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Limitation of Stunning in Dog Myocardium by the Nucleoside-Nucleotide Mixture OG-VI

  • Chapter
The Ischemic Heart

Part of the book series: Progress in Experimental Cardiology ((PREC,volume 1))

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Abstract

OG-VI improves mechanical and metabolic function in the stunned myocardium because it provides substrates for the adenine nucleotide biosynthesis. This solution can be used as an energy ameliorant for therapy of patients with ischemic heart disease.

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References

  1. Braunwald E, Kloner RA. 1982. The stunned myocardium: prolonged, postischemic ventricular dysfunction. Circulation 66:1146–1149.

    PubMed  CAS  Google Scholar 

  2. Kuprianov VV, Steinschneider AY, Ruuge EK, Smirnov VN, Saks VA. 1983. 31P-NMR spectrum of phosphocreatine: deuterium-induced splitting of the signal. Biochem Biophys Res Commun 114:1117–1125.

    Article  Google Scholar 

  3. Ichihara K, Abiko Y. 1984. Rebound recovery of myocardial creatine phosphate with reperfusion after ischemia. Am Heart J 108:1594–1597.

    Article  PubMed  CAS  Google Scholar 

  4. Reibel DK, Rovetto MJ. 1979. Myocardial adenosine salvage rates and restoration of ATP content following ischemia. Am J Physiol 237:H247–H252.

    PubMed  CAS  Google Scholar 

  5. Vary TC, Angelakos ET, Schaffer SW. 1979. Metabolism and irreversible ischemic tissue damage in isolated perfused rat heart. Circ Res 45:218–225.

    PubMed  CAS  Google Scholar 

  6. Greenfield RA, Swain JL. 1987. Disruption of myofibrillar energy use: dual mechanisms that may contribute to postischemic dysfunction in stunned myocardium. Circ Res 60:283–289.

    PubMed  CAS  Google Scholar 

  7. Nakai T, Kano S, Satoh K, Hoshi K, Ichihara K. 1996. Effects of adenine nucleotide analogues on myocardial dysfunction during reperfusion after ischemia in dogs. J Cardiovasc Pharmacol 28:264–270.

    Article  PubMed  CAS  Google Scholar 

  8. Ogoshi S, Iwasa M, Mizobuchi S, Iwasa Y, Martiz A, Tamiya T. 1990. Effect of a nucleoside and nucleotide mixture on protein metabolism in rats given total parenteral nutrition after 70% hepatectomy. In Tanaka T, Okada A (eds), Nutritional Support in Organ Failure. Amsterdam: Elsevier Science, pp. 309–317.

    Google Scholar 

  9. Ogoshi S, Mizobuchi S, Iwasa M, Tamiya T. 1989. Effect of a nucleoside-nucleotide mixture on protein metabolism in rats after seventy percent hepatectomy. Nutrition 5:173–178.

    PubMed  CAS  Google Scholar 

  10. Ogoshi S, Iwasa M, Kitagawa S, Ohmori Y, Mizobuchi S, Iwasa Y, Tamiya T. 1988. EEects of total parenteral nutrition with nucleoside and nucleotide mixture on D-galactosamine-induced liver injury in rats. J Parenter Enter Nutr 12:53–57.

    Article  CAS  Google Scholar 

  11. Satoh K, Nakai T, Hoshi K, Ichihara K. 1993. Limitation of stunning in dog myocardium by nucleoside and nucleotide mixture, OG-VI. Coronary Artery Dis 4:1007–1012.

    Article  CAS  Google Scholar 

  12. Kano S, Nakai T, Kohri H, Ichihara K. 1995. Effects of OG-VI, a nucleoside/nucleotide mixture, and its constituents on myocardial stunning in dogs. Coronary Artery Dis 6:811–818.

    Article  CAS  Google Scholar 

  13. Okazaki Y, Kano S, Ogoshi S, Ichihara K. 1997. Effects of OG-VI, a nucleoside/nucleotide mixture, on ischemic myocardial metabolism in dogs. Coronary Artery Dis 8:39–43.

    Article  CAS  Google Scholar 

  14. Jennings RB, Ganote CE. 1976. Mitochondrial structure and function in acute myocardial ischemic injury. Circ Res 38(Suppl 1):I80–I91.

    PubMed  CAS  Google Scholar 

  15. Swain JL, Hines JJ, Sabina RL, Holmes EW. 1982. Accelerated repleteion of ATP and GTP pools in postischemic canine myocardium using a precursor of purine de novo synthesis. Circ Res 51:102–105.

    PubMed  CAS  Google Scholar 

  16. Bolli R, Jeroudi MO, Pate1 BS, Aruoma OI, Halliwell B, Lai EK, MacCay PB. 1989. Marked reduction of free radical generation and contractile dysfunction by antioxidant therapy begun at the time of reperfusion. Circ Res 65:607–622.

    PubMed  CAS  Google Scholar 

  17. Bolli R. 1990. Mechanism of myocardial stunning. Circulation 82:723–738.

    PubMed  CAS  Google Scholar 

  18. Martin DW Jr. 1980. Metabolism of purine and pyrimidine nucleotides. In Harper HA, Rodwell VW, Mayes PA (eds), Review of Physiological Chemistry. Los Altos: Lange Medical Publications, pp. 440–459.

    Google Scholar 

  19. Sabina RL, Kernstine KH, Boyd RL, Holmes EW, Swain JL. 1982. Metabolism of 5-amino-4-imidazolecarboxamide riboside in cardiac and skeletal muscle. J Biol Chem 257:10178–10183.

    PubMed  CAS  Google Scholar 

  20. Miura R, Kano S, Nakai T, Satoh K, Ichihara K. 1987. Inhibitory effects of glibenclamide and pertussis toxin on the attenuation of ischemia-induced myocardial acidosis following ischemic preconditioning in dogs. Jpn Circ J 61:709–714.

    Article  Google Scholar 

  21. Kano S, Satoh K, Hoshi K, Ichihara K. In Press. Effects of OG-VI, a neucleoside/neucleotide mixture, on stunned Myocardium in dogs: Is the adenosine A1 receptor involved? Coronary Artery Dis 9.

    Google Scholar 

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Author information

Authors and Affiliations

  1. Hokkaido College of Pharmacy, Japan

    Seiichiro Kano, Tohru Nakai, Kumi Satoh & Katsuji Hoshi

  2. Nutrition Research Institute, Japan

    Hideaki Kohri

  3. Kochi Medical School, Japan

    Yasunaga Okazaki

  4. Asahikawa Medical College, Japan

    Kazuo Ichihara

Authors
  1. Seiichiro Kano
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  2. Yasunaga Okazaki
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  3. Tohru Nakai
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  4. Kumi Satoh
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  5. Katsuji Hoshi
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  6. Hideaki Kohri
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  7. Kazuo Ichihara
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Editor information

Editors and Affiliations

  1. Department of Medicine Aoto Hospital, Jikei University School of Medicine, Tokyo, Japan

    Seibu Mochizuki M.D., Ph.D. (Professor and Chairman) (Professor and Chairman)

  2. Department of Internal Medicine Aoto Hospital, Jikei University School of Medicine, Tokyo, Japan

    Nobuakira Takeda M.D., Ph.D. (Associate Professor) (Associate Professor)

  3. Jikei University School of Medicine, Tokyo, Japan

    Makoto Nagano M.D., Ph.D. (Professor-Emeritus) (Professor-Emeritus)

  4. MRC Group in Experimental Cardiology Institute of Cardiovascular Sciences St. Boniface General Hospital Research Centre Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Naranjan S. Dhalla Ph.D., M.D. (Hon.), D.Sc. (Hon.) (Distinguished Professor and Director) (Distinguished Professor and Director)

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© 1998 Kluwer Academic Publishers

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Kano, S. et al. (1998). Limitation of Stunning in Dog Myocardium by the Nucleoside-Nucleotide Mixture OG-VI. In: Mochizuki, S., Takeda, N., Nagano, M., Dhalla, N.S. (eds) The Ischemic Heart. Progress in Experimental Cardiology, vol 1. Springer, Boston, MA. https://doi.org/10.1007/978-0-585-39844-0_36

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  • DOI: https://doi.org/10.1007/978-0-585-39844-0_36

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-7923-8105-1

  • Online ISBN: 978-0-585-39844-0

  • eBook Packages: Springer Book Archive

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