In the current era of practicing medicine, it has become increasingly more difficult for surgeons to become successful researchers. As Dr. Craig Kent summarized in his Keynote Address at the Fundamentals of Surgical Research Course in 2009, the challenges that surgeons face are numerous. Surgery requires continual practice and maintenance of sound surgical technique by doing surgery, a circumstance that does not allow for lengthy periods of protected time. Institutional culture disfavors research in surgery.
Genomics Proteomics Metabolomics Clinical research Translational research
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Transforming Translation-Harnessing Discovery for Patient and Public Benefit. Report of the Translational Research Working Group of the National Cancer Advisory Board. 2007.Google Scholar
Gerber DE, Minna JD. ALK inhibition for non-small cell lung cancer: from discovery to therapy in record time. Cancer Cell. 2010;18:548-551.PubMedCrossRefGoogle Scholar
Tusher VG, Tibshirani R, Chu G. Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci USA. 2001;98:5116-5121.PubMedCrossRefGoogle Scholar
Harring TR, Guiteau JJ, Nguyen NT, et al. Building a comprehensive genomic program for hepatocellular carcinoma. World J Surg. 2011; 35(8):1746-50Google Scholar
Dowell JA, Frost DC, Zhang J, Li L. Comparison of two-dimensional fractionation techniques for shotgun proteomics. Anal Chem. 2008;80:6715-6723.PubMedCrossRefGoogle Scholar
Nelson PR, O’Malley KA, Feezor RJ, et al. Genomic and proteomic determinants of lower extremity revascularization failure: rationale and study design. J Vasc Surg. 2007;45(suppl A):A82-A91.PubMedCrossRefGoogle Scholar
Tweedle EM, Khattak I, Ang CW, et al. Low molecular weight heat shock protein HSP27 is a prognostic indicator in rectal cancer but not colon cancer. Gut. 2010;59:1501-1510.PubMedCrossRefGoogle Scholar
Ren F, Wu H, Lei Y, et al. Quantitative proteomics identification of phosphoglycerate mutase 1 as a novel therapeutic target in hepatocellular carcinoma. Mol Cancer. 2010;9:81.PubMedCrossRefGoogle Scholar
Beger RD, Sun J, Schnackenberg LK. Metabolomics approaches for discovering biomarkers of drug-induecd hepatotoxicity and nephrotoxicity. Toxicol Appl Pharm. 2010;243:154-166.CrossRefGoogle Scholar
Cobb JP, Mindrinos MN, Miller-Graziano C, et al. Application of genome-wide expression analysis to human health and disease. PNAS. 2005;102(13):4801-4806.PubMedCrossRefGoogle Scholar
Hirschhorn JN, Lohmueller K, Byrne E, et al. A comprehensive review of genetic association studies. Genet Med. 2002;4(2):45-61.PubMedCrossRefGoogle Scholar
Hocquette JF. Where are we in genomics? J Physiol Pharmacol. 2005;56(Supp 3):37-70.PubMedGoogle Scholar
McDunn JE, Chung P, Laramie JM, et al. Surgical research review: physiologic genomics. Surgery. 2006;139(2):133-139.PubMedCrossRefGoogle Scholar