Sexual Transmission: Chlamydia trachomatis

  • Robert E. JohnsonEmail author
  • Stuart M. Berman
Part of the Statistics for Biology and Health book series (SBH)


Chlamydia trachomatis is an obligate intracellular Gram negative bacterium, which infects mucosal epithelial cells (Schachter and Stephens 2008). Chlamydia display a unique two-stage life cycle consisting of an infectious stage and a replicative stage. During the infectious stage the organism assumes a metabolically inactive form, the elementary body , which can survive in the host extracellular environment. Upon entry into a host cell the elementary body transforms within a host cell vacuole into a metabolically active, replicating form, the reticulate body. Over a period of approximately 36–72 hours of growth and replication, the reticulate bodies transform into infectious elementary bodies, which are extruded from the cell and repeat the cycle by infecting additional cells of the same or a second host.


Ectopic Pregnancy Chlamydia Trachomatis Pelvic Inflammatory diseasePelvic Inflammatory Disease Chlamydial Infection Sexual Partnership 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. Adams EJ, Turner KM, Edmunds WJ (2007) The cost effectiveness of opportunistic chlamydia screening in England. Sex Transm Infect 83:267–274CrossRefGoogle Scholar
  2. Andersen B, Gundgaard J, Kretzschmar M, Olsen J, Welte R, Oster-Gaard L (2006) Prediction of costs, effectiveness, and disease control of a population-based program using home sampling for diagnosis of urogenital Chlamydia trachomatis Infections. Sex Transm Dis 33:407–415CrossRefGoogle Scholar
  3. Arthur G, Lowndes CM, Blackham J, Fenton KA (2005) Divergent approaches to partner notification for sexually transmitted infections across the European Union. Sex Transm Dis 32:734–741CrossRefGoogle Scholar
  4. Bakken IJ (2008) Chlamydia trachomatis and ectopic pregnancy: recent epidemiological findings. Curr Opin Infect Dis 21:77–82CrossRefGoogle Scholar
  5. Berman SM, Ellen JM (2008) Adolescents and STDs, including HIV infection. In: Holmes KK, Sparling PF, Stamm WE, Piot P, Wasserheit JN, Corey L, Cohen MS, Watts DH (eds) Sexually Transmitted Diseases. McGraw-Hill, New York, pp 165–185Google Scholar
  6. Britton TF, DeLisle S, Fine D (1992) STDs and family planning clinics: a regional program for Chlamydia control that works. Am J Gynecol Health 6:80–87Google Scholar
  7. Brunham RC, Pourbohloul B, Mak S, White R, Rekart ML (2005) The unexpected impact of a Chlamydia trachomatis infection control program on susceptibility to reinfection. J Infect Dis 192:1836–1844CrossRefGoogle Scholar
  8. Centers for Disease Control and Prevention (1993) Recommendations for the prevention and management of Chlamydia trachomatis infections, 1993. MMWR Recomm Rep 42:1–39Google Scholar
  9. Centers for Disease Control and Prevention (1995) Ectopic pregnancy – United States, 1990–1992. MMWR Morb Mortal Wkly Rep 44:46–48Google Scholar
  10. Centers for Disease Control and Prevention (1998) Guidelines for treatment of sexually transmitted diseases 1998. MMWR Recomm Rep 47:1–111Google Scholar
  11. Centers for Disease Control and Prevention (2002) Sexually transmitted diseases treatment guidelines 2002. MMWR Recomm Rep 51:1–78Google Scholar
  12. Centers for Disease Control and Prevention (2006) Sexually transmitted diseases treatment guidelines, 2006. MMWR Recomm Rep 55:1–94Google Scholar
  13. Centers for Disease Control and Prevention (2008a) Recommendations for partner services programs for HIV infection, syphilis, gonorrhea, and chlamydial infection. MMWR Recomm Rep 57:1–83Google Scholar
  14. Centers for Disease Control and Prevention (2008b) Sexually transmitted disease surveillance, 2007. Atlanta, GA, U.S. Department of Health and Human ServicesGoogle Scholar
  15. Centers for Disease Control and Prevention (2009) Sexually transmitted disease surveillance 2007 supplement, chlamydia prevalence monitoring project annual report 2007. Atlanta, GA, U.S. Department of Health and Human ServicesGoogle Scholar
  16. Chaparro MV, Ghosh S, Nashed A, Poliak A (1978) Laparoscopy for the confirmation and prognostic evaluation of pelvic inflammatory disease. Int J Gynaecol Obstet 15:307–309Google Scholar
  17. Chen MY, Fairley CK, Donovan B (2005) Discordance between trends in chlamydia notifications and hospital admission rates for chlamydia related diseases in New South Wales, Australia. Sex Transm Infect 81:318–322CrossRefGoogle Scholar
  18. Coste J, Bouyer J, Ughetto S, Gerbaud L, Fernandez H, Pouly JL, Job-Spira N (2004) Ectopic pregnancy is again on the increase. Recent trends in the incidence of ectopic pregnancies in France (1992–2002). Hum Reprod 19:2014–2018CrossRefGoogle Scholar
  19. Coste J, Job-Spira N , ublet-Cuvelier B , Germain E , Glowaczower E , Fernandez H , Pouly JL (1994) Incidence of ectopic pregnancy. First results of a population-based register in France. Hum Reprod 9:742–745Google Scholar
  20. Coyne KM, Cohen CE, Smith NA, Mandalia S, Barton S (2007) Patient-delivered partner medication in the UK: an unlawful but popular choice. Int J STD AIDS 18:829–831CrossRefGoogle Scholar
  21. Datta SD, Sternberg M, Johnson RE, Berman S, Papp JR, McQuillan G, Weinstock H (2007) Gonorrhea and chlamydia in the United States among persons 14 to 39 years of age, 1999 to 2002. Ann Intern Med 147:89–96Google Scholar
  22. Datta, S. D., Sternberg, M., Satterwhite, C. L., Johnson, R., Papp, J., McQuillan, G., Berman, S.,, Weinstock, H (2008) Trends in chlamydia population prevalence in the US, 1999-2006. Results from the National Health and Nutrition Examination Survey (NHANES). Annual Meeting, Infectious Diseases Society of America, Washington DCGoogle Scholar
  23. Davies HD, Wang EE (1996) Periodic health examination, 1996 update: 2. Screening for chlamydial infections. Canadian Task Force on the Periodic Health Examination. CMAJ 154:1631–1644Google Scholar
  24. de Vries R, van Bergen JE, de Jong-van den Berg LT, Postma MJ, PILOT-CT Study Group (2008) Cost-utility of repeated screening for Chlamydia trachomatis. Value Health 11: 272–274Google Scholar
  25. de Vries R, van Bergen JE, de Jong-van den Berg LT, Postma MJ, PILOT-CT Study Group (2006) Systematic screening for Chlamydia trachomatis: estimating cost-effectiveness using dynamic modeling and Dutch data. Value Health 9:1–11Google Scholar
  26. den Hartog JE, Land JA, Stassen FR, Slobbe-van Drunen ME, Kessels AG, Bruggeman CA (2004) The role of chlamydia genus-specific and species-specific IgG antibody testing in predicting tubal disease in subfertile women. Hum Reprod 19:1380–1384CrossRefGoogle Scholar
  27. Doherty IA, Padian NS, Marlow C, Aral SO (2005) Determinants and consequences of sexual networks as they affect the spread of sexually transmitted infections. J Infect Dis 191 (suppl 1):S42–S54CrossRefGoogle Scholar
  28. Douglas JM (2008) Dear colleague: Announcing new national chlamydia screening coordinator. Division of STD Prevention, Centers for Disease Control and Prevention. Available at Accessed April 11, 2009
  29. Doxanakis A, Hayes RD, Chen MY, Gurrin LC, Hocking J, Bradshaw CS, Williams H, Fairley CK (2008) Missing pelvic inflammatory disease? Substantial differences in the rate at which doctors diagnose PID. Sex Transm Infect 84:518–523CrossRefGoogle Scholar
  30. Egger M, Low N, Smith GD, Lindblom B, Herrmann B (1998) Screening for chlamydial infections and the risk of ectopic pregnancy in a county in Sweden: ecological analysis. Brit Med J 316:1776–1780Google Scholar
  31. Farley TA, Cohen DA, Elkins W (2003) Asymptomatic sexually transmitted diseases: The case for screening. Prev Med 36:502–509CrossRefGoogle Scholar
  32. Farquhar CM (2005) Ectopic pregnancy. Lancet 366:583–591CrossRefGoogle Scholar
  33. Fenton KA, Korovessis C, Johnson AM, McCadden A, McManus S, Wellings K, Mercer CH, Carder C, Copas AJ, Nanchahal K, Macdowall W, Ridgway G, Field J, Erens B (2001) Sexual behaviour in Britain: reported sexually transmitted infections and prevalent genital Chlamydia trachomatis infection. Lancet 358:1851–1854CrossRefGoogle Scholar
  34. Fenton KA, Mercer CH, McManus S, Erens B, Wellings K, Macdowall W, Byron CL, Copas AJ, Nanchahal K, Field J, Johnson AM (2005) Ethnic variations in sexual behaviour in Great Britain and risk of sexually transmitted infections: a probability survey. Lancet 365:1246–1255CrossRefGoogle Scholar
  35. Fenton KA, Ward H (2004) National chlamydia screening programme in England: making progress. Sex Transm Infect 80:331–333CrossRefGoogle Scholar
  36. Fine D, Dicker L, Mosure D, Berman S (2008) Increasing chlamydia positivity in women screened in family planning clinics: do we know why? Sex Transm Dis 35:47–52CrossRefGoogle Scholar
  37. Fisman DN, Spain CV, Salmon ME, Goldberg M (2008) The Philadelphia high-school STD screening program: Key insights from dynamic transmission modeling. Sex Transm Dis 35:S61–S65CrossRefGoogle Scholar
  38. Garnett GP (2002) An introduction to mathematical models in sexually transmitted disease epidemiology. Sex Transm Infect 78:7–12CrossRefGoogle Scholar
  39. Garnett GP (2008) The transmission dynamics of sexually transmitted infections. In: Holmes KK, Sparling PF, Stamm WE, Piot P, Wasserheit JN, Corey L, Cohen MS, Watts DH (eds) Sexually Transmitted Diseases. Ch. 3. McGraw-Hill, New YorkGoogle Scholar
  40. Geisler WM, Wang C, Morrison SG, Black CM, Bandea CI, Hook EW, III (2008) The natural history of untreated Chlamydia trachomatis infection in the interval between screening and returning for treatment. Sex Transm Dis 35:119–123CrossRefGoogle Scholar
  41. Gift TL, Gaydos CA, Kent CK, Marrazzo JM, Rietmeijer CA, Schillinger JA, Dunne EF (2008) The program cost and cost-effectiveness of screening men for Chlamydia to prevent pelvic inflammatory disease in women. Sex Transm Dis 35:S66–S75CrossRefGoogle Scholar
  42. Golden MR, Hogben M, Handsfield HH, St Lawrence JS, Potterat JJ, Holmes KK (2003) Partner notification for HIV and STD in the United States: low coverage for gonorrhea, chlamydial infection, and HIV. Sex Transm Dis 30:490–496CrossRefGoogle Scholar
  43. Golden MR, Whittington WL, Handsfield HH, Hughes JP, Stamm WE, Hogben M, Clark A, Malinski C, Helmers JR, Thomas KK, Holmes KK (2005) Effect of expedited treatment of sex partners on recurrent or persistent gonorrhea or chlamydial infection. N Engl J Med 352:676–685CrossRefGoogle Scholar
  44. Gorgos L, Fine D, Marrazzo J (2008) Chlamydia positivity in American Indian/Alaska Native women screened in family planning clinics, 1997–2004. Sex Transm Dis 35:753–757CrossRefGoogle Scholar
  45. Haggerty CL, Schulz R, Ness RB (2003) Lower quality of life among women with chronic pelvic pain after pelvic inflammatory disease. Obstet Gynecol 102:934–939CrossRefGoogle Scholar
  46. Hiltunen-Back E, Haikala O, Kautiainen H, Ruutu P, Paavonen J, Reunala T (2003) Nationwide increase of Chlamydia trachomatis infection in Finland: highest rise among adolescent women and men. Sex Transm Dis 30:737–741CrossRefGoogle Scholar
  47. Hodge JG, Jr., Pulver A, Hogben M, Bhattacharya D, Brown EF (2008) Expedited partner therapy for sexually transmitted diseases: assessing the legal environment. Am J Public Health 98:238–243CrossRefGoogle Scholar
  48. Hogben M (2007) Partner notification for sexually transmitted diseases. Clin Infect Dis 44 Suppl 3:S160–S174MathSciNetCrossRefGoogle Scholar
  49. Hogben M, Brewer DD, Golden MR (2007) Partner notification and management intervention. In: Aral SO, Douglas JM, Lipshutz JA (eds) Behavioral Interventions for Prevention and Control of Sexually Transmitted Diseases. Ch. 7. Springer, New York, 170–189CrossRefGoogle Scholar
  50. Hull MG, Glazener CM, Kelly NJ, Conway DI, Foster PA, Hinton RA, Colson C, Lambert PA, Watt EM, Desai KM (1985) Population study of causes, treatment and outcome of infertility. Br Med J 291:1693–1697CrossRefGoogle Scholar
  51. Jacobson L, Westrom L (1969) Objectivized diagnosis of acute pelvic inflammatory disease. Diagnostic and prognostic value of routine laparoscopy. Am J Obstet Gynecol 105:1088–1098Google Scholar
  52. Joesoef MR, Mosure DJ (2006) Prevalence trends in chlamydial infections among young women entering the national job training program, 1998–2004. Sex Transm Dis 33:571–575CrossRefGoogle Scholar
  53. Johnson AM, Mercer CH, Erens B, Copas AJ, McManus S, Wellings K, Fenton KA, Korovessis C, Macdowall W, Nanchahal K, Purdon S, Field J (2001) Sexual behaviour in Britain: partnerships, practices, and HIV risk behaviours. Lancet 358:1835–1842CrossRefGoogle Scholar
  54. Kamwendo F, Forslin L, Bodin L, Danielsson D (1998) Programmes to reduce pelvic inflammatory disease––the Swedish experience. Lancet 351 Suppl 3:25–28CrossRefGoogle Scholar
  55. Kamwendo F, Forslin L, Bodin L, Danielsson D (2000) Epidemiology of ectopic pregnancy during a 28 year period and the role of pelvic inflammatory disease. Sex Transm Infect 76:28–32CrossRefGoogle Scholar
  56. Katz BP, Danos CS, Quinn TS, Caine V, Jones RB (1988) Efficiency and cost-effectiveness of field follow-up for patients with Chlamydia trachomatis infection in a sexually transmitted diseases clinic. Sex Transm Dis 15:11–16CrossRefGoogle Scholar
  57. Kelley SS, Borawski EA, Flocke SA, Keen KJ (2003) The role of sequential and concurrent sexual relationships in the risk of sexually transmitted diseases among adolescents. J Adolesc Health 32:296–305CrossRefGoogle Scholar
  58. Kissinger P, Mohammed H, Richardson-Alston G, Leichliter JS, Taylor SN, Martin DH, Farley TA (2005) Patient-delivered partner treatment for male urethritis: a randomized, controlled trial. Clin Infect Dis 41:623–629CrossRefGoogle Scholar
  59. Kissinger P, Schmidt N, Mohammed H, Leichliter JS, Gift TL, Meadors B, Sanders C, Farley TA (2006) Patient-delivered partner treatment for Trichomonas vaginalis infection: a randomized controlled trial. Sex Transm Dis 33:445–450CrossRefGoogle Scholar
  60. Klovstad H, Aavitsland P (2009) Chlamydia trachomatis infections in Norway, 1986 to 2006, surveillance data. Sex Transm Dis 36:17–21CrossRefGoogle Scholar
  61. Korenromp EL, Sudaryo MK, de Vlas SJ, Gray RH, Sewankambo NK, Serwadda D, Wawer MJ, Habbema JD (2002) What proportion of episodes of gonorrhoea and chlamydia becomes symptomatic? Int J STD AIDS 13:91–101CrossRefGoogle Scholar
  62. Kretzschmar M, van Duynhoven YT, Severijnen AJ (1996) Modeling prevention strategies for gonorrhea and chlamydia using stochastic network simulations. Am J Epidemiol 144: 306–317Google Scholar
  63. Kretzschmar M, Welte R, van den HA, Postma MJ (2001) Comparative model-based analysis of screening programs for Chlamydia trachomatis infections. Am J Epidemiol 153:90–101CrossRefGoogle Scholar
  64. La Montagne DS, Patrick LE, Fine DN, Marrazzo JM (2004) Re-evaluating selective screening criteria for chlamydial infection among women in the U S Pacific Northwest. Sex Transm Dis 31:283–289CrossRefGoogle Scholar
  65. Laumann EO (1994) The social organization of sexuality: Sexual practices in the United States. University of Chicago Press, Chicago, ILGoogle Scholar
  66. Laumann EO, Yoosik Y (1999) Racial/ethnic group differences in the prevalence of sexually transmitted diseases in the United States: A network explanation. Sex Transm Dis 26:250–261CrossRefGoogle Scholar
  67. Low, N(2004) Current status of chlamydia screening in Europe. Eurosurveillance 8(41), 1–4Google Scholar
  68. Low N (2007) Screening programmes for chlamydial infection: when will we ever learn? Brit Med J 334:725–728CrossRefGoogle Scholar
  69. Low N (2008) Caution: chlamydia surveillance data ahead. Sex Transm Infect 84:80–81CrossRefGoogle Scholar
  70. Low N, Egger M, Sterne JA, Harbord RM, Ibrahim F, Lindblom B, Herrmann B (2006) Incidence of severe reproductive tract complications associated with diagnosed genital chlamydial infection: the Uppsala Women's Cohort Study. Sex Transm Infect 82:212–218CrossRefGoogle Scholar
  71. Low N, McCarthy A, Macleod J, Salisbury C, Campbell R, Roberts TE, Horner P, Skidmore S, Sterne JA, Sanford E, Ibrahim F, Holloway A, Patel R, Barton PM, Robinson SM, Mills N, Graham A, Herring A, Caul EO, Davey SG, Hobbs FD, Ross JD, Egger M (2007) Epidemiological, social, diagnostic and economic evaluation of population screening for genital chlamydial infection. Health Technol Assess 11:iii-xii, 1Google Scholar
  72. Macaluso M, Wright-Schnapp TJ, Chandra A, Johnson R, Satterwhite CL, Pulver A, Berman SM, Wang RY, Farr SL, Pollack LA (2008) A public health focus on infertility prevention, detection, and management. Fertil SterilGoogle Scholar
  73. Makinen J, Rantala M, Vanha-Kamppa O (1998) A link between the epidemic of ectopic pregnancy and the "baby-boom" cohort. Am J Epidemiol 148:369–374Google Scholar
  74. Markos A (2008) Patient-delivered partner medication: the antagonism of clinical standards and good medical practice. Int J STD AIDS 19:283–284CrossRefGoogle Scholar
  75. Mathias SD, Kuppermann M, Liberman RF, Lipschutz RC, Steege JF (1996) Chronic pelvic pain: prevalence, health-related quality of life, and economic correlates. Obstet Gynecol 87:321–327CrossRefGoogle Scholar
  76. Mertz KJ, Ransom RL, St Louis ME, Groseclose SL, Hadgu A, Levine WC, Hayman C (2001) Prevalence of genital chlamydial infection in young women entering a national job training program, 1990–1997. Am J Public Health 91:1287–1290CrossRefGoogle Scholar
  77. Miller WC (2008) Epidemiology of chlamydial infection: are we losing ground? Sex Transm Infect 84:82–86CrossRefGoogle Scholar
  78. Miller WC, Ford CA, Morris M, Handcock MS, Schmitz JL, Hobbs MM, Cohen MS, Harris KM, Udry JR (2004) Prevalence of chlamydial and gonococcal infections among young adults in the United States. JAMA 291:2229–2236CrossRefGoogle Scholar
  79. Morre SA, van den Brule AJ, Rozendaal L, Boeke AJ, Voorhorst FJ, de Blok S, Meijer CJ (2002) The natural course of asymptomatic Chlamydia trachomatis infections: 45% clearance and no development of clinical PID after one-year follow-up. Int J STD AIDS 13:Suppl-8Google Scholar
  80. Morris M, Goodreau S, Moody J (2008) Sexual networks, concurrency, and STD/HIV. In: Holmes KK, Sparling PF, Stamm WE, Piot P, Wasserheit JN, Corey L, Cohen MS, Watts DH (eds) Sexually Transmitted Diseases. Ch. 7. McGraw-Hill, New YorkGoogle Scholar
  81. Mosher WD, Chandra A, Jones J (2005) Sexual behavior and selected health measures: Men and women 15–44 years of age, United States, 2002. Advance data from vital and health statistics; no 362. National Center for Health Statistics, Hyattsville, MDGoogle Scholar
  82. National Chlamydia Screening Programme (2008) NCSP: Five years. Annual report of the National Chlamydia Screening Programme in England 2007/08. Health Protection Agency, London.Google Scholar
  83. Nelson HD, Helfand M (2001) Screening for chlamydial infection. Am J Prev Med 20(suppl 3):95–107CrossRefGoogle Scholar
  84. Ness RB, Soper DE, Holley RL, Peipert J, Randall H, Sweet RL, Sondheimer SJ, Hendrix SL, Amortegui A, Trucco G, Songer T, Lave JR, Hillier SL, Bass DC, Kelsey SF (2002) Effectiveness of inpatient and outpatient treatment strategies for women with pelvic inflammatory disease: results from the Pelvic Inflammatory Disease Evaluation and Clinical Health (PEACH) Randomized Trial. Am J Obstet Gynecol 186:929–937CrossRefGoogle Scholar
  85. Op de Coul E , van den Broek IVF, Kretzschmar M (2007) Planned evaluation of an internet-based chlamydia screening implementation in the Netherlands. 17th ISSTDR 10th IUSTI World Congress, 393Google Scholar
  86. Paavonen J, Kousa M, Saikku P, Vartiainen E, Kanerva L, Laussus A (1980) Treatment of nongonococcal urethritis with trimethoprim-sulphadiazine and with placebo: A double-blind partner-controlled study. Br J Vener Dis 56:101–104Google Scholar
  87. Paavonen J, Westrom L, Eschenbach D (2008) Pelvic Inflammatory Disease. In: Holmes KK, Sparling PF, Stamm WE, Piot P, Wasserheit JN, Corey L, Cohen MS, Watts DH (eds) Sexually Transmitted Diseases. Ch. 56. McGraw-Hill, New York, 1017–1050Google Scholar
  88. Quinn TC, Gaydos C, Shepherd M, Bobo L, Hook EW, III, Viscidi R, Rompalo A (1996) Epidemiologic and microbiologic correlates of Chlamydia trachomatis infection in sexual partnerships. JAMA 276:1737–1742CrossRefGoogle Scholar
  89. Rahm VA, Belsheim J, Gleerup A, Gnarpe H, Rosen G (1986) Asymptomatic carriage of Chlamydia trachomatis: a study of 109 girls. Eur J STD AIDS 3:91–94Google Scholar
  90. Regan DG, Wilson DP, Hocking JS (2008) Coverage is the key for effective screening of Chlamydia trachomatis in Australia. J Infect Dis 198:349–358CrossRefGoogle Scholar
  91. Rekart ML, Brunham RC (2008) Epidemiology of chlamydial infection: are we losing ground? Sex Transm Infect 84:87–91CrossRefGoogle Scholar
  92. Roberts TE, Robinson S, Barton PM, Bryan S, McCarthy A, Macleod J, Egger M, Low N (2007) Cost effectiveness of home based population screening for Chlamydia trachomatis in the UK: economic evaluation of chlamydia screening studies (ClaSS) project. Brit Med J 335:291CrossRefGoogle Scholar
  93. Schachter J, Stephens RS (2008) Biology of Chlamydia trachomatis. In: Holmes KK, Sparling PF, Stamm WE, Piot P, Wasserheit JN, Corey L, Cohen MS, Watts DH (eds) Sexually Transmitted Diseases. Ch. 31. McGraw-Hill, New York,Google Scholar
  94. Schmidt L, Munster K, Helm P (1995) Infertility and the seeking of infertility treatment in a representative population. Br J Obstet Gynaecol 102:978–984CrossRefGoogle Scholar
  95. Scholes D, Stergachis A, Heidrich FE, Andrilla H, Holmes KK, Stamm WE (1996) Prevention of pelvic inflammatory disease by screening for cervical chlamydial infection. N Engl J Med 334:1362–1366CrossRefGoogle Scholar
  96. Simms I, Stephenson JM, Mallinson H, Peeling RW, Thomas K, Gokhale R, Rogers PA, Hay P, Oakeshott P, Hopwood J, Birley H, Hernon M (2006) Risk factors associated with pelvic inflammatory disease. Sex Transm Infect 82:452–457CrossRefGoogle Scholar
  97. Simms I, Warburton F, Westrom L (2003) Diagnosis of pelvic inflammatory disease: time for a rethink. Sex Transm Infect 79:491–494CrossRefGoogle Scholar
  98. Stamm WE (2008) Lymphogranuloma venereum. In: Holmes KK, Sparling PF, Stamm WE, Piot P, Wasserheit JN, Corey L, Cohen MS, Watts DH (eds) Sexually Transmitted Diseases. McGraw-Hill, New York.Google Scholar
  99. Stamm WE, Guinan ME, Johnson C (1984) Effect of treatment regimens for Neisseria gonorrhoeae on simultaneous infection with Chlamydia trachomatis. N Engl J Med 310:545–549CrossRefGoogle Scholar
  100. Stephen EH, Chandra A (2006) Declining estimates of infertility in the United States: 1982–2002. Fertil Steril 86:516–523CrossRefGoogle Scholar
  101. Sutton MY, Sternberg M, Zaidi A, St Louis ME, Markowitz LE (2005) Trends in pelvic inflammatory disease hospital discharges and ambulatory visits, United States, 1985–2001. Sex Transm Dis 32:778–784CrossRefGoogle Scholar
  102. Trelle S, Shang A, Nartey L, Cassell JA, Low N (2007) Improved effectiveness of partner notification for patients with sexually transmitted infections: systematic review. Brit Med J 334:354CrossRefGoogle Scholar
  103. Turner KM, Adams EJ, Gay N, Ghani AC, Mercer C, Edmunds WJ (2006a) Developing a realistic sexual network model of chlamydia transmission in Britain. Theor Biol Med Model 3:3CrossRefGoogle Scholar
  104. Turner KM, Adams EJ, LaMontagne DS, Emmett L, Baster K, Edmunds WJ (2006b) Modelling the effectiveness of chlamydia screening in England. Sex Transm Infect 82:496–502CrossRefGoogle Scholar
  105. van Bergen J, Gotz HM, Richardus JH, Hoebe CJ, Broer J, Coenen AJ, PILOT CT study group (2005) Prevalence of urogenital Chlamydia trachomatis increases significantly with level of urbanisation and suggests targeted screening approaches: results from the first national population based study in the Netherlands. Sex Transm InfectzbMATHGoogle Scholar
  106. Velicko I, Kuhlmann-Berenzon S, Blaxhult A (2007) Reasons for the sharp increase of genital chlamydia infections reported in the first months of 2007 in Sweden. Euro Surveill 12:E5–E6Google Scholar
  107. Wallace LA, Scoular A, Hart G, Reid M, Wilson P, Goldberg DJ (2008) What is the excess risk of infertility in women after genital chlamydia infection? A systematic review of the evidence. Sex Transm Infect 84:171–175CrossRefGoogle Scholar
  108. Wasserheit JN, Aral SO (1996) The dynamic topology of sexually transmitted disease epidemics: implications for prevention strategies. J Infect Dis 174 Suppl 2:S201–S213CrossRefGoogle Scholar
  109. Wellings K, Collumbien M, Slaymaker E, Singh S, Hodges Z, Patel D, Bajos N (2006) Sexual behaviour in context: a global perspective. Lancet 368:1706–1728CrossRefGoogle Scholar
  110. Welte R, Kretzschmar M, Leidl R, van den Hoek A, Jager JC, Postma MJ (2000) Cost-effectiveness of screening programs for Chlamydia trachomatis: a population-based dynamic approach. Sex Transm Dis 27:518–529CrossRefGoogle Scholar
  111. Westrom L (1975) Effect of acute pelvic inflammatory disease on fertility. Am J Obstet Gynecol 121:707–713Google Scholar
  112. Westrom L, Joesoef R, Reynolds G, Hadgu A, Thompson SE (1992) Pelvic inflammatory disease and fertility: A cohort study of 1,844 women with laparoscopically verified disease and 657 women with normal laparoscopy. Sex Transm Dis 19:185–192CrossRefGoogle Scholar
  113. White, C (2008) Government to press trusts to meet screening targets for chlamydia. Brit Med J 336:299CrossRefGoogle Scholar
  114. Wiesenfeld HC, Cates W, Jr. (2008) Sexually transmitted diseases and infertility. In: Holmes KK, Sparling PF, Stamm WE, Piot P, Wasserheit JN, Corey L, Cohen MS, Watts DH (eds) Sexually Transmitted Diseases. Ch. 99. McGraw-Hill, New York, 1493–1510Google Scholar
  115. Zane SB, Kieke BA, Jr., Kendrick JS, Bruce C (2002) Surveillance in a time of changing health care practices: estimating ectopic pregnancy incidence in the United States. Matern Child Health J 6:227–23CrossRefGoogle Scholar

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© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Centers for Disease Control and PreventionAtlantaUSA

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