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Trends in Immunosuppressive Therapy With Regard to Cytolytic Induction Therapy and Corticosteroid Withdrawal

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The Transplantation and Replacement of Thoracic Organs

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Abstract

A cytolytic agent (e.g. antilymphocyte serum) administered immediately after heart transplantation (HTx) is known as ‘induction’ therapy and is given in the hope of inducing graft tolerance[1]–[4]. The benefit of this form of therapy remains controversial, as no randomized studies have been performed. Forms of antilymphocyte sera include murine monoclonal antibody (OKT3), rabbit and equine antithymocyte globulin (ATG), and antilymphocyte globulin (ALG).

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Authors
  1. J. Kobashigawa
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Editor information

Editors and Affiliations

  1. Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston

    David K. C. Cooper MA, PhD, MD, MS, FRCS, FACC, FACS

  2. Oklahoma Medical Research Foundation, Oklahoma City, USA

    David K. C. Cooper MA, PhD, MD, MS, FRCS, FACC, FACS

  3. St Louis University Health Sciences Center, St Louis, USA

    Leslie W. Miller MD, FACC

  4. Washington University School of Medicine, St Louis, USA

    G. Alexander Patterson MD, FRCS(C), FACS

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© 1996 Kluwer Academic Publishers

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Kobashigawa, J. (1996). Trends in Immunosuppressive Therapy With Regard to Cytolytic Induction Therapy and Corticosteroid Withdrawal. In: Cooper, D.K.C., Miller, L.W., Patterson, G.A. (eds) The Transplantation and Replacement of Thoracic Organs. Springer, Dordrecht. https://doi.org/10.1007/978-0-585-34287-0_9

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  • DOI: https://doi.org/10.1007/978-0-585-34287-0_9

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-0-7923-8898-2

  • Online ISBN: 978-0-585-34287-0

  • eBook Packages: Springer Book Archive

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