Naturally Occurring, Iatrogenic and Transgenic Models of Atherosclerotic Disease

  • David R. Gross


Atherosclerosis in humans is a complex, multifactorial process usually occurring in large conduit arteries over prolonged periods of time. It is a chronic inflammatory disease, the result of interaction between atherogenic stimuli and the response of the arterial wall. Immune responses play a major role. There are predisposing genetic factors and a number of risk factors involved including hyperlipidemia, hypertension, obesity, smoking, and type-1 (insulin-dependent) and type-2 (noninsulin-dependent) diabetes.

Mouse models of atherosclerotic disease usually fail to mimic the cardiovascular complications of diabetes seen in humans. The Animal Models of Diabetic Complications Consortium, working under the auspices of the NIH, has been working to develop suitable mouse models and to standardize the methods used to assess metabolic and cardiovascular end points with the purpose of quantifying diabetes and its macrovascular complications. The consortium shares the animal models developed and the accumulation of phenotype information with scientists working in this area.1


Atherosclerotic Lesion Cholesteryl Ester Transfer Protein Cholesterol Ester Transfer Protein Total Plasma Cholesterol Level Atherosclerosis Research 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • David R. Gross
    • 1
  1. 1.Department of Veterinary BiosciencesUniversity of Illinois, Urbana Champaign College of Veterinary MedicineUrbanaUSA

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