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Manganese Superoxide Dismutase Induced by Extracellular Stress Enhances Myocardial Tolerance to Ischemia-Reperfusion

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The Ischemic Heart

Part of the book series: Progress in Experimental Cardiology ((PREC,volume 1))

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Abstract

In this chapter, we describe our recent findings showing that an intrinsic radical scavenger, manganese superoxide dismutase (Mn-SOD), is induced in cardiac myocytes in response to various external stresses, such as ischemic (hypoxic) preconditioning, heat shock, and α1-adrenergic stimulation. The induction of Mn-SOD is well correlated with the acquisition of tolerance to ischemia-reperfusion injury of the myocardium. Because inhibition of Mn-SOD induction abolishes the tolerance to ischemia-reperfusion, Mn-SOD plays a pivotal role as a rescue protein in cardiac myocytes, and the induction of Mn-SOD could be an adaptation mechanism against ischemic heart disease.

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Author information

Authors and Affiliations

  1. Osaka University Medical School, Japan

    Tsunehiko Kuzuya, Masashi Nishida, Shiro Hoshida, Nobushige Yamashita, Masatsugu Hori & Michihiko Tada

Authors
  1. Tsunehiko Kuzuya
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  2. Masashi Nishida
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  3. Shiro Hoshida
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  4. Nobushige Yamashita
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  5. Masatsugu Hori
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  6. Michihiko Tada
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Editor information

Editors and Affiliations

  1. Department of Medicine Aoto Hospital, Jikei University School of Medicine, Tokyo, Japan

    Seibu Mochizuki M.D., Ph.D. (Professor and Chairman) (Professor and Chairman)

  2. Department of Internal Medicine Aoto Hospital, Jikei University School of Medicine, Tokyo, Japan

    Nobuakira Takeda M.D., Ph.D. (Associate Professor) (Associate Professor)

  3. Jikei University School of Medicine, Tokyo, Japan

    Makoto Nagano M.D., Ph.D. (Professor-Emeritus) (Professor-Emeritus)

  4. MRC Group in Experimental Cardiology Institute of Cardiovascular Sciences St. Boniface General Hospital Research Centre Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Naranjan S. Dhalla Ph.D., M.D. (Hon.), D.Sc. (Hon.) (Distinguished Professor and Director) (Distinguished Professor and Director)

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© 1998 Kluwer Academic Publishers

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Kuzuya, T., Nishida, M., Hoshida, S., Yamashita, N., Hori, M., Tada, M. (1998). Manganese Superoxide Dismutase Induced by Extracellular Stress Enhances Myocardial Tolerance to Ischemia-Reperfusion. In: Mochizuki, S., Takeda, N., Nagano, M., Dhalla, N.S. (eds) The Ischemic Heart. Progress in Experimental Cardiology, vol 1. Springer, Boston, MA. https://doi.org/10.1007/978-0-585-39844-0_29

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  • DOI: https://doi.org/10.1007/978-0-585-39844-0_29

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-7923-8105-1

  • Online ISBN: 978-0-585-39844-0

  • eBook Packages: Springer Book Archive

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