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Age and Monocular Enucleation as Potential Determinants of Light Damage in the Mouse Retina

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Retinal Degenerative Diseases and Experimental Therapy

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Abstract

Age and monocular enucleation have been examined as potential determinants of the susceptibility of the retina to light damage. BALB/c and C57BL/6J -c 2J mice were examined. BALB/c mice showed an initial increase in susceptibility to light damage between 8.5–10 weeks of age. This did not coincide with the time of sexual maturation, as reported previously for the rat. C57BL/6J-C2J mice, which are significantly more resistant to light damage than most other albino strains, showed no age-related change in susceptibility. Monocular enucleation had no effect on the susceptibility of the intact eye to light damage in either strain.

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Authors and Affiliations

  1. Beckman Vision Center, University of California San Francisco, San Francisco, California, 94131-0730

    Matthew M. LaVail, Naveen N. Kumar, Gregg M. Gorrin, Douglas Yasumura & Michael T. Matthes

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  1. Matthew M. LaVail
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  2. Naveen N. Kumar
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  3. Gregg M. Gorrin
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  4. Douglas Yasumura
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  5. Michael T. Matthes
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Editor information

Editors and Affiliations

  1. Cole Eye Institute, The Cleveland Clinic Foundation, Cleveland, Ohio

    Joe G. Hollyfield

  2. Dean A. McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma

    Robert E. Anderson

  3. Beckman Vision Center, University of California, San Francisco, San Francisco, California

    Matthew M. LaVail

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© 1999 Kluwer Academic / Plenum Publishers

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LaVail, M.M., Kumar, N.N., Gorrin, G.M., Yasumura, D., Matthes, M.T. (1999). Age and Monocular Enucleation as Potential Determinants of Light Damage in the Mouse Retina. In: Hollyfield, J.G., Anderson, R.E., LaVail, M.M. (eds) Retinal Degenerative Diseases and Experimental Therapy. Springer, Boston, MA. https://doi.org/10.1007/978-0-585-33172-0_30

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  • DOI: https://doi.org/10.1007/978-0-585-33172-0_30

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-46193-4

  • Online ISBN: 978-0-585-33172-0

  • eBook Packages: Springer Book Archive

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