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The ‘Shared Epitope’, Proteus Haemolysin, Type XI Collagen and Rheumatoid Arthritis

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Abstract

The association between rheumatoid arthritis and some subtypes of HLA-DR4 is well known and a particular region of the DRβ1 chain, from positions 70–74 coding for amino acids Gln-Arg-Arg-Ala-Ala (QRRAA) and found in DRB1*0101 (DR1) and some DR4 subtypes DRB1*0404 (DW14) and DRB1*0405 (Dw15), has been identified as the molecular sequence responsible for the susceptibility to rheumatoid arthritis (Nepom et al. 1989).

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References

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Authors and Affiliations

  1. King’s College London Division of Life Sciences, UCH School of Medicine, Franklin-Wilkins Building 150 Stamford Street, London, SE1 8WA, UK

    Alan Ebringer B.Sc., M.D., FRCP, FRACP, FRCPath (Professor of Immunology King’s College London and Honorary Consultant Rheumatologist Middlesex Hospital)

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  1. Alan Ebringer B.Sc., M.D., FRCP, FRACP, FRCPath
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Ebringer, A. (2011). The ‘Shared Epitope’, Proteus Haemolysin, Type XI Collagen and Rheumatoid Arthritis. In: Rheumatoid Arthritis and Proteus. Springer, London. https://doi.org/10.1007/978-0-85729-950-5_13

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  • DOI: https://doi.org/10.1007/978-0-85729-950-5_13

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  • Publisher Name: Springer, London

  • Print ISBN: 978-0-85729-949-9

  • Online ISBN: 978-0-85729-950-5

  • eBook Packages: MedicineMedicine (R0)

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