Role of Immune Reactions in Response to Toxic Metals
One of the earliest indications that toxic metals could cause tissue damage as a result of an immunological reaction comes from the observations of Jadassohn (1896). Jadassohn was a dermatologist who found that patients with dermatitis, following treatment with mercuric chloride, would react directly at the site of contact with this compound. This use of a localized ‘patch test’ to indicate a state of hypersensitivity to a simple chemical agent opened up the whole field of contact sensitivity, now known to be one of the most important forms of cell-mediated immune reactions. It is accepted now that contact sensitivity to simple chemical compounds is one of the major causes of industrial morbidity in our technicological society.
Unable to display preview. Download preview PDF.
- Chase, M. (1963). In La Tolérance Acquise et la Tolérance Naturelle à l’égard de Substances Antigéniques Définies, p. 139. Paris: CnrsGoogle Scholar
- Epstein, W. L. (1967). Progr. Allergy, 11, 36Google Scholar
- Jadassohn, J. (1896). Verh. d. Dtsch. Derm. Gesellschaft. V. Kongress, p. 103Google Scholar
- Landsteiner, K. (1945). The Specificity of Serological Reactions. Cambridge: Harvard University PressGoogle Scholar