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Synthesis of Polychiral Natural Products from Carbohydrates

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Abstract

Stereoselective synthesis of polychiral natural products is the most challenging problem for a synthetic organic chemist. The stereoselective synthesis of macrolide antibiotics represents one such difficult problem. They consist of macrocyclic lactone rings with many hydroxylated and methylated chiral carbons. In addition to that the macrocyclic lactones (macrolides) are usually glycosylated with amino sugars.

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Notes

  1. 1.

    There are a couple of review articles dealing with this subject [1, 2].

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    Momcilo Miljković

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Miljković, M. (2010). Synthesis of Polychiral Natural Products from Carbohydrates. In: Carbohydrates. Springer, New York, NY. https://doi.org/10.1007/978-0-387-92265-2_13

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