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Anticoagulation Monitoring for Percutaneous Transluminal Coronary Angioplasty

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Textbook of Coronary Thrombosis and Thrombolysis

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 193))

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Abstract

Percutaneous transluminal coronary angioplasty (PTCA) relieves coronary obstruction through mechanical disruption of atherosclerotic lesions. It results in focal, traumatic injury, and loss of endothelial integrity, and is an intense stimulus for the formation of thrombus. Thrombus formation at the site of injury may result in reocclusion of the treated vessel and is thought to be a major factor contributing to the process of restenosis. Evidence from the cardiopulmonary bypass literature provides a strong argument that the intensity of anticoagulation influences the frequency with which thrombotic complications may develop. A growing body of evidence suggests that this is true for catheter-based intervention as well. As a result, patients are routinely anticoagulated with intravenous heparin during and immediately after angioplasty, and the degree or intensity of anticoagulation is frequently monitored during PTCA. This chapter presents current views on monitoring the efficacy and adequacy of anticoagulation for catheter-based interventional procedures.

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  1. James J. Ferguson
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Editors and Affiliations

  1. Cardiovascular Thrombosis Research Center, USA

    Richard C. Becker M.D. (Director) (Director)

  2. Coronary Care Unit, University of Massachusetts Medical School, Worcester, Massachusetts

    Richard C. Becker M.D. (Director) (Director)

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Ferguson, J.J., Wilson, J.M. (1997). Anticoagulation Monitoring for Percutaneous Transluminal Coronary Angioplasty. In: Becker, R.C. (eds) Textbook of Coronary Thrombosis and Thrombolysis. Developments in Cardiovascular Medicine, vol 193. Springer, Boston, MA. https://doi.org/10.1007/978-0-585-33754-8_37

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