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Soft-Tissue Sarcoma

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Handbook of Evidence-Based Radiation Oncology

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Abstract

∼10,400 cases/year and ∼3,700 deaths/year in the US Median age 40–60 years. Slight male predominance, more frequent among African-Americans. Genetics: NF-1, Retinoblastoma, Gardner’s syndrome, Li-Fraumeni syndrome. Environmental exposures: ionizing radiation, herbicides, thorotrast, chlorophenols, vinyl chloride, arsenic. Lower extremity (45%) > trunk (30%) > upper extremity (15%) > H&N (8%). Extremity = liposarcoma, MFH, synovial, fibrosarcoma, myxoid liposarcoma (upper medial thigh). Retroperitoneal = liposarcoma (fewer DM) > leiomyosarcoma (increased DM). H&N = MFH, usually high-grade (except myxoid MFH = intermediate grade). Frequency: MFH (20–30%), liposarcoma (10–20%), leiomyosarcoma (10–15%), fibrosarcoma (5–10%), synovial cell sarcoma (5–10%), rhabdomyosarcoma (5–10%), malignant peripheral nerve sheath tumor/malignant schwannoma (5%). Synovial sarcoma = usually high-grade, near (but not within) joints in tendon sheaths, bursae, and joint capsules. Grade based on cellularity, differentiation, pleomorphism, necrosis, #mitoses. Cytogenetics: See Appendix D.

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References

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Author information

Authors and Affiliations

  1. Radiation Oncology, Swedish Hospital, Seattle, WA, USA

    Brian Lee MD, PhD

  2. Radiation Oncology, University of California San Francisco, San Francisco, CA, USA

    Stuart Y. Tsuji MD, PhD & Alexander R. Gottschalk MD

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  1. Brian Lee MD, PhD
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  2. Stuart Y. Tsuji MD, PhD
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  3. Alexander R. Gottschalk MD
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Editor information

Editors and Affiliations

  1. Div. Radiation Oncology, Oregon Clinic, SW. Barnes Rd. 9205, Portland, 97225, Oregon, USA

    Eric K. Hansen

  2. Department of Radiation Oncology, University of California, San Francisco, Divisadero Street, Suite H-1031 1600, San Francisco, 94143, California, USA

    Mack Roach

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© 2010 Springer-Verlag New York

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Lee, B., Tsuji, S.Y., Gottschalk, A.R. (2010). Soft-Tissue Sarcoma. In: Hansen, E., Roach, M. (eds) Handbook of Evidence-Based Radiation Oncology. Springer, New York, NY. https://doi.org/10.1007/978-0-387-92988-0_40

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  • DOI: https://doi.org/10.1007/978-0-387-92988-0_40

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