Reviewing the Literature, Developing a Hypothesis, Study Design
Rigorous research investigation requires a thorough review of the literature on the topic of interest. This promotes development of an original, relevant, and feasible hypothesis. Design of an optimal study to test the hypothesis then requires adequate power, freedom from bias, and conduct within a reasonable timeframe with resources available to the investigator.
KeywordsLiterature review Hypothesis Study design Power Bias Validity Alpha error Randomized trial
Financial Support: Indiana Genomics Initiative (INGEN) of Indiana University. INGEN is supported in part by Lilly Endowment Inc. (CMS).
I would like to thank Dr. Carl Schmidt, MD, MSCI, Assistant Professor Surgery, the Ohio State University, for his expertise and critical review of this chapter.
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