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Lymphomas of the Testis in Elderly Patients

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Book cover Management of Urological Cancers in Older People

Part of the book series: Management of Cancer in Older People ((volume 1))

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Abstract

Primary testicular lymphoma (PTL) is the most common malignant testicular tumor in men older than 50 years. Among them, diffuse large B-cell subtype is the most frequent. Other lymphoma subtypes are very rare. Typical clinical presentation is a painless unilateral testicular mass. Constitutional symptoms such as fever, weight loss, anorexia, and night sweats are rare at diagnosis. Treatment is complex and requires a multidisciplinary approach. The therapeutic strategy will be dependent on the initial characteristics of the patient, particularly the International Prognostic Index (IPI) including characteristics of the tumor (stage, histology) and characteristics of the patients (performance status, age, and comorbidity). The orchidectomy will provide the diagnosis and is part of the treatment. The specificity of the outcome of PTL-DLBCL is a high risk of extranodal relapse, particularly CNS relapse and contralateral testis, even in cases with localized disease at diagnosis. These particular features remain the most therapeutic challenges in the treatment of PTL. Therefore, management of the patients should be carefully discussed in terms of adjuvant therapy after orchidectomy, including immunotherapy with R-CHOP or R-CHOP-like regimen, CNS prophylaxis, and radiotherapy for the opposite testis.

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Author information

Authors and Affiliations

  1. Department of Hemato-Oncology, Hôpital Saint-Louis, Paris, France

    Catherine Thieblemont M.D., Ph.D.

  2. Department of Pathology, Hôpital Saint-Louis, Paris, France

    Claire Benet M.D. & Josette Briere M.D., Ph.D.

Authors
  1. Catherine Thieblemont M.D., Ph.D.
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  2. Claire Benet M.D.
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  3. Josette Briere M.D., Ph.D.
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Corresponding author

Correspondence to Catherine Thieblemont M.D., Ph.D. .

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Editors and Affiliations

  1. Lyon-RTH Laënnec School of Medicine, Lyon, France

    Jean-Pierre Droz

  2. University of Liverpool, St Helens Teach, Marshalls Cross Road, St Helens, WA9 3DA, United Kingdom

    Riccardo A. Audisio

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Thieblemont, C., Benet, C., Briere, J. (2013). Lymphomas of the Testis in Elderly Patients. In: Droz, JP., Audisio, R. (eds) Management of Urological Cancers in Older People. Management of Cancer in Older People, vol 1. Springer, London. https://doi.org/10.1007/978-0-85729-999-4_23

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  • DOI: https://doi.org/10.1007/978-0-85729-999-4_23

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  • Publisher Name: Springer, London

  • Print ISBN: 978-0-85729-986-4

  • Online ISBN: 978-0-85729-999-4

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