Pharmacological characterisation ofcentral receptors for thermoregulation
Both acetylcholine and monoamines such as noradrenaline and 5-hydroxytryptamine have been implicated in the central regulation of body temperature. Feldberg and Myers (1964, 1965) postulated that the body temperature was achieved by a balance between the release of 5-hydroxytryptamine (5-HT) and noradrenaline in the preoptic area of the anterior hypothalamus (Cooper, Cranston and Honour, 1965; Feldberg, Hellon and Myers, 1966; Feldberg, Hellon and Lotti,1967). A hypothalamic cholinergic mechanism was, however, demonstrated to be involved in the control of body temperature in a number of species (Kirkpatrick, Lomax and Jenden, 1967; Bligh, Cottle and Maskrey, 1971; Myers and Beleslin, 1971a). Since thermal stimulation of the preoptic area can alter the neuronal activity in the caudal hypothalamus (Nutik, 1971) Myers (1971) suggested that the hypothalamic thermal regulation in primates involved an interaction between monoaminergic and cholinergic systems. The present study, therefore, was carried out to elucidate the nature of receptors concerned in the hypothalamic thermoregulation in rabbits and also to determine a possible interaction between them.
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