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Maternal Diet, Oocyte Nutrition and Metabolism, and Offspring Health

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Oogenesis

Abstract

Malnutrition (i.e., undernutrition and overnutrition) is a worldwide phenomenon that can affect mammalian oocyte developmental competence following fertilization, compromising the establishment of pregnancy. However, live birth is usually possible during maternal malnutrition even in extreme cases of undernutrition (i.e., anorexia nervosa) and overnutrition (i.e., morbid obesity). Several epidemiological and clinical studies in humans and experimental animal models have demonstrated that in utero development under nutritional stress can program the development of noncommunicable diseases (NCD) in adult life (e.g., diabetes, metabolic syndrome). Of further significance is the fact that malnutrition can also program the development of NCD in adulthood via changes on oocyte physiology before conception. This chapter focuses on the available evidence supporting this latter hypothesis.

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Acknowledgments

We are grateful for the financial support of the BBSRC, MRC, Gerald Kerkut Trust, and EU FP7 for funding of research in TPF’s laboratory. In addition, we acknowledge the support of the COST Action FA0702 “GEMINI” for the opportunity to discuss and share research ideas among scientists within this area.

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  1. Centre for Biological Sciences, Southampton General Hospital, University of Southampton, Mailpoint 840, Tremona Road, Southampton, Hampshire, SO16 6YD, UK

    Miguel A. Velazquez MVZ, M.Sc., Ph.D. & Tom P. Fleming B.Sc., Ph.D.

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  1. Miguel A. Velazquez MVZ, M.Sc., Ph.D.
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  2. Tom P. Fleming B.Sc., Ph.D.
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Correspondence to Tom P. Fleming B.Sc., Ph.D. .

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  1. BIOGENESI, Instituti Clinici Zucchi, Via Zucchi 24, Monza, 20900, Italy

    Giovanni Coticchio

  2. University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, 66160, USA

    David F. Albertini

  3. Ospedale S. Raffaele, Department of Ob/Gyn, University Vita-Salute, Via Olgettina 60, Milan, 20132, Italy

    Lucia De Santis

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Velazquez, M.A., Fleming, T.P. (2013). Maternal Diet, Oocyte Nutrition and Metabolism, and Offspring Health. In: Coticchio, G., Albertini, D., De Santis, L. (eds) Oogenesis. Springer, London. https://doi.org/10.1007/978-0-85729-826-3_22

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