Antimetabolic Action of 6-Aminonicotinamide on the Pentose Phosphate Pathway in the Brain

  • H. Herken
Chapter
Part of the Biological Council book series (BCSDA)

Abstract

In attempting to understand the mechanism by which a toxic agent interferes with the normal functioning of cells, studies may be carried out at at least three levels: (i) an anatomical level, with a description of the changes in tissues, cells or cell components; (ii) a chemical level, with cytochemical techniques used in situ or studies in vitro on separate cellular constituents; (iii) a genetical level, with a follow-up of the offspring of treated animals, or of treated cells. Though some poisons are equally toxic for all cells, most are more toxic for one type of cell than another. It is only by the use of several experimental systems, multicellular, single-cell or sub-cellular, that the reason for such differences can be discovered.

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References

  1. Ord, M. J. (1970). T. cell Sci., in the PressGoogle Scholar
  2. Ord, M. J. (1968). J. cell Sci., 3, 483PubMedGoogle Scholar
  3. Ord, M. J. (1968). J. cell Sci., 3, 81PubMedGoogle Scholar
  4. Ord, M. J. (1968). Exp. cell Res., 53, 73PubMedCrossRefGoogle Scholar
  5. Ord, M. J. & Bell, L. G. E. (1970). Nature, Land., 226, 854CrossRefGoogle Scholar

Copyright information

© Institute of Biology Endowment Fund 1971

Authors and Affiliations

  • H. Herken
    • 1
  1. 1.Institute of PharmacologyFree UniversityBerlinGermany

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