Abstract
Spontaneous breathing movements have been described in the fetal sheep, fetal baboon and the human fetus prior to birth. In the fetal lamb and baboon, breathing movements can be observed as electromyographic activity in the diaphragm coupled with negative changes in intratracheal pressure[1],[2]. Movements of the fetal chest wall and diaphragm can readily be seen with the use of real-time ultrasound in the human[3]. Although they do not regulate fetal oxygenation, fetal breathing movements are similar to postnatal respiratory activity in that they involve phrenic nerve firing and are modulated by a variety of chemical signals including hypoxia, hypercarbia and pharmacological agents such as opiates. However, the dynamics of fetal breathing movements are quite unique and very different from the postnatal breathing pattern.
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References
Dawes, G. S., H._E. Fox, M. B. Leduc, G. C. Liggins, and R. T. Richards. Respiratory movements and rapid eye movement sleep in the fetal lamb. J. Physiol. 220: 119–143, 1972.
Stark, R. I., S. S. Daniel, Y.-I. Kim, K. Leung, H. R. Rey, and P. J. Tropper. Patterns of development in fetal breathing activity in the latter third of gestation of the baboon. Early Hum. Dev. 32: 31–47, 1993.
Mulder, E. J. H., M. Boersma, M. Meeuse, M. Van Der Wal, E. Van De Weerd, and G. H. A. Visser. Patterns of breathing movements in the near-term human fetus: Relationship to behavioural states. Early Hum. Dev. 36: 127–135, 1994.
Szeto, H. H., P. Y. Cheng, J. A. Decena, D. L. Wu, Y. Cheng, and G. Dwyer. Fractal properties in fetal breathing dynamics. Am. J. Physiol. 263: R141–R147, 1992.
Szeto, H. H., P. Y. Cheng, J. A. Decena, D. L. Wu, Y. Cheng, and G. Dwyer. Developmental changes in continuity and stability of breathing in the fetal lamb. Am. J. Physiol. 262: R452–R458, 1992.
Rey, H. R., R. I. Stark, Y. I. Kim, S. S. Daniel, G. MacCarter, and L. S. James. Method for processing of fetal breathing epoch analysis: studies in the primate. IEEE Engineering in Medicine and Biology 8: 30–42, 1989.
Montroll, E. W. and M. F. Shlesinger. On 1/f noise and distributions with long tails. Proc. Natl. Acad. Sci. USA 79: 3380–3383, 1982.
Szeto, H. H., Y. S. Zhu, J. G. Umans, G. Dwyer, S. Clare, and J. Amione. Dual action of morphine on fetal breathing movements. J. Pharmacol. Exp. Ther. 245: 537–542, 1988.
Szeto, H. H., P. Y. Cheng, G. Dwyer, J. A. Decena. D. L. Wu, and Y. Cheng. Morphine-induced stimulation of fetal breathing: role of mupreceptors and central muscarinic pathways. Am. J. Physiol. 261: R344–R350, 1991.
Shinbrot, T., C. Grebogi, E. Ott, and J. A. Yorke. Using small perturbations to control chaos. Nature 363: 411–417, 1993.
Garfinkel, A., M. L. Spano, W. L. Ditto, and J. N. Weiss. Controlling cardiac chaos. Science 257: 1230–1235, 1992.
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© 1996 Plenum Press
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Szeto, H.H. (1996). Nonlinear Control of Breathing Activity in Early Development. In: Bioengineering Approaches to Pulmonary Physiology and Medicine. Springer, Boston, MA. https://doi.org/10.1007/978-0-585-34964-0_11
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DOI: https://doi.org/10.1007/978-0-585-34964-0_11
Publisher Name: Springer, Boston, MA
Print ISBN: 978-0-306-45370-0
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