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The Application of Tissue Autofluorescence in Detection and Management of Oral Cancer and Premalignant Lesions

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Optical Imaging of Cancer

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Abstract

There is a wealth of literature that supports the use of tissue autofluorescence in the screening and diagnosis of precancers in the lung, uterine cervix, skin, and oral cavity. This approach is already in clinical use in the lung, and the mechanism of action of tissue autofluorescence has been well described in the cervix. Data are now emerging supporting its clinical usage in the detection and management of oral cancer and premalignant lesions. In this chapter, we will describe the biology underlying tissue autofluorescence, briefly review its current application in the management of lung and cervical cancers, and finally focus on its potential clinical utility in the detection and management of oral cancer and premalignant lesions.

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Acknowledgments

The authors would like to acknowledge the funding support from the National Institute of Dental and Craniofacial Research (R01DE13124 and R01DE17013), from the Canadian Institutes of Health Research (MOP-77663), and from the Canadian Cancer Society (CSS-20336) and a Clinician Scientist Award from the Canadian Institutes of Health Research and Scholar Award from Michael Smith Foundation for Health Research (C.F. Poh).

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Authors and Affiliations

  1. Cancer Control Research and Cancer Imaging, BC Cancer Agency/Cancer Research Centre, University of British Columbia, Rm: JBM 322, 2199 Wesbrook Mall, V6T 1Z3, Vancouver, BC, Canada

    C.F. Poh (Faculty of Dentistry) & L. Zhang DMD, PhD (Faculty of Dentistry)

  2. Cancer Imaging, BC Cancer Agency/Cancer Research Centre, 675 West 10th Avenue, V5Z 1L3, Vancouver, BC, Canada

    P. Lane PhD & C. MacAulay PhD

  3. Cancer Control Research, BC Cancer Agency/Cancer Research Centre, Biomedical Physiology & Kinesiology, Simon Fraser University, 675 West 10th Avenue, V5Z 1L3, Vancouver, BC, Canada

    M.P. Rosin PhD

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  1. C.F. Poh
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Correspondence to C.F. Poh .

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  1. University of Alabama, Birmingham, 7th Avenue South 1808, Birmingham, 35294-0012, U.S.A.

    Eben Rosenthal

  2. Dept. Radiology, University of Alabama, Birmingham, 3rd Avenue South 1530, Birmingham, 35294-0012, U.S.A.

    Kurt R. Zinn

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Poh, C., Lane, P., MacAulay, C., Zhang, L., Rosin, M. (2010). The Application of Tissue Autofluorescence in Detection and Management of Oral Cancer and Premalignant Lesions. In: Rosenthal, E., Zinn, K. (eds) Optical Imaging of Cancer. Springer, New York, NY. https://doi.org/10.1007/978-0-387-93874-5_6

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