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Optical Imaging of Cancer pp 209–250Cite as

Optical Coherence Tomography for Cancer Detection

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Abstract

Optical coherence tomography (OCT) is an emerging high-resolution medical and biological imaging technology that is currently making the transition from the research lab into clinical practice. OCT is analogous to ultrasound B-mode imaging except that reflections of light are detected rather than sound. This technique is attractive for medical imaging because it permits real-time in situ imaging of tissue microstructure with resolution approaching that of conventional histology, but without the need for excision and histological processing. Although OCT penetration depth is on the order of 1–2 mm (Schmitt 1999), its fiber-optic implementation enables the use of compact endoscopic probes that facilitate internal access within the body, including epithelial layers, where 85% of all cancers originate (Gurjar et al. 2001).

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Acknowledgments

We wish to thank all the past and current members of the Biophotonics Imaging Laboratory at the Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, for their technical contributions and physical efforts toward the development and clinical translation of OCT and related optical biomedical imaging technologies. We also wish to thank all of our colleagues and collaborators that have advanced this field to the state of the art. We thank those that have contributed images and data and apologize to those who could not be represented due to limited publication space. The work from the Biophotonics Imaging Laboratory was supported in part by grants from the National Institutes of Health (Roadmap Initiative/NIBIB R21 EB005321, NIBIB R01 EB005221, NCI R21/R33 CA115536), the National Science Foundation (BES 03-47747, BES 05-19920), Carle Foundation Hospital, and the Grainger Foundation. Additional information can be found at http://biophotonics.illinois.edu.

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  1. Biophotonics Imaging Laboratory, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, 61801, Urbana, IL, USA

    Steven G. Adie PhD & Stephen A. Boppart

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  1. Steven G. Adie PhD
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  1. University of Alabama, Birmingham, 7th Avenue South 1808, Birmingham, 35294-0012, U.S.A.

    Eben Rosenthal

  2. Dept. Radiology, University of Alabama, Birmingham, 3rd Avenue South 1530, Birmingham, 35294-0012, U.S.A.

    Kurt R. Zinn

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Adie, S.G., Boppart, S.A. (2010). Optical Coherence Tomography for Cancer Detection. In: Rosenthal, E., Zinn, K. (eds) Optical Imaging of Cancer. Springer, New York, NY. https://doi.org/10.1007/978-0-387-93874-5_11

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