Explication and Defense of Sampson’s Theory of Pathogenesis

  • Ronald E. Batt


In May 1927, at the 52nd annual meeting of the American Gynecological Society at Hot Springs, Virginia, Sampson stated: “At the meeting of the American Gynecological Society in 1921, the writer presented a paper1 on perforating hemorrhagic cysts of the ovary and their relation to pelvic adenomas of endometrial type…In view of the theories which have arisen to explain the origin of the peritoneal endometriosis associated with these cysts, the following quotation from that paper may be of interest.”2 “The question naturally arises: in what way do the contents of the cyst or ovary cause the development of these adenomas? Is it due to some specific irritant present in the cyst contents which stimulates the peritoneal endothelium to a metaplasia with the development of endometrial tissue typical both in structure and function? Some may assert that dormant endometrial epithelium may be present in the tissues soiled by the contents of the cyst and this is stimulated to further growth. It seems to me that the conditions found in many of these specimens are analogous to the implantation of ovarian papilloma or cancer on the peritoneal surfaces of the pelvis from the rupture of an ovarian tumor containing these growths.”3


Obstet Gynecol Fallopian Tube Endometrial Tissue Menstrual Blood Endometrial Cavity 
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© Springer-Verlag LondonLimited 2011

Authors and Affiliations

  • Ronald E. Batt
    • 1
  1. 1.State University of New York at BuffaloBuffaloUSA

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