Cardioactive Steroids with Special Reference to Calcium

  • M. Reiter
Part of the Biological Council book series

Abstract

The similarity between the positive inotropic effects of cardioactive steroids and calcium ions on the heart muscle led Loewi (1918) to suggest that glycosides sensitize the heart to calcium. There is evidence that calcium ions play an important role in activating myofibril-ATPase, so such a sensitization could mean that the cardioactive steroids act directly on the contractile proteins and make them sensitive to calcium ions. Many investigations, however, show that the contractile proteins are not directly affected by the glycosides in a manner which could explain their inotropic action.

Keywords

Sucrose Adrenaline Glycoside Nism Ouabain 

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Copyright information

© Palgrave Macmillan, a division of Macmillan Publishers Limited 1970

Authors and Affiliations

  • M. Reiter
    • 1
  1. 1.Institut für PharmakologieToxikologie der Technischen HochschuleMünchenGermany

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