Skip to main content
SpringerLink
Log in

Electromagnetic Fields and Cellular Systems

Signal Transduction, Cell Growth and Proliferation

  • Chapter
  • First Online:
Biological Effects of Magnetic and Electromagnetic Fields

  • 271 Accesses

Introduction

This paper reviews some of the in vitro research conducted in our laboratory to identify cellular responses to ELF fields. Studies we have conducted support an interaction site involving ligand-receptor events such as antibody binding to its cell surface receptor since we have observed changes in receptor-initiated calcium influx in cells exposed to magnetic fields. These changes suggest that signal transduction (ST) which is initiated by ligand-receptor binding plays a role in this interaction. Others have also reported that ELF fields influence enzyme activation, gene expression, protein synthesis and cell proliferation, all of which are triggered by earlier ST events at the cell membrane.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Frey, A. Electromagnetic Field Interactions with Biological Systems, FASEB Journal (1993) 7; 272–281.

    Article  Google Scholar 

  2. Liburdy, R.P., ELF Fields and the Immune System: Signal Transduction, Calcium Metabolism, and Mitogenesis in Lymphocytes with Relevance to Carcinogenesis, In Interaction Mechanisms of Low-Level Electromagnetic Fields in Living Systems [Eds. B. Norden & C. Ramel], Oxford University Press, NY. NY, 1992, pp. 217–239.

    Google Scholar 

  3. Liburdy, R.P., Calcium Signaling in Lymphocytes and ELF Fields: Evidence for an Electric Field Metric and a Site of Interaction Involving the Calcium Ion Channel. FEBS Letters (1992) 301; 53–59.

    Article  Google Scholar 

  4. Luben, R.A., Effects of Low-Energy Electromagnetic Fields (EMF) on Signal Transduction by G Protein Linked Receptors, In Electricity and Magnetism in Biology & Medicine [Ed., M. Blank], San Francisco Press. San Francisco. 1993, pp. 57–62.

    Google Scholar 

  5. Tenforde, T.S., Biological Interactions of Extremely-Low-Frequency Electric and Magnetic Fields. Bioelectrochemistry and Bioenergetics (1991) 25: 1–17.

    Article  Google Scholar 

  6. Tenforde, T.S., Cellular and Molecular Pathways of Extremely Low Frequency Electromagnetic Field Interactions with Living Systems. In Electricity and Magnetism in Biology and Medicine [Ed. M. Blank]. San Francisco Press, San Francisco, CA, 1993, pp. 1–8.

    Google Scholar 

  7. Frey, A. [Editor] On The Nature of Electromagnetic Field Interactions With Biological Systems, R.I. Landes Company, Austin, TX, 1994.

    Google Scholar 

  8. Liburdy, R.P. Cellular Interactions with Electromagnetic Fields: Experimental Evidence for Field Effects on Signal Transduction and Cell Proliferation, In On The Nature of Electromagnetic Field Interactions With Biological Systems. [Ed. A. Frey] R.G. Landes Company, Austin, TX, 1994, pp. 99–125.

    Google Scholar 

  9. Morgan, N.G. Cell Signaling, The Guilford Press. NY. 1989.

    Google Scholar 

  10. Altman, A.T., Mustelin, K.M., Coggeshall, T., Lymphocyte Activation: A Biological Model of Signal Transduction. Crit. Rev. in Immunol. (1990) 10: 347–391.

    Google Scholar 

  11. Liburdy, R.P. & J. Walleczek, The Influence of Magnetic Fields on Calcium Metabolism in the Lymphocyte. Annual DOE Contractor’s Review, Portland, OR, 13–17 September. Abstract A2. 1989.

    Google Scholar 

  12. Walleczek, J. & R.P. Liburdy, Nonthermal 60 Hz Sinusoidal Magnetic-Field Exposure Enhances 45Ca2+ Uptake in Rat Thymocytes: Dependence on Mitogen Activation, FEBS Letters (1990) 271; 157–160.

    Article  Google Scholar 

  13. Yost, M.G. & Liburdy, R.P., Time-Varying and Static Magnetic Fields Act in Combination to Alter Calcium Signal Transduction in the Lymphocyte. FEBS Letters (1992) 296; 117–122.

    Article  Google Scholar 

  14. Scarfi, M.R., F. Bersani, A. Cossarizza, etal., 50 Hz AC Sinusoidal Electric Fields Do Not Exert Genotoxic Effects (Micronucleus Formation) in Human Lymphocytes, Radiation Research (1993), 135: 64–68.

    Article  ADS  Google Scholar 

  15. Liburdy, R.P., D.E. Callahan, J. Harland, et al.. Experimental Evidence for 60 Hz Magnetic Fields Operating Through the Signal Transduction Cascade: Effects on Calcium Influx and C-MYC mRNA Induction. FEBS Letters (1993) 334; 301–308.

    Article  Google Scholar 

  16. Liburdy, R.P., D.E. Callahan, T.R. Sloma. et al.. Intracellular Calcium. Calcium Transport, and cMYC mRNA Induction in Lymphocytes Exposed to 60 Hz Magnetic Fields: The Cell Membrane and the Signal Transduction Pathway, In Electricity and Magnetism in Biology and Medicine [Ed. M. Blank], San Francisco Press. San Francisco, CA. 1993. pp. 311–314.

    Google Scholar 

  17. Marcu, K.B., S.A. Bossome & A.J. Patel, MYC Function and Regulation. Annual Rev. Biochemistry (1992) 61: 809–860.

    Article  Google Scholar 

  18. Goodman, R. & A. Shirley-Henderson, Exposure of Human Cells to Electromagnetic Fields: Effect of Time and Field Strength on Transcript Levels, Electro-and Magnetobiology (1992) 11: 19–28.

    Article  Google Scholar 

  19. Blank, M., L. Soo, H. Lin, et al., Stimulation of Transcription in HL-60 Cells by Alternating Currents From Electric Fields, In Electricity and Magnetism in Biology and Medicine [Ed. M. Blank], San Francisco Press. San Francisco, CA, 1993, pp. 516–519.

    Google Scholar 

  20. Phillips, J.L.. W. Haggren, W.J. Thomas, et al., Magnetic Field Induced Changes in Specific Gene Transcription, Biochemiea et Biophysica Ada (1992) 1132; 140–144.

    Google Scholar 

  21. Stevens. R.G.. Electric Power Use and Breast Cancer: A Hypothesis. Am. J. F.pidemol. (1987) 125; 556–561.

    Article  Google Scholar 

  22. Tynes, T. & A. Andersen, Electromagnetic Fields and Male Breast Cancer, Lancet (1990) 336; 1596.

    Article  Google Scholar 

  23. Demers, P.A., D.B. Thomas, K.A. Rosenblatt, et al.. Occupational Exposure to Electromagnetic Fields and Breast Cancer in Men. Am. J. Epidemiol. (1991) 132; 775–776.

    Google Scholar 

  24. Matanoski, G.M., P.N. Breyese & E.A. Elliot, Electromagnetic Field Exposure and Male Breast Cancer, Lancet (1991) 33; 737.

    Article  Google Scholar 

  25. Liburdy, R.P.. T.R. Sloma, R. Sokolic, et al., ELF Magnetic Fields, Breast Cancer, and Melatonin: 60 Hz Fields Block Melatonin’s Oncostatic Action on ER+ Breast Cancer Cell Proliferation. J. Pineal Research., (1993) 14; 89–97.

    Article  Google Scholar 

  26. Blask, D.E., The Emerging Role of the Pineal Gland and Melatonin in Oncogenesis. In Extremely Low Frequency Electromagnetic Fields: The Question of Cancer [Eds. B.W. Wilson. R.G. Stevens. & L.E. Anderson], Battelle Press. Columbia Press, OH, 1990, pp. 319–325.

    Google Scholar 

  27. Wilson, B.W.. C.W. Wright. J.E. Morris, et al.. Evidence for an Effect of ELF Electromagnetic Fields on Human Pineal Gland Function, J. Pineal Research. (1990) 9; 259–269.

    Article  Google Scholar 

  28. Reiter, R.J., & B.A. Richardson, Magnetic Fields Effects on Pineal Indoleamine Metabolism and Possible Biological Consequences, FASEB J. (1990) 6; 2283–2287.

    Article  Google Scholar 

  29. Lerchl, A., K.O. Hanaka & R.J. Reiter, Pineal Gland Magnetosensitivity to Static Magnetic Fields is a Consequence of Induced Electric Currents (Eddy Currents), J. Pineal Research. (1991) 10; 108–116.

    Article  Google Scholar 

  30. Haggren, W., S.M. Yellon, J.L. Phillips, et al. Effect of Magnetic Field Exposure in Adult Djungarian Hamsters on Melatonin Rhythms and Molecular Markers, First World Congress form Electricity and Magnetism in Biology and Medicine, Lake Buena Vista, FL, June 14–19. Abstract P-l19, 1992.

    Google Scholar 

  31. Stevens, R.G., S. Davis, D.B. Thomas. L.E. Anderson & B.W. Wilson, Electric Power, Pineal Function, and the Risk of Breast Cancer, FASEB J. (1992) 6; 853–860.

    Article  Google Scholar 

  32. Reiter. R.J.. Changes in Circadian Melatonin Synthesis in the Pineal Gland of Animals Exposed to Extremely Low Frequency Electromagnetic Radiation: A Summary of Observations and Speculation on Their Implications, In Electromagnetic Fields and Circadian Rhvthmicity [Eds. M.C. Moore-Ede. S.S. Campbell & R.J. Reiter], Birkhauscr, Boston. 1992, pp. 13–17.

    Chapter  Google Scholar 

  33. Liburdy. R.P. Cell Culture Incubators. ELF Fields, and Important Considerations for Cell Culture Exposure and Propagation: An Exposure System for In Vitro Bioelectromagnetics Research. Bioelectromagnctics Society Meeting. Copenhagen, Denmark, June 12–17, 1994. Abstract P-198.

    Google Scholar 

  34. Cos. S. & Blask. D.E. Effects of the Pineal Hormone Melatonin in the Anchorage-Independent Growth of Human Breast Cancer Cells (MCF-7) in a Clonogenic Culture System. Cancer Letters (1990) 50; 115–119.

    Article  Google Scholar 

  35. L’Hermite-Baleriaux, M. & De Launoit, Y., Is Melatonin Really an In Vitro Inhibitor of Human Breast Cancer Cell Proliferation? In Vitro Dev. Biol. (1992) 28A; 583–584.

    Article  Google Scholar 

  36. Stuchly, M. A., D.W. Lecuyer & R.D. Mann, Extremely Low Frequency Electromagnetic Emissions form Video Display Terminals and Other Devices. Health Physics. (1983) 45: 713–722.

    Article  Google Scholar 

  37. Tenforde, T.S. & W.T. Kaune, Interaction of Extremely Low Frequency Electric and Magnetic Fields with Humans. Health Physics. (1987) 53; 585–606.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Life Sciences Division, Lawrence Berkeley Laboratory University of California, Berkeley, CA, 94720

    Robert P. Liburdy

Authors
  1. Robert P. Liburdy
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University of Tokyo, Tokyo, Japan

    Shoogo Ueno

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Plenum Press

About this chapter

Cite this chapter

Liburdy, R.P. (1996). Electromagnetic Fields and Cellular Systems. In: Ueno, S. (eds) Biological Effects of Magnetic and Electromagnetic Fields. Springer, New York, NY. https://doi.org/10.1007/978-0-585-31661-1_6

Download citation

  • DOI: https://doi.org/10.1007/978-0-585-31661-1_6

  • Published:

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-306-45292-5

  • Online ISBN: 978-0-585-31661-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation