Aflatoxin Carcinogenesis in Rats: Dietary Effects
Malnutrition and aflatoxins co-exist in many areas of the world where there is a high incidence of cirrhosis and primary hepatic carcinoma in native population groups.1–6 Despite the often referred to association between malnutrition, cirrhosis and liver carcinoma in man, relatively few reports have appeared in the literature describing experimental studies in animals. The early reports of Salmon et al.7 described the induction of nutritional cirrhosis in rats in which a significant number developed liver cell carcinoma. Later work8 indicated that cirrhosis was neither a necessary prerequisite nor concomitant to the development of liver cancer in rats exposed to aflatoxin although nutritional cirrhosis may modify the response under some conditions.9 Further work using chemically defined, purified amino acid diets10 has shown that nutritional cirrhosis alone is not sufficient to induce liver cell cancer in rats. In retrospect, it seems reasonable to assume that the diet of Salmon et al. was contaminated with aflatoxin and that cirrhosis was an additional complicating factor induced by the choline deficient diet possibly interacting with the carcinogen.
KeywordsToxicity Depression DMSO Adenoma Penicillin
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