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The Problem of Pulmonary Hypertension in the Potential Cardiac Transplant Recipient

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The Transplantation and Replacement of Thoracic Organs

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Abstract

Despite advances in perioperative management, right-sided circulatory failure (RSCF) remains a significant source of morbidity and mortality early after cardiac transplantation. Perioperative RSCF, while clearly multifactorial in nature, has traditionally been associated with pretransplant pulmonary hypertension, as suggested by elevated pulmonary hemodynamic indices revealed on pretransplant cardiac catheterization. While severely elevated values of such indices represent a contraindication to cardiac transplantation at many centers worldwide, there currently exist no standard guidelines regarding the validity and importance of these preoperative abnormalities for postoperative outcome. The purpose of this chapter is to review the problem of pulmonary hypertension and the potential cardiac transplant recipient - its diagnosis, management and manipulation, and long-term clinical significance.

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Authors
  1. J. M. Chen
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  2. R. E. Michler
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Editor information

Editors and Affiliations

  1. Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston

    David K. C. Cooper MA, PhD, MD, MS, FRCS, FACC, FACS

  2. Oklahoma Medical Research Foundation, Oklahoma City, USA

    David K. C. Cooper MA, PhD, MD, MS, FRCS, FACC, FACS

  3. St Louis University Health Sciences Center, St Louis, USA

    Leslie W. Miller MD, FACC

  4. Washington University School of Medicine, St Louis, USA

    G. Alexander Patterson MD, FRCS(C), FACS

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© 1996 Kluwer Academic Publishers

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Chen, J.M., Michler, R.E. (1996). The Problem of Pulmonary Hypertension in the Potential Cardiac Transplant Recipient. In: Cooper, D.K.C., Miller, L.W., Patterson, G.A. (eds) The Transplantation and Replacement of Thoracic Organs. Springer, Dordrecht. https://doi.org/10.1007/978-0-585-34287-0_20

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  • DOI: https://doi.org/10.1007/978-0-585-34287-0_20

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-0-7923-8898-2

  • Online ISBN: 978-0-585-34287-0

  • eBook Packages: Springer Book Archive

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