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Lymphedema pp 167–182Cite as

Combined Role of Lymphoscintigraphy, X-Ray Computed Tomography, Magnetic Resonance Imaging, and Positron Emission Tomography in the Management of Lymphedematous Disease

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Abstract

Various imaging options exist for the evaluation of lymphedematous diseases. Although each imaging technique can be considered separately according to its principles and technical methodologies, the interface among these techniques has become indistinct in practice. Indeed, most of the apparatuses used today for lymphoscintigraphic (LySc) investigations utilize a combination of single photon emission computed tomography dual-headed devices (SPECT) with an X-ray computed tomography machine (CT or SPECT-CT). When positron emission tomography (PET) systems are considered, these are nearly always combined with CT devices. Although these CT scans may not conform to high radiological diagnostic standards, they allow easy fusion of the SPECT or PET images with other high-quality and high-resolution X-ray CT or magnetic resonance images, thus providing additional diagnostic data. The techniques can then be used in an orderly fashion.

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References

  1. Bourgeois P. Critical analysis of the literature on the lymphoscintigraphic investigations of the limb edemas. Eur J Lymphology Relat Probl. 1996;6:1-9.

    Google Scholar 

  2. Szuba A, Shin WS, Strauss HW, Rockson S. The third circulation: radionuclide lymphoscintigraphy in the evaluation of lymphedema. J Nucl Med. 2003;44:43-57.

    PubMed  Google Scholar 

  3. Scarsbrook AF, Ganeshan A, Bradley KM. Pearls and pitfalls of radionuclide imaging of the lymphatic system. Part 2: evaluation of extremity lymphoedema. Br J Radiol. 2007;80:219-226.

    Article  PubMed  CAS  Google Scholar 

  4. Pecking AP, Albérini JL, Wartski M, Edeline V, Cluzan RV. Relationship between lymphoscintigraphy and clinical findings in lower limb lymphedema: towards a comprehensive staging. Lymphology. 2008;41:1-10.

    PubMed  CAS  Google Scholar 

  5. Bourgeois P, Munck D, Becker C, Leduc O, Leduc A. Reevaluation of a three-phase lymphoscintigraphic investigation protocol for the lower limb-edemas. Eur J Lymphology Relat Probl. 1996;6:10-21.

    Google Scholar 

  6. Bourgeois P, Belgrado JP. Interest of lymphoscintigraphic investigations in the post-therapeutic upper limb edemas [abstract]. Eur J Nucl Med Mol Imaging. 2009;36:S215.

    Google Scholar 

  7. Li LY, Zhao QX, Luo WC. An analysis of 30 cases of chylothorax and chyloperitoneum [Article in Chinese]. Zhonghua Nei Ke Za Zhi. 1991;30:347-349, 382.

    PubMed  CAS  Google Scholar 

  8. Howarth D, Gloviczki P. Lymphoscintigraphy and lymphangiography of lymphangiectasia. J Nucl Med. 1998;39:1635-1638.

    PubMed  CAS  Google Scholar 

  9. Nishiyama Y, Yamamoto Y, Mori Y, et al. Usefulness of Technetium-99m human serum albumin lymphoscintigraphy in chyluria. Clin Nucl Med. 1998;23:429-431.

    Article  PubMed  CAS  Google Scholar 

  10. Pui MH, Yueh TC. Lymphoscintigraphy in chyluria, chyloperitoneum and chylothorax. J Nucl Med. 1998;39:1292-1296.

    PubMed  CAS  Google Scholar 

  11. Wells RG, Ruskin JA, Sty JR. Lymphoscintigraphy: lower extremity lymphangioma. Clin Nucl Med. 1986;11:523.

    Article  PubMed  CAS  Google Scholar 

  12. Boxen I, Zhang ZM, Filler RM. Lymphoscintigraphy for cystic hygroma. J Nucl Med. 1990;31:516-518.

    PubMed  CAS  Google Scholar 

  13. Okizaki A, Shuke N, Yamamoto W, et al. Protein-loss into retroperitoneal lymphangioma: demonstration by lymphoscintigraphy and blood-pool scintigraphy with Tc-99m-human serum albumin. Ann Nucl Med. 2000;14:131-134.

    Article  PubMed  CAS  Google Scholar 

  14. Kuang-Tao Y. Detection of chylothorax and cervical cystic hygroma in hydrops fetalis using lymphoscintigraphy. Clin Nucl Med. 2006;31:205-206.

    Article  PubMed  Google Scholar 

  15. Marotel M, Cluzan R, Pascot M, Ghabboun S, Alliot F, Lasry JL. CT findings in 150 cases of lower extremity lymphedema. J Radiol. 1998;79:1373-1378.

    PubMed  CAS  Google Scholar 

  16. Wunderbaldinger P, Paya K, Partik B, et al. CT and MR imaging of generalized cystic lymphangiomatosis in pediatric patients. AJR Am J Roentgenol. 2000;174:827-832.

    PubMed  CAS  Google Scholar 

  17. Witte CL, Witte MH, Unger EC, et al. Advances in imaging of lymph flow disorders. Radiographics. 2000;20:1697-1719.

    PubMed  CAS  Google Scholar 

  18. Pecking AP, Mechelany-Corone C, Pichon MF. 1959–1999: from serum markers to 18-FDG in oncology: the experience of the René-Huguenin Center [Article in French]. Pathol Biol (Paris). 2000;48:819-824.

    CAS  Google Scholar 

  19. Klerkx WM, Bax L, Veldhuis WB, et al. Detection of lymph node metastases by gadolinium-enhanced magnetic resonance imaging: systematic review and meta-analysis. J Natl Cancer Inst. 2010;102:244-253.

    Article  PubMed  Google Scholar 

  20. Lu Q, Xu J, Liu N. Chronic lower extremity lymphedema: a comparative study of high-resolution interstitial MR lymphangiography and heavily T2-weighted MRI. Eur J Radiol. 2010;73:365-373.

    Article  PubMed  Google Scholar 

  21. Liu N, Wang C, Sun M. Noncontrast three-dimensional magnetic resonance imaging vs lymphoscintigraphy in the evaluation of lymph circulation disorders: a comparative study. J Vasc Surg. 2005;41:69-75.

    Article  PubMed  Google Scholar 

  22. Liu NF, Lu Q, Jiang ZH, Wang CG, Zhou JG. Anatomic and functional evaluation of the lymphatics and lymph nodes in diagnosis of lymphatic circulation disorders with contrast magnetic resonance lymphangiography. J Vasc Surg. 2009;49:980-987.

    Article  PubMed  Google Scholar 

  23. Notohamiprodjo M, Baumeister RG, Jakobs TF, et al. MR-lymphangiography at 3.0 T – a feasibility study. Eur Radiol. 2009;19:2771-2778.

    Article  PubMed  Google Scholar 

  24. Lohrmann C, Foeldi E, Langer M. MR imaging of the lymphatic system in patients with lipedema and lipo-lymphedema. Microvasc Res. 2009;77:335-339.

    Article  PubMed  Google Scholar 

  25. Lohrmann C, Pache G, Felmerer G, Foeldi E, Schaefer O, Langer M. Post-traumatic edema of the lower extremities: evaluation of the lymphatic vessels with magnetic resonance lymphangiography. J Vasc Surg. 2009;49:417-423.

    Article  PubMed  Google Scholar 

  26. Molitch H, Unger E, Witte C, vanSonnenberg E. Percutaneous sclerotherapy of lymphangiomas. Radiology. 1995;194:343-347.

    PubMed  CAS  Google Scholar 

  27. Yu DX, Ma XX, Zhang XM, Wang Q, Li CF. Morphological features and clinical feasibility of thoracic duct: detection with nonenhanced magnetic resonance imaging at 3.0 T. J Magn Reson Imaging. 2010;32:94-100.

    Article  PubMed  Google Scholar 

  28. Lohrmann C, Foeldi E, Langer M. Assessment of the lymphatic system in patients with diffuse lymphangiomatosis by magnetic resonance imaging. Eur J Radiol. 2009 Nov 11. [Epub ahead of print].

    Google Scholar 

  29. Dubois J, Garel L. Imaging and therapeutic approach of hemangiomas and vascular malformations in the pediatric age group. Pediatr Radiol. 1999;29:879-893.

    Article  PubMed  CAS  Google Scholar 

  30. Kuhlman JE, Bouchardy L, Fishman EK, Zerhouni EA. CT and MR imaging evaluation of chest wall disorders. Radiographics. 1994;14:571-595.

    PubMed  CAS  Google Scholar 

  31. Bourgeois P, Leduc O, Belgrado JP, Leduc A. Scintigraphic investigations of the superficial lymphatic system: quantitative differences between intradermal and subcutaneous injections. Nucl Med Commun. 2009;30:270-274.

    Article  PubMed  Google Scholar 

  32. Lohrmann C, Felmerer G, Foeldi E, Bartholomä JP, Langer M. MR lymphangiography for the assessment of the lymphatic system in patients undergoing microsurgical reconstructions of lymphatic vessels. Microvasc Res. 2008;76:42-45.

    Article  PubMed  Google Scholar 

  33. Bourgeois P, Munck D, Sales F. Anomalies of thoracic lymph duct drainage demonstrated by lymphoscintigraphy and review of the literature about these anomalies. Eur J Surg Oncol. 2008;34:553-555.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Service of Nuclear Medicine, Institute Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium

    Pierre Bourgeois

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  1. Pierre Bourgeois
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Editors and Affiliations

  1. George Washington University, Washington D.C, Washington, USA

    Byung-Boong Lee

  2. School of Medicine, University of California, San Diego, La Jolla, 92037, California, USA

    John Bergan

  3. Falk Cardiovascular Research Center, Stanford University School of Medicine, Stanford, 94305, USA

    Stanley G. Rockson

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Bourgeois, P. (2011). Combined Role of Lymphoscintigraphy, X-Ray Computed Tomography, Magnetic Resonance Imaging, and Positron Emission Tomography in the Management of Lymphedematous Disease. In: Lee, BB., Bergan, J., Rockson, S. (eds) Lymphedema. Springer, London. https://doi.org/10.1007/978-0-85729-567-5_21

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  • DOI: https://doi.org/10.1007/978-0-85729-567-5_21

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  • Publisher Name: Springer, London

  • Print ISBN: 978-0-85729-566-8

  • Online ISBN: 978-0-85729-567-5

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