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Molecular Signatures of Drug Resistance

  • Melissa A. TroesterEmail author
  • Jason I. Herschkowitz
  • Katherine A. Hoadley
Chapter

Abstract

Genomic methods are helping to overcome limitations of individual markers in predicting response to chemotherapy. Molecular signatures of cancer heterogeneity and drug resistance are being developed that use data from both observational and experimental settings. Genomic signatures that represent specific pathways and biological processes are being integrated from diverse data types, including cell line models, genetically engineered mouse models, and patient studies of drug resistance. This chapter highlights recent advances and future directions in genomics of drug resistance, with emphasis on integrating insights from different study settings.

Keywords

Microarrays Animal models Molecular signatures Stem cells Microenvironment Cancer heterogeneity 

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Melissa A. Troester
    • 1
    Email author
  • Jason I. Herschkowitz
    • 2
  • Katherine A. Hoadley
    • 3
  1. 1.Department of EpidemiologySchool of Public Health, University of North CarolinaChapel HillUSA
  2. 2.Department of Cell Biology –RosenBaylor College of MedicineHoustonUSA
  3. 3.Department of Genetics, Lineberger Comprehensive Cancer CenterUniversity of North Carolina at Chapel HillChapel HillUSA

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