Skip to main content

Photodynamic Therapy

  • Chapter
  • First Online:
Lasers in Dermatology and Medicine

Abstract

Photodynamic therapy with ALA or MAL is an excellent treatment for multiple actinic keratoses

Large field photodynamic therapy can eradicate multiple actinic keratoses with a shorter downtime than 5-fluorouracil or imiquimod

Multiple large field photodynamic therapy sessions can delay the appearance of actinic keratoses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Taub AF. Photodynamic therapy for the treatment of acne: a pilot study. J Drugs Dermatol. 2004;3(6 Suppl):S10-S14.

    PubMed  Google Scholar 

  2. Kennedy JC, Pottier RH, Pross DC. Photodynamic therapy with endogenous protoporphyrin IX: basic principles and present clinical experience. J Photochem Photobiol B. 1990;6(1–2):143-148.

    Article  PubMed  CAS  Google Scholar 

  3. Kloek J, Akkermans W, van Beijersbergen Henegouwen GM. Derivatives of 5-aminolevulinic acid for photodynamic therapy: enzymatic conversion into protoporphyrin. Photochem Photobiol. 1998;67(1):150-154.

    Article  PubMed  CAS  Google Scholar 

  4. Piacquadio DJ, Chen DM, Farber HF, et al. Photodynamic therapy with aminolevulinic acid topical solution and visible blue light in the treatment of multiple actinic keratoses of the face and scalp: investigator-blinded, phase 3, multicenter trials. Arch Dermatol. 2004;140(1):41-46.

    Article  PubMed  CAS  Google Scholar 

  5. Touma D, Yaar M, Whitehead S, et al. A trial of short incubation, broad-area photodynamic therapy for facial actinic keratoses and diffuse photodamage. Arch Dermatol. 2004;140(1):33-40.

    Article  PubMed  CAS  Google Scholar 

  6. Wang I, Bendsoe N, Klinteberg CA, et al. Photodynamic therapy vs. cryosurgery of basal cell carcinomas: results of a phase III clinical trial. Br J Dermatol. 2001;144(4):832-840.

    Article  PubMed  CAS  Google Scholar 

  7. Pariser DM, Lowe NJ, Stewart DM, et al. Photodynamic therapy with topical methyl aminolevulinate for actinic keratosis: results of a prospective randomized multicenter trial. J Am Acad Dermatol. 2003;48(2):227-232.

    Article  PubMed  Google Scholar 

  8. Tarstedt M, Rosdahl I, Berne B, et al. A randomized multicenter study to compare two treatment regimes of topical methyl aminolevulinate (Metvix)-PDT in actinic keratosis of the face and scalp. Acta Derm Venereol. 2005;85:424-428.

    Article  PubMed  CAS  Google Scholar 

  9. Horn M, Wolf P, Wulf HC, et al. Topical methyl aminolaevulinate photodynamic therapy in patients with basal cell carcinoma prone to complications and poor cosmetic outcome with conventional treatment. Br J Dermatol. 2003;149(6):1242-1249.

    Article  PubMed  CAS  Google Scholar 

  10. Rhodes LE, de Rie M, Enstrom Y, et al. Photodynamic therapy using topical methyl aminolevulinate vs surgery for nodular basal cell carcinoma: results of a multicenter randomized prospective trial. Arch Dermatol. 2004;140(1):17-23.

    Article  PubMed  CAS  Google Scholar 

  11. Vinciullo C, Elliott T, Francis D, et al. Photodynamic therapy with topical methyl aminolaevulinate for ‘difficult-to-treat’ basal cell carcinoma. Br J Dermatol. 2005;152(4):765-772.

    Article  PubMed  CAS  Google Scholar 

  12. Basset-Seguin N, Ibbotson SH, Emtestam L, et al. MAL-PDT versus cryotherapy in primary sBCC: results of 48-month follow up. J Eur Acad Dermatol Venereol. 2005;19(Suppl 2):237.

    Google Scholar 

  13. Basset-Seguin N, Ibbotson SH, Emtestam L, et al. MAL-PDT versus cryotherapy in primary sBCC: results of 36 months follow-up. J Eur Acad Dermatol Venereol. 2004;18(Suppl 2):412.

    Google Scholar 

  14. Alexiades-Armenakas M. Long-pulsed dye laser-mediated photodynamic therapy combined with topical therapy for mild to severe comedonal, inflammatory, or cystic acne. J Drugs Dermatol. 2006;5(1):45-55.

    PubMed  Google Scholar 

  15. Wiegell SR, Wulf HC. Photodynamic therapy of acne vulgaris using methyl aminolaevulinate: a blinded, randomized, controlled trial. Br J Dermatol. 2006;154(5):969-976.

    Article  PubMed  CAS  Google Scholar 

  16. Gold M, Bridges TM, Bradshaw VL, et al. ALA-PDT and blue light therapy for hidradenitis suppurativa. J Drugs Dermatol. 2004;3(1 Suppl):S32-S35.

    PubMed  Google Scholar 

  17. Dover JS, Bhatia AC, Stewart B, et al. Topical 5-aminolevulinic acid combined with intense pulsed light in the treatment of photoaging. Arch Dermatol. 2005;141(10):1247-1252.

    Article  PubMed  Google Scholar 

  18. Alster TS, Tanzi EL, Welsh EC. Photorejuvenation of facial skin with topical 20% 5-aminolevulinic acid and intense pulsed light treatment: a split-face comparison study. J Drugs Dermatol. 2005;4(1):35-38.

    PubMed  Google Scholar 

  19. Alster TS, Tanzi EL. Photodynamic therapy with topical aminolevulinic acid and pulsed dye laser irradiation for sebaceous hyperplasia. J Drugs Dermatol. 2003;2(5):501-504.

    PubMed  Google Scholar 

  20. Horfelt C, Funk J, Frohm-Nilsson M, et al. Topical methyl aminolaevulinate photodynamic therapy for treatment of facial acne vulgaris: results of a randomized, controlled study. Br J Dermatol. 2006;155(3):608-613.

    Article  PubMed  CAS  Google Scholar 

  21. Wiegell SR, Wulf HC. Photodynamic therapy of acne vulgaris using 5-aminolevulinic acid versus methyl aminolevulinate. J Am Acad Dermatol. 2006;54(4):647-651.

    Article  PubMed  Google Scholar 

  22. Hongcharu W, Taylor CR, Chang Y, et al. Topical ALA-photodynamic therapy for the treatment of acne vulgaris. J Investig Dermatol. 2000;115(2):183-192.

    Article  PubMed  CAS  Google Scholar 

  23. Borelli C, Merk K, Schaller M, et al. In vivo porphyrin production by P. acnes in untreated acne patients and its modulation by acne treatment. Acta Derm Venereol. 2006;86(4):316-319.

    Article  PubMed  CAS  Google Scholar 

  24. Avram DK, Goldman MP. Effectiveness and safety of ALA-IPL in treating actinic keratoses and photodamage. J Drugs Dermatol. 2004;3(1 Suppl):S36-S39.

    PubMed  Google Scholar 

  25. Gold MH, Bradshaw VL, Boring MM, et al. Split-face comparison of photodynamic therapy with 5-aminolevulinic acid and intense pulsed light versus intense pulsed light alone for photodamage. Dermatol Surg. 2006;32(6):795-801. Discussion 801-803.

    Article  PubMed  CAS  Google Scholar 

  26. Brooke RC, Sinha A, Sidhu MK, et al. Histamine is released following aminolevulinic acid-photodynamic therapy of human skin and mediates an aminolevulinic acid dose-related immediate inflammatory response. J Invest Dermatol. 2006;126(10):2296-2301.

    Article  PubMed  CAS  Google Scholar 

  27. Katz BE, Truong S, Maiwald DC, et al. Efficacy of microdermabrasion preceding ALA application in reducing the incubation time of ALA in laser PDT. J Drugs Dermatol. 2007;6(2):140-142.

    PubMed  Google Scholar 

  28. Bissonnette R, Nigen S, Bolduc C, et al. Protection afforded by sunscreens containing inorganic sunscreening agents against blue light sensitivity induced by aminolevulinic acid. Dermatol Surg. 2008;34(11):1469-1476.

    Article  PubMed  CAS  Google Scholar 

  29. Goldman MP, Merial-Kieny C, Nocera T, et al. Comparative benefit of two thermal spring waters after photodynamic therapy procedure. J Cosmet Dermatol. 2007;6(1):31-35.

    Article  PubMed  Google Scholar 

  30. Misra A, Maybury K, Eltigani TA. Late erythema after photodynamic therapy to the face. Plast Reconstr Surg. 2006;117(7):2522-2523.

    Article  PubMed  CAS  Google Scholar 

  31. Harries MJ, Street G, Gilmour E, et al. Allergic contact dermatitis to methyl aminolevulinate (Metvix) cream used in photodynamic therapy. Photodermatol Photoimmunol Photomed. 2007;23(1):35-36.

    Article  PubMed  Google Scholar 

  32. Angell-Petersen E, Christensen C, Muller CR, et al. Phototoxic reaction and porphyrin fluorescence in skin after topical application of methyl aminolaevulinate. Br J Dermatol. 2007;156(2):301-307.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Robert Bissonnette .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2011 Springer-Verlag London Limited

About this chapter

Cite this chapter

Bissonnette, R. (2011). Photodynamic Therapy. In: Nouri, K. (eds) Lasers in Dermatology and Medicine. Springer, London. https://doi.org/10.1007/978-0-85729-281-0_18

Download citation

  • DOI: https://doi.org/10.1007/978-0-85729-281-0_18

  • Published:

  • Publisher Name: Springer, London

  • Print ISBN: 978-0-85729-280-3

  • Online ISBN: 978-0-85729-281-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics