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Controversies in the Management of Gynecological Cancers pp 59–68Cite as

Chemotherapy and/or Targeted Therapies for Advanced Endometrial Cancer: Time to Rethink?

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Abstract

Chemotherapy has been the treatment for endometrial cancer over the last several decades. Recently targeted agents have been investigated in attempts to further individualize therapy. Perhaps, hormonal therapy can be seen as the first biological targeted agent followed by anti-VEGF agents and mTOR inhibitors. Chemotherapy continues to be the mainstay in the treatment of endometrial cancer despite the development of these novel agents. In the future, combining chemotherapy with targeted agents shows promise in improving progression-free survival in patients with endometrial cancer.

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Authors and Affiliations

  1. Internal Medicine, Section: Hematology/Oncology, University of Chicago, 5841 South Maryland Avenue, MC 2115, Chicago, IL, 60637-1470, USA

    Erica Stringer-Reasor MD & Gini Fleming MD

  2. Medical Oncology, Princess Margaret Hospital, 610 University Avenue, Toronto, ON, Canada

    Daliah Tsoref MBBS

  3. Department of Medicine, Princess Margaret Cancer Centre, 610 University Avenue, Toronto, ON, M5G 2M9, Canada

    Amit Oza MD (Lon), FRCP, FRCPC

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  1. Erica Stringer-Reasor MD
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  2. Gini Fleming MD
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  3. Daliah Tsoref MBBS
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  4. Amit Oza MD (Lon), FRCP, FRCPC
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Correspondence to Erica Stringer-Reasor MD .

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Editors and Affiliations

  1. UCL Cancer Institute, University College London, London, United Kingdom

    Jonathan A. Ledermann

  2. Radiation Oncology, Leiden University Medical Center, Leiden, The Netherlands

    Carien L. Creutzberg

  3. Royal Women’s Hospital, The University of Melbourne, Melbourne, Australia

    Michael A. Quinn

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Stringer-Reasor, E., Fleming, G., Tsoref, D., Oza, A. (2014). Chemotherapy and/or Targeted Therapies for Advanced Endometrial Cancer: Time to Rethink?. In: Ledermann, J., Creutzberg, C., Quinn, M. (eds) Controversies in the Management of Gynecological Cancers. Springer, London. https://doi.org/10.1007/978-0-85729-910-9_6

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