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Roles of the Choroid Plexus in Aging

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Role of the Choroid Plexus in Health and Disease

Part of the book series: Physiology in Health and Disease ((PIHD))

Abstract

The choroid plexus comprises of a monolayer of tightly connected epithelial cells that form an important physical, enzymatic, and immunologic barrier, called the blood–cerebrospinal fluid (CSF) barrier. It is a highly vascularized structure located in the brain ventricles and plays a key role in maintaining brain homeostasis by producing CSF.

During aging, the morphology and normal function of the choroid plexus is compromised. Different alterations of the choroid plexus have been reported such as atrophy of the choroid plexus epithelial cells, decreased CSF production and secretion, decreased CSF clearance and absorption resulting in reduced clearance of toxic compounds, reduced enzymatic and metabolic activity, loss of barrier integrity, and insufficient distribution of nutrients. The described degeneration of the structure and function of the choroid plexus can result in multiple brain deficits and contribute to cognitive deterioration. In fact, these alterations of the choroid plexus are even more prominent in age-related neurodegenerative diseases including late-onset Alzheimer’s disease. A better understanding of the alterations in structure, activity, and function of the choroid plexus epithelial cells during aging and how the choroid plexus is implicated in aging and age-associated neurological diseases might reveal novel strategies to combat age-related cognitive decline and age-related neurological disorders.

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Authors and Affiliations

  1. VIB Center for Inflammation Research, Ghent, Belgium

    Caroline Van Cauwenberghe, Nina Gorlé & Roosmarijn E. Vandenbroucke

  2. Barriers in Inflammation Lab, Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium

    Caroline Van Cauwenberghe, Nina Gorlé & Roosmarijn E. Vandenbroucke

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  1. Caroline Van Cauwenberghe
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  2. Nina Gorlé
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  3. Roosmarijn E. Vandenbroucke
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Correspondence to Roosmarijn E. Vandenbroucke .

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  1. Department of Biomedicine, Faculty of Health, Aarhus University, Aarhus, Denmark

    Jeppe Praetorius

  2. Department of Biology, Indiana University – Purdue University Indianapolis, Indianapolis, IN, USA

    Bonnie Blazer-Yost

  3. Department of Biomedicine, Faculty of Health, Aarhus University, Aarhus, Denmark

    Helle Damkier

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Van Cauwenberghe, C., Gorlé, N., Vandenbroucke, R.E. (2020). Roles of the Choroid Plexus in Aging. In: Praetorius, J., Blazer-Yost, B., Damkier, H. (eds) Role of the Choroid Plexus in Health and Disease. Physiology in Health and Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-0716-0536-3_9

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