Iatrogenic Models of Ischemic Heart Disease

  • David R. Gross


Ischemic heart disease is the most common cause of heart failure in humans. Ventricular dilation, hypertrophy, biochemical alterations, and edema formation are all consequences of the poor pumping capacity of the damaged myocardium. Two very different types of ischemia are studied. Global ischemia is associated with cardiac arrest usually iatrogenic during cardiopulmonary bypass surgery or from ventricular fibrillation although during the initial period of fibrillation coronary flow increases. Regional ischemia is associated with a localized myocardial infarction. The two types of ischemia differ significantly in their biochemical and electrophysiological characteristics.1


Leave Anterior Descend Ventricular Fibrillation Global Ischemia Regional Ischemia Proximal Leave Anterior Descend 
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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • David R. Gross
    • 1
  1. 1.Department of Veterinary BiosciencesUniversity of Illinois, Urbana Champaign College of Veterinary MedicineUrbanaUSA

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