Stem Cells

  • Louise Hecker
  • Victor J. Thannickal
  • Sem H. Phan
Part of the Molecular Pathology Library book series (MPLB, volume 2)


Stem cells are defined by their potential to self-renew and differentiate into more specialized cell types within a given tissue. Stem cells can be found in the embryo and in adult tissue and are termed embryonic stem cells and adult stem cells, respectively. Embryonic stem cells are responsible for the development of an entire organism, whereas adult stem cells provide a mechanism for maintenance of tissue homeostasis by replacing damaged cells throughout the life of the organism. Stem cell biology has provided a platform for addressing important scientific questions in the areas of development, repair/regeneration, and disease. Here, we discuss some basic concepts regarding stem cells, including definitions of commonly used terminology and the current status of the stem cell field. A glossary of terms defined in this chapter is given in Table 16.1 (Table 16.1).


Stem Cell Embryonic Stem Cell Cancer Stem Cell Adult Stem Cell Embryonic Stem Cell Research 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Spangrude GJ, Heimfeld S, Weissman IL. Purification and characterization of mouse hematopoietic stem cells. Science. 1988;241(4861):58–62.CrossRefPubMedGoogle Scholar
  2. 2.
    Baum CM, Weissman IL, Tsukamoto AS, Buckle AM, Peault B. Isolation of a candidate human hematopoietic stem-cell population. Proc Natl Acad Sci USA. 1992;89(7):2804–2808.CrossRefPubMedGoogle Scholar
  3. 3.
    Caplan AI, Bruder SP. Mesenchymal stem cells: building blocks for molecular medicine in the 21st century. Trends Mol Med. 2001;7(6):259–264.CrossRefPubMedGoogle Scholar
  4. 4.
    da Silva ML, Chagastelles PC, Nardi NB. Mesenchymal stem cells reside in virtually all post-natal organs and tissues. J Cell Sci. 2006;119(pt 11):2204–2213.CrossRefGoogle Scholar
  5. 5.
    Bruder SP, Jaiswal N, Ricalton NS, Mosca JD, Kraus KH, Kadiyala S. Mesenchymal stem cells in osteobiology and applied bone regeneration. Clin Orthop Relat Res. 1998;355(suppl):S247–S256.CrossRefPubMedGoogle Scholar
  6. 6.
    Osawa M, Hanada K, Hamada H, Nakauchi H. Long-term lymphohematopoietic reconstitution by a single CD34-low/negative hematopoietic stem cell. Science. 1996;273(5272):242–245.CrossRefPubMedGoogle Scholar
  7. 7.
    Ratajczak MZ, Kucia M, Reca R, Majka M, Janowska-Wieczorek A, Ratajczak J. Stem cell plasticity revisited: CXCR4-positive cells expressing mRNA for early muscle, liver and neural cells “hide out” in the bone marrow. Leukemia. 2004;18(1):29–40.CrossRefPubMedGoogle Scholar
  8. 8.
    Wagers AJ, Weissman IL. Plasticity of adult stem cells. Cell. 2004;116(5):639–648.CrossRefPubMedGoogle Scholar
  9. 9.
    varez-Dolado M, Pardal R, Garcia-Verdugo JM, et al. Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes. Nature. 2003;425(6961):968–973.CrossRefGoogle Scholar
  10. 10.
    Wagers AJ, Sherwood RI, Christensen JL, Weissman IL. Little evidence for developmental plasticity of adult hematopoietic stem cells. Science. 2002;297(5590):2256–2259.CrossRefPubMedGoogle Scholar
  11. 11.
    Hashimoto N, Jin H, Liu T, Chensue SW, Phan SH. Bone marrow-derived progenitor cells in pulmonary fibrosis. J Clin Invest. 2004;113(2):243–252.PubMedGoogle Scholar
  12. 12.
    Phillips RJ, Burdick MD, Hong K, et al. Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis. J Clin Invest. 2004;114(3):438–446.PubMedGoogle Scholar
  13. 13.
    Lama VN, Smith L, Badri L, et al. Evidence for tissue-resident mesenchymal stem cells in human adult lung from studies of transplanted allografts. J Clin Invest. 2007; 117(4):989–996.CrossRefPubMedGoogle Scholar
  14. 14.
    Bailey P, Holowacz T, Lassar AB. The origin of skeletal muscle stem cells in the embryo and the adult. Curr Opin Cell Biol. 2001;13(6):679–689.CrossRefPubMedGoogle Scholar
  15. 15.
    Raff M. Adult stem cell plasticity: fact or artifact? Annu Rev Cell Dev Biol. 2003;19:1–22.CrossRefPubMedGoogle Scholar
  16. 16.
    Tan BT, Park CY, Ailles LE, Weissman IL. The cancer stem cell hypothesis: a work in progress. Lab Invest. 2006;86(12):1203–1207.CrossRefPubMedGoogle Scholar
  17. 17.
    Lobo NA, Shimono Y, Qian D, Clarke MF. The biology of cancer stem cells. Annu Rev Cell Dev Biol. 2007;23:675–699.CrossRefPubMedGoogle Scholar
  18. 18.
    Bonnet D, Dick JE. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med. 1997;3(7):730–737.CrossRefPubMedGoogle Scholar
  19. 19.
    Moore BB, Kolodsick JE, Thannickal VJ, et al. CCR2-mediated recruitment of fibrocytes to the alveolar space after fibrotic injury. Am J Pathol. 2005;166(3):675–684.PubMedGoogle Scholar
  20. 20.
    Calado RT, Young NS. Telomere maintenance and human bone marrow failure. Blood. 2008;111(9):4446–4455.CrossRefPubMedGoogle Scholar
  21. 21.
    Yamanaka S. Induction of pluripotent stem cells from mouse fibroblasts by four transcription factors. Cell Prolif. 2008;41(suppl 1):51–56.PubMedGoogle Scholar
  22. 22.
    Yu J, Vodyanik MA, Smuga-Otto K, et al. Induced pluripotent stem cell lines derived from human somatic cells. Science. 2007;318(5858):1917–1920.CrossRefPubMedGoogle Scholar
  23. 23.
    Hanna J, Wernig M, Markoulaki S, et al. Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin. Science. 2007; 318(5858):1920–1923.CrossRefPubMedGoogle Scholar
  24. 24.
    Wernig M, Zhao JP, Pruszak J, et al. Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson’s disease. Proc Natl Acad Sci USA. 2008;105(15):5856–5861.CrossRefPubMedGoogle Scholar
  25. 25.
    Morigi M, Introna M, Imberti B, et al. Human bone marrow mesenchymal stem cells accelerate recovery of acute renal injury and prolong survival in mice. Stem Cells. 2008;26(8):2075–2082.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Louise Hecker
    • 1
  • Victor J. Thannickal
    • 2
  • Sem H. Phan
    • 3
  1. 1.Division of Pulmonary & Critical Care MedicineUniversity of Michigan Health System, Internal MedicineAnn ArborUSA
  2. 2.Division of Pulmonary & Critical Care MedicineUniversity of Michigan Health System, Internal MedicineAnn ArborUSA
  3. 3.Department of PathologyUniversity of MichiganAnn ArborUSA

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