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Quantification of Retinal Chromophores Through Autofluorescence Imaging to Identify Precursors of Age-Related Macular Degeneration

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Excursions in Harmonic Analysis, Volume 2

Part of the book series: Applied and Numerical Harmonic Analysis ((ANHA))

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Abstract

Agerelated macular degeneration is a common disease that impairs central vision. To better understand early disease progression, we quantified two families of retinal chromophores: macular pigments in retinal axons and rod photoreceptor rhodopsin, whose changes have been associated with age-related maculopathy progression. First, we introduced noninvasive multispectral fluorescence imaging of the human retina and quantified macular pigments from those multispectral image sets. Second, we modeled the brightening of the lipofuscin autofluorescence in confocal scanning laser ophthalmoscopy imaging sequences to map local rod rhodopsin density.

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Notes

  1. 1.

    Unless stated otherwise, images were derived from NEI cameras or modified from resources at the National Eye Institute (NEI) or the Canadian National Institute for the Blind (CNIB).

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Acknowledgment

The research was funded by intramural research funds from the National Institute of Child Health and Human Development, National Institutes of Health. M. E. is supported by the NIH/DFG Research Career Transition Awards Program (EH 405/1-1/575910). J.D. was supported by NSF (CBET0854233). E.J.K. is supported by the Alexander von Humboldt Foundation.

Author information

Authors and Affiliations

  1. Helmholtz Zentrum Munich, Institute of Biomathematics and Biometry, Neuherberg, Germany

    M. Ehler

  2. Mathematics Department, University of Maryland, College Park, MD, USA

    J. Dobrosotskaya

  3. Department of Mathematics, Technical University Berlin, Berlin, Germany

    E. J. King

  4. Section on Medical Biophysics, NICHD, National Institutes of Health, Bethesda, MD, USA

    R. F. Bonner

Authors
  1. M. Ehler
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  2. J. Dobrosotskaya
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  3. E. J. King
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  4. R. F. Bonner
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Corresponding author

Correspondence to M. Ehler .

Editor information

Editors and Affiliations

  1. , Department of Mathematics, University of Maryland, Norbert Wiener Center, College Park, 20742-0001, Maryland, USA

    Travis D. Andrews

  2. Norbert Wiener Center, Department of Mathematics, University of Maryland, College Park, 20742, Maryland, USA

    Radu Balan

  3. Department of Mathematics, University of Maryland, College Park, 20742-4015, Maryland, USA

    John J. Benedetto

  4. Department of Mathematics, University of Maryland, College Park, 20742-4015, Maryland, USA

    Wojciech Czaja

  5. , Department of Mathematics, University of Maryland, College Park, 20742, Maryland, USA

    Kasso A. Okoudjou

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Ehler, M., Dobrosotskaya, J., King, E.J., Bonner, R.F. (2013). Quantification of Retinal Chromophores Through Autofluorescence Imaging to Identify Precursors of Age-Related Macular Degeneration. In: Andrews, T., Balan, R., Benedetto, J., Czaja, W., Okoudjou, K. (eds) Excursions in Harmonic Analysis, Volume 2. Applied and Numerical Harmonic Analysis. Birkhäuser, Boston. https://doi.org/10.1007/978-0-8176-8379-5_18

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