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Death receptors and their ligands

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Book cover Apoptosis in Cardiac Biology

Part of the book series: Basic Science for the Cardiologist ((BASC,volume 5))

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Abstract

The identification and description of an intrinsic program of regulated cellular suicide or apoptosis was originally obtained from morphological analyses in developmental biology (76, 77). This program exists in all multicellular organisms, and genetic analyses in the nematode Caenorhabditis elegans identified three ced-genes (for C. elegans death) as basal, highly conserved components of this program, see (39, 57). In mammals, several structural and functional homologs of these ced-encoded proteins are involved in the apoptosis regulating complex formation at the outer mitochondrial membrane (Fig. 1), the apoptosome (56, 124), such as Apaf-1 (for “apoptosis protease activating factor”) or proteins of the Bcl-2 family (see chapter I.2.2). Another important discovery from C. elegans genetics was the identification of interleukin-lß-converting enzyme (ICE or caspase-1) as a functional homolog of the ced-3 gene product. This discovery triggered the identification of a whole cascade of caspases (for “cysteine-containing aspartic acid proteases”, see chapter I.3.1). This cascade is involved in the execution phase of apoptosis (164), and one source for activating the cascade is the mitochondrial apoptosome (Fig. 1).

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Authors and Affiliations

  1. Martin-Luther-Universität Halle-Wittenberg, Halle/Saale, Germany

    Jürgen Holtz M.D. & Dorothea Darmer Ph.D.

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  1. Jürgen Holtz M.D.
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  2. Dorothea Darmer Ph.D.
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  1. University of Regensburg, Germany

    Heribert Schunkert  & G. A. J. Riegger  & 

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© 2000 Kluwer Academic Publishers

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Holtz, J., Darmer, D. (2000). Death receptors and their ligands. In: Schunkert, H., Riegger, G.A.J. (eds) Apoptosis in Cardiac Biology. Basic Science for the Cardiologist, vol 5. Springer, Boston, MA. https://doi.org/10.1007/978-0-585-38143-5_1

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  • DOI: https://doi.org/10.1007/978-0-585-38143-5_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-7923-8648-3

  • Online ISBN: 978-0-585-38143-5

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