Lymphocyte Apoptosis in Sepsis and Potential Anti-apoptotic Strategies

  • S. Weber
  • B. Baessler
  • S. Schroeder


Sepsis is a leading cause of death in many intensive care units [1]. The pathophysiology of sepsis is characterized by a dysregulation of the immune system in response to infection or secondary to trauma. Initial hyperinflammation often results in septic shock. Simultaneously, part of the immune system is deactivated leading to a emporary but often deadly immunosuppression. In attempting to arrive at a more detailed understanding of immunophysiological processes during sepsis over the last few years, apoptosis has been recognized as one of the key factors in the pathophysiology of sepsis [2]. As shown in several animal models, accelerated apoptosis seems to be induced in leukocytes and many immunocompetent cells during sepsis [3, 4]. Similar processes are involved in humans [5].


Systemic Inflammatory Response Syndrome Septic Patient Lymphocyte Apoptosis Polymicrobial Sepsis Apoptotic Protease Activate Factor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  • S. Weber
    • 1
  • B. Baessler
    • 1
  • S. Schroeder
    • 2
  1. 1.Department of Anesthesiology and Intensive CareUniversity of BonnBonnGermany
  2. 2.Department of Anesthesiology and Intensive CareWestküstenklinikum HeideHeideGermany

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