMedGoogle Scholar
  79. 79.
    Burnstein, S.; Biochem. biophys. Res. Commun.; 26, (1967) 697.CrossRefGoogle Scholar
  80. 80.
    Gustafsson, J. A., Lisboa, B. P. and Sjovall, J.; Eur. J. Biochem.; 5, (1968) 437.CrossRefPubMedGoogle Scholar
  81. 81.
    Gustafsson, J. A. and Lisboa, B. P.; Steroids; 14, (1969) 659.CrossRefPubMedGoogle Scholar
  82. 82.
    Voight, W., Thomas, P. J. and Hsia, S. L.; J. biol. Chem.; 243, (1968) 3493.Google Scholar
  83. 83.
    Hutterer, F., Denk, H., Bacchin, P. G., Schenkman, J. B., Schaffner, F. and Popper, H.; Life Sci.; 9, (1970) 877.CrossRefGoogle Scholar
  84. 84.
    Ryan, K. J.; J. biol. Chem.; 234, (1959) 268.PubMedGoogle Scholar
  85. 85.
    Axelrod, L. R., Matthijssen, C., Rao, P. N. and Goldzieher, J. W.; Acta. endocr.; 48, (1965) 383.PubMedGoogle Scholar
  86. 86.
    Fishman, J. and Dixon, D.; Biochemistry, N.Y.; 6, (1967) 1683.CrossRefGoogle Scholar
  87. 87.
    Meigs, R. A. and Ryan, K. J.; Biochim. biophys. Acta.; 165, (1968) 476.CrossRefPubMedGoogle Scholar
  88. 88.
    Mirkin, B. L.; Ann. Rev. Pharmac.; 10, (1970) 255.CrossRefGoogle Scholar
  89. 89.
    Chakraborty, J., Hopkins, R. and Parke, D. V.; Biochem. J.; (1971) in press.Google Scholar
  90. 90.
    Kato, R., Vassanelli, P. and Chiesara, E.; Biochem. Pharmac.; 12, (1963) 349.CrossRefGoogle Scholar
  91. 91.
    Mitoma, C., Yasuda, D., Tagg, J. S., Neubauer, S. E., Calderoni, F. J. and Tanabe, M.; Biochem. Pharma.; 17, (1968) 1377.CrossRefGoogle Scholar
  92. 92.
    Kato, R., Onoda, K. and Omori, Y.; Jap. J. Pharmac.; 18, (1968) 514.CrossRefGoogle Scholar
  93. 93.
    Wada, F., Hirata, K., Shibota, H., Higashi, K. and Sakamoto, Y.; J. Biochem., Tokyo; 62, (1967) 134.Google Scholar
  94. 94.
    Salvador, R. A., Atkins, C., Haber, S. and Conney, A. H.; Biochem. Pharmac.; 19, (1970) 1463.CrossRefGoogle Scholar
  95. 95.
    Salvador, R. A., Atkins, C., Haber, S., Kozma, C. and Conney, A. H.; Biochem. Pharmac.; 19, (1970) 1975.CrossRefGoogle Scholar
  96. 96.
    Astrup, P., Kjeldsen, K. and Wanstrup, J.; J. Atheroscler, Res.; 7, (1967) 343.CrossRefGoogle Scholar
  97. 97.
    Shefer, S., Hauser, S. and Mosbach, E. H.; J. Lipid Res.; 9, (1968) 328.PubMedGoogle Scholar
  98. 98.
    Einarsson, K. and Johansson, G.; Eur. J. Biochem.; 6, (1968) 293.CrossRefPubMedGoogle Scholar
  99. 99.
    Einarsson, K. and Johansson, G.; FEBS Letters; 4, (1969) 177.CrossRefPubMedGoogle Scholar
  100. 100.
    Johansson, G.; Biochem. Pharmac.; 19, (1970) 2817.CrossRefGoogle Scholar
  101. 101.
    Merola, A. J. and Arnold, A.; Science; 144, (1964) 301.CrossRefPubMedGoogle Scholar
  102. 102.
    Merola, A. J., Dill, R. R. and Arnold, A.; Arch. Biochem. Biophys.; 123, (1968) 378.CrossRefPubMedGoogle Scholar
  103. 103.
    Kritchevsky, D., Staple, E., Rabinowitz, J. L. and Whitehouse, M. W.; J. Lipid Res.; 4, (1963) 188.PubMedGoogle Scholar
  104. 104.
    Saini, V. C. and Patrick, S. J.;Biochim. biophys. Acta.; 202, (1970) 556.CrossRefGoogle Scholar
  105. 105.
    Burnstein, S., Kimball, H. L., Klaiber, E. L. and Gut, M.; J. clin. Endocr. Metab.; 27, (1967) 49.Google Scholar
  106. 106.
    Kupfer, D. and Peets, L.; Experientia; 24, (1968) 893.CrossRefPubMedGoogle Scholar
  107. 107.
    Conney, A. H., Jacobson, M., Schneidman, K. and Kuntzman, R.; Life Sci.; 4, (1965) 1091.Google Scholar
  108. 108.
    Burnstein, S. and Bhavani, B. R.; Endocrinology; 80, (1967) 351.CrossRefGoogle Scholar
  109. 109.
    Southern, A. L., Tochimoto, S., Strom, L., Ratuschni, A., Ross, H. and Gordon, G.; J. clin. Endocr. Metab.; 26, (1966) 268.CrossRefGoogle Scholar
  110. 110.
    Kuntzman, R., Jacobson, M., Levin, W. and Conney, A. H.; Biochem. Pharmac.; 17, (1968) 565.CrossRefGoogle Scholar
  111. 111.
    Bledsoe, T., Island, D. P., Ney, R. L. and Liddle, G. W.; J. clin. Endocr.; 24, (1964) 1303.Google Scholar
  112. 112.
    Kupfer, D. and Peets, L.; Biochem. Pharmac.; 15, (1966) 573.CrossRefGoogle Scholar
  113. 113.
    Conney, A. H. and Klutch, A.; J. biol. Chem.; 238, (1963) 1611.PubMedGoogle Scholar
  114. 114.
    Kuntzman, R., Levin, W., Jacobson, M. and Conney, A.; Life Sci.; 7, 215.Google Scholar
  115. 115.
    Welch, R. M., Levin, W. and Conney, A. H.; J. Pharm. exp. Ther.; 155, (1967) 167.Google Scholar
  116. 116.
    Kuntzman, R., Levin, W., Jacobson, M. and Conney, A. H.; Life Sci.; 7, (1968) 215.CrossRefGoogle Scholar
  117. 117.
    Heinricks, W. L. and Colas, A.; Biochemistry, N.Y.; 7, (1968) 2273.CrossRefGoogle Scholar
  118. 118.
    von Bahr, C., Lisboa, B. P. and ‘Orrenius,’ S.; Naunyn-Schmiedebergs Arch. exp. Path. Pharmak.; 264, (1969) 420.CrossRefGoogle Scholar
  119. 119.
    Levin, W., Welch, R. M. and Conney, A. H.; J. Pharmac. exp. Ther.; 159, (1968) 362.Google Scholar
  120. 120.
    Watanabe, H.; Steroids; 13, (1969) 189.CrossRefPubMedGoogle Scholar
  121. 121.
    Fumer, R. L. and Stitzel, R. E.; Biochem. Pharmac.; 17, (1968) 121.CrossRefGoogle Scholar
  122. 122.
    Driever, C. W. and Bousquet, W. F.; Life Sci.; 4, (1965) 1449.CrossRefPubMedGoogle Scholar
  123. 123.
    Castro, J. A., Greene, F. E., Gigon, P., Sasame, H. and Gillette, J. R.; Biochem. Pharmac.; 19, (1970) 2461.CrossRefGoogle Scholar
  124. 124.
    Radzialowski, F. M. and Bousquet, W. F.; J. Pharmac. exp. Ther.; 163, (1968) 229.Google Scholar
  125. 125.
    Sarkar, N. S.; FEBS Letters; 4, (1969) 37.CrossRefPubMedGoogle Scholar
  126. 126.
    Sluyser, M.; Biochim. biophys. Acta.; 182, (1969) 235.CrossRefPubMedGoogle Scholar
  127. 127.
    James, D. W., Rabin, B. R. and Williams, D. J.; Nature, Lond.; 224, (1969) 371.CrossRefGoogle Scholar
  128. 128.
    Gessner, T., Acara, M., Baker, J. A. and Edelman, L. L.; J. pharm. Sci.; 56, (1967) 405.CrossRefGoogle Scholar
  129. 129.
    Novick, W. J. Jr., Stohler, C. M. and Swagzdis, J.; J. Pharm. exp. Ther.; 151, (1966) 139.Google Scholar
  130. 130.
    Gerald, M. C. and Feller, D. R.; Biochem. Pharmac.; 19, (1970) 2529.Google Scholar
  131. 131.
    Solymoss, B., Varga, S. and Classen, H. G.; Eur. J. Pharmac.; 10, (1970) 127.CrossRefGoogle Scholar
  132. 132.
    Solymoss, B., Krajny, M., Varga, S. and Werringloer, J.; J. Pharmac. exp. Ther.; 174, (1970) 473.Google Scholar
  133. 133.
    Tephly, T. R. and Mannering, G. J.; Molec. Pharmac.; 4, (1968) 10.Google Scholar
  134. 134.
    Wada, F., Shimakawa, H., Takasugi, M., Kotake, T. and Sakamoto, Y.; J. Biochem., Tokyo; 64, (1968) 109.Google Scholar
  135. 135.
    Leibman, K. C.; Molec. Pharmac.; 5, (1969) 1.Google Scholar
  136. 136.
    Hayakawa, T., Kanai, N., Yamada, R., Kuroda, R., Higashi, H., Mogami, H. and Jinnai, D.; Biochem. Pharmac.; 18, (1969) 129.CrossRefGoogle Scholar
  137. 137.
    Tochino, Y., Iwata, T. and Mineshita, T.; Folia pharmac. Jap.; 62, (1966) 152.CrossRefGoogle Scholar
  138. 138.
    Crawford, J. S. and Rudofsky, S.; Brit. J. Anaesth.; 38, (1966) 446.CrossRefPubMedGoogle Scholar
  139. 139.
    Short, R. V.; In: ‘Hormones in Blood’; Eds C. H. Gray and A. L. Bacherach. Academic Press, N.Y. (1961).Google Scholar
  140. 140.
    Hashimoto, I., Henricks, D. M., Anderson, L. L. and Melampy, R. M.; Endocrinology; 82, (1968) 333.CrossRefPubMedGoogle Scholar
  141. 141.
    Cessi, C.; Boll. Soc. ital. Biol. sper.; 28, (1952) 1857.PubMedGoogle Scholar
  142. 142.
    Lathe, G. H. and Walker, M.; Biochem. J.; 68, (1958) 6 P.Google Scholar
  143. 143.
    Hsia, D. Y. Y., Dowben, R. M., Shaw, R and Grossman, A.; Nature, Lond.; 187, (1960) 693.CrossRefGoogle Scholar
  144. 144.
    Lauritzen, Ch. and Lehmann, W. D.; J. Endocrin.; 39, (1967) 183.CrossRefGoogle Scholar
  145. 145.
    Arias, I. M. and Gartner, L.; Nature, Lond.; 203, (1964) 1292.CrossRefGoogle Scholar
  146. 146.
    Creaven, P. J. and Parke, D. V.; Fed. Eur. Biochem. Soc. Second Meeting Absts.; 128, (1965) 88.Google Scholar
  147. 147.
    Pulkkinen, M.; Acta. physiol. scand.; 66, (1966) 120.CrossRefPubMedGoogle Scholar
  148. 148.
    Neale, M. G. and Parke, D. V.; Biochem. J.; 113, (1969) 12 P.CrossRefGoogle Scholar
  149. 149.
    Guarino, A. M., Gram, T. E., Schroeder, D. H., Call, J. and Gillette, J. R.; J. Pharmac. exp. Ther.; 168, (1969) 224.Google Scholar
  150. 150.
    Juchau, M. R. and Fouts, J. R.; Biochem. Pharmac.; 15, (1966) 89.Google Scholar
  151. 151.
    Blackham, A. and Spencer, P. S. J.; Br. J. Pharmac.; 37, (1969) 129.CrossRefGoogle Scholar
  152. 152.
    Rümke, Chr. L. and Noordhock, J.; Eur J. Pharmac.; 6, (1969) 163.CrossRefGoogle Scholar
  153. 153.
    Jori, A., Bianchetti, A. and Prestini, P. E.; Eur. J. Pharmac.; 7, (1969) 196.CrossRefGoogle Scholar
  154. 154.
    Neale, M. G.; The Influence of pregnancy and oral contraceptive steroids on drug metabolism; Thesis, University of Surrey, (1970).Google Scholar

Copyright information

© Institute of Biology Endowment Fund 1971

Authors and Affiliations

  • D. V. Parke
    • 1
  1. 1.Department of BiochemistryUniversity of SurreyGuildford, SurreyU.K.

Personalised recommendations