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Goals,Concepts,and Current State of the Retina Implant Project

Epi-Ret

  • Chapter
Retinal Degenerative Diseases and Experimental Therapy

Abstract

For blind subjects with retina degenerative diseases (especially: retinitis pigmentosa and macular degeneration) to regain visual perception, a team of 14 expert groups develops a partially implantable, learning visual prosthesis (retina implant). This team with experts from several biological, medical, and technological areas is supported by the German research ministry (BMBF) and is coordinated by the author. Retina implants consist of a learning retina encoder (RE)—to be mounted on a frame of glasses or embedded in a contact lens—for the approximate simulation of parts of the retina by transforming light patterns into impulse trains similar to the receptive field properties of ganglion cells, a microcontact foil as retina stimulator (RS) to be implanted adjacent to the ganglion cell layer, and a wireless signal- and energy transmission between RE and RS. The function of the various spatiotemporal filters of the RE, which is being implemented by learning neural nets, will be tuned individually in a dialog with the implant-carrying subject for optimal visual perception.

The development and successful test of retina implant prototypes in animals is expected at the end of the first 4-years research phase in 1999. In a subsequent research phase with participation from industry, the next step for adaptation of the retina implant system for application in humans and first trial tests with a small number of volunteers will follow. It is expected that implant-carrying subjects will be able to recognize position and ‘gestalt’ of larger objects (e.g. window, door, chair, table) based on RE and RS with about 500 microcontacts in connexion with retinal ganglion cells, and that they will be able to walk and orient themselves without help in most unknown environments. This hope is partly based on recent findings that simple gestalt perceptions could already be elicited in several blind subjects by temporary microstimulation of retinal ganglion cells. Furthermore, anatomical studies have recently shown that a significant portion of the ganglion cells and the optic nerve in this group of blind subjects remain intact, even though the layer of photoreceptors is degenerated.

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References

  1. DJ. D’Amico, 1994, Diseases of the retina, New England J. Med. 331:95–106.

    Article  CAS  Google Scholar 

  2. T.P. Dryja and E.L. Berson, 1995, Retinitis pigmentosa and allied diseases, Invest. Ophthal. & Vis. Sci. 36:1197–1200.

    CAS  Google Scholar 

  3. R.W. Massof and D. Finkelstein, 1987, A two-stage hypothesis for the natural course of retinitis pigmentosa”, in: Adv. in the Biosciences, Volume 62, pp. 29–58, Pergamon Press.

    Google Scholar 

  4. J.L. Stone, W.E. Barlow, M.S. Humayun, E. de Juan, A.H. Milam, and 1992, Morphometric analysis of macular photoreceptors and ganglion cells in retinas with retinitis pigmentosa. Arch. Ophthalmol. 110:1634–1639.

    PubMed  CAS  Google Scholar 

  5. M.S. Humayun, R.H. Propst, E. de Juan, K. McCormick, and D. Hickingbotham, 1994. Bipolar surface electrical stimulation of the vertebrate retina, Arch. Ophthal. 112:110–116.

    PubMed  CAS  Google Scholar 

  6. M.S. Humayun, E. de Juan, G. Dagnelie, R. Greenberg, and R. Propst, 1996, Artificial vision. Invest. Ophthal. & Vis. Sci. 37:S451.

    Google Scholar 

  7. J.F. Rizzo, S. Miller, T. Denison, T. Herndon, J.L. Wyatt, 1996, Electrically evoked cortical potentials from stimulation of rabbit retina with a microfabricated electrode array. Invest. Ophthal. & Vis. Sci. 37:S707.

    Google Scholar 

  8. M. Becker, M. Braun, and R. Eckmiller, 1998, Retina Implant adjustment with reinforcement learning, in: IEEE Int. Conf. Acustics, Speech, Signal Processing, ICASSP’ 98, Seattle, Volume 2, pp. 1181–1184.

    Google Scholar 

  9. R. Eckmiller, 1996, Concerning the development of retina implants with neural nets, in: Proc. Int. Conf. Neural Inf. Proc, ICONIPV6, Hong Kong, Vol. 1, pp. 21–28.

    Google Scholar 

  10. R. Eckmiller, 1997, Learning Retina Implants with epiretinal contacts. Ophthalmic Res. 29:281–289.

    Article  PubMed  CAS  Google Scholar 

  11. R. Hünermann, M. Becker, and R. Eckmiller, 1997, Towards real time implementation of a learning retina encoder, Invest. Ophthal. & Vis. Sci. 38(Suppl.):191.

    Google Scholar 

  12. H. Gerding, C. Uhlig, and U. Thelen, 1998, The retina implant project: development of techniques for implantation and epiretinal fixation of stimulators, Invest Ophthal. & Vis. Sci. 39(Suppl.):991.

    Google Scholar 

  13. W. Mokwa, H.K. Trieu, and L. Ewe, 1998, Implantable retina stimulator for a retina implant, in: EUF1T’ 98, Aachen, pp. 1788–1792.

    Google Scholar 

  14. N. Peixoto, S. Straburger, R. Hornig, P. Walter, P. Szurmann, and R. Eckmiller, 1998, Evaluation of implanted epiretinal microcontacts in the mammalian retina, Invest. Ophthal. & Vis. Sci. 39(Suppl.):902.

    Google Scholar 

  15. M. Schwarz, B.J. Hosticka, R. Hauschild, W. Mokwa, M. Scholles, and H.K. Trieu. 1996. Hardware architecture of a neural net based retina implant for patients suffering from retinitis pigmentosa. in: Proc. IEEE ICNN’96, Washington, pp. 653–658.

    Google Scholar 

  16. P. Walter, P. Szurmann, N. Peixoto, S. Stra burger, H.K. Trieu, L. Ewe, T. Stiglitz, J.U. Meyer, and K. Heimann, 1998, Evoked cortical potentials after electrical surface stimulation of the rabbits retina, Invest. Ophthal. & Vis. Sci. 39(Suppl.):990.

    Google Scholar 

  17. B.B. Lee, J. Pokorny, V.C. Smith, and J. Kremers, 1994, Responses to pulses and sinusoids in macaque ganglion cells. Vision Res. 34:3081–3096.

    Article  PubMed  CAS  Google Scholar 

  18. R.W. Rodieck, and M. Watanabe, 1993, Survey of the morphology of macaque retinal ganglion cells that project to the pretectum, superior colliculus, and parvicellular laminae of the lateral geniculate nucleus, J. Comp. Neurol. 338:289–303.

    Article  PubMed  CAS  Google Scholar 

  19. M. Watanabe and R.W. Rodieck, 1989, Parasol and midget ganglion cells of the primate retina, J. Comp. Neurol. 289:434–454.

    Article  PubMed  CAS  Google Scholar 

  20. T. Yeh, B.B. Lee and J. Kremers, 1996, The time course of adaptation in macaque retinal ganglion cells, Vision. Res. 36:913–931.

    Article  PubMed  CAS  Google Scholar 

  21. C.A. Curcio, K.R. Sloan, R.E. Kalina, A.E. Hendrickson, 1990, Human photoreceptor topography, J. Comp. Neurol. 292:497–523.

    Article  PubMed  CAS  Google Scholar 

  22. D.M. Dacey and M.R. Peterson, 1992, Dendritic field size and morphology of midget and parasol ganglion cells of the human retina, Proc. Natl. Acad. Sci. 89:9666–9670.

    Article  PubMed  CAS  Google Scholar 

  23. J.B. Jonas, U. Schneider, and O.H. Naumann, 1992, Count and density of human retinal photoreceptors, Graefes Arch. Clin. Exp. Ophthal. 230:505–510.

    CAS  Google Scholar 

  24. H. Kolb, 1994, The architecture of functional neural circuits in the vertebrate retina. Invest. Ophthal. & Vis. Sci. 35:2385–2404.

    CAS  Google Scholar 

  25. R. Eckmiller, 1975, Electronic simulation of the vertebrate retina. IEEE Trans. Biomed. Eng. BME-22:305–311.

    Article  Google Scholar 

  26. P. Gaudiano, 1992, Toward a unified theory of spatiotemporal processing in the retina, in: Neural Networks for Vision and Image Processing (G. Carpenter, S. Grossberg, eds.), pp. 195–220, MIT Press, Cambridge MA.

    Google Scholar 

  27. J. Bullier and L.G. Nowak, 1995, Parallel versus serial processing: New vistas on the distributed organization of the visual system, Curr. Opin. Neurobiol. 5:497–503.

    Article  PubMed  CAS  Google Scholar 

  28. R. Eckmiller, 1998, Lernfähiger sensomotorischer Encoder für Sehund Hörprothesen, International Patent Application with 28 claims, PCT/EP98/00968, 1998.

    Google Scholar 

  29. M. Meister, L. Lagnado, and D.A. Baylor, 1995, Concerted signaling by retinal ganglion cells, Science 270:1207–1210.

    Article  PubMed  CAS  Google Scholar 

  30. S. Neuenschwander, W. Singer, 1996, Long-range synchronization of oscillatory light responses in the cat retina and lateral geniculate nucleus, Nature 379:728–733.

    Article  PubMed  CAS  Google Scholar 

  31. R. Eckmiller and S. Suchert, in press, Strategy for the foundation of a neurotechnology complany, in: Int. Conf. Neural Inf. Proc., ICONIP’ 98, Kitakyushu, November 1998, 8 pages.

    Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Computer Science VI, University of Bonn, D-53117, Bonn, Germany

    Rolf Eckmiller

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  1. Rolf Eckmiller
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Editor information

Editors and Affiliations

  1. Cole Eye Institute, The Cleveland Clinic Foundation, Cleveland, Ohio

    Joe G. Hollyfield

  2. Dean A. McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma

    Robert E. Anderson

  3. Beckman Vision Center, University of California, San Francisco, San Francisco, California

    Matthew M. LaVail

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© 1999 Kluwer Academic / Plenum Publishers

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Eckmiller, R. (1999). Goals,Concepts,and Current State of the Retina Implant Project. In: Hollyfield, J.G., Anderson, R.E., LaVail, M.M. (eds) Retinal Degenerative Diseases and Experimental Therapy. Springer, Boston, MA. https://doi.org/10.1007/978-0-585-33172-0_46

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  • DOI: https://doi.org/10.1007/978-0-585-33172-0_46

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-46193-4

  • Online ISBN: 978-0-585-33172-0

  • eBook Packages: Springer Book Archive

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