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Pharmacology

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Pediatric Critical Care Study Guide

Abstract

Pharmacology is the study of exogenous chemicals including their actions on and movement throughout the body. As a science, it encompasses both pharmacodynamics and pharmacokinetics. Pharmacokinetics relates to the movement of chemical entities throughout the body. By understanding a medications pharmacokinetics, one understands what the body does to the drug. On the other hand pharmacodynamics is the science of what the drug does to the body or an infecting microorganism. Pharmacodynamics relates to the action of a drug in the body over a period of time. This chapter will also cover pharmaceutics, the science of pharmaceutical systems that focuses on drug preparations and dosage forms.

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  • Kohka H, Nishibori M, Iwagaki H, et al. Histamine is a potent inducer of IL-18 and IFN-γ in human peripheral blood mononuclear cells. J Immunol. 2000;164:6640–6.

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  • Landry Y, Gies JP. Drugs and their molecular targets: an updated overview. Fundam Clin Pharmacol. 2008;22:1–18.

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  • Leucuta SE, Vlase L. Pharmacokinetics and metabolic drug interactions. Curr Clin Pharmacol. 2006;1:5–20.

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  • Levitt DG. PKQuest_Java: free, interactive physiologically based pharmacokinetic software package and tutorial. BMC Res Notes. 2009;2:158.

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  • Muir KW. Glutamate-based therapeutic approaches: clinical trials with NMDA antagonists. Curr Opin Pharmacol. 2006;6:1–8.

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  • Nielsen HJ, Mynster T, Jensen S, et al. Effect of ranitidine on soluble interleukin-2 receptors and CD 8 molecule is in surgical patients. Br J Surg. 1994;81:1747–51.

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  • Taketomo CK, Hodding JH, Kraus DM, Taketomo CK, Hodding JH, Kraus DM, editors. Lexicomp’s pediatric dosage handbook. 15th ed. Hudson: Lexicomp, Inc; 2008.

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Correspondence to Steven E. Lucking M.D. .

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© 2012 Springer-Verlag London Limited

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Brummel, G.L., Lucking, S.E. (2012). Pharmacology. In: Lucking, S., Maffei, F., Tamburro, R., Thomas, N. (eds) Pediatric Critical Care Study Guide. Springer, London. https://doi.org/10.1007/978-0-85729-923-9_16

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  • DOI: https://doi.org/10.1007/978-0-85729-923-9_16

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  • Online ISBN: 978-0-85729-923-9

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