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Disparities in Prostate Cancer

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Toward the Elimination of Cancer Disparities

Prostate cancer is the most commonly diagnosed non-skin cancer in the US and the second most common cause of cancer death among American men. In 2008 an estimated 186,320 men will be diagnosed with, and 28,660 will die of, prostate cancer in the US. Incidence rates increased dramatically in the 1990s attributable to prostate cancer screening but then declined after uncovering of prevalent cases. Mortality rates have trended downward in the past 15 years (Fig. 8.1).

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References

  • Akaza, H., Miyanaga, N., Takashima, N., Naito, S., Hirao, Y., Tsukamoto, T. et al. Comparisons of percent equal producers between prostate cancer patients and controls: case-controlled studies of isoflavones in Japanese, Korean, and American residents. Jap J Clin Oncol. 2004; 34(2):86–89.

    Article  Google Scholar 

  • Albano, J.D., Ward, E., Jemal, A., Anderson, R., Cokkinides, V.E, Murray, T. et al. Cancer mortality in the United States by education level and race. J Natl Cancer Inst. 2007; 99(18):1384–1394.

    Article  PubMed  Google Scholar 

  • American Cancer Society (2009). Chief medical officer Otis W. Brawley responds to prostate cancer studies. American Cancer Society. Retrieved March 25, 2008, from http://www.cancer.org/docroot/MED/content/MED_2_1×_Chief_Medical_Officer_Otis_W_Brawley_Responds_to_Prostate_Studies.asp.

  • Amling, C.L., Kane, C.J., Riffenburgh, R.H., Ward, J.F., Roberts, J.L., Lance, R.S. et al. Relationship between obesity and race in predicting adverse pathologic variables in patients undergoing radical prostatectomy. Urology. 2001; 58(5):723–728.

    Article  PubMed  CAS  Google Scholar 

  • Amling, C.L., Riffenburg, R.H., Sun, L., Moul, J.W., Lance, R.S., Kusada, L. et al. Pathologic variables and recurrence rates as related to obesity and race in men with prostate cancer undergoing radical prostatectomy. J Clin Oncol. 2004; 22(3):439–445.

    Article  PubMed  Google Scholar 

  • Andriole, G.L., Grubb, R.L., III, Buys, S.S., Chia, D., Church, T.R., Fouad, M.N., et al. Mortality results from a radomized prostate-cancer screening trial. New Engl J Med. 2009; 360(13). Retrieved March 26, 2009, from http://content.nejm.org/cgi/content/full/NEJMoa0810696.

  • Austin, J.P., Convery, K. Age-race interaction in prostatic adenocarcinoma treated with external beam irradiation. Am J Clin Oncol. 1993; 16(2):140–145.

    Article  PubMed  CAS  Google Scholar 

  • Austin, J.P., Aziz, H., Potters, L., Thelmo, W., Chen, P., Choi, K. et al. Diminished survival of young blacks with adenocarcinoma of the prostate. Am J Clin Oncol. 1990; 13(6):465–469.

    Article  PubMed  CAS  Google Scholar 

  • Bangsi, D., Zhou, J., Sun, Y., Patel, N.P., Darga, L.L., Heilbrun, L.K. et al. Impact of a genetic variant in CYP3A4 on risk and clinical presentation of prostate cancer among white and African-American men. Urol Oncol. 2006; 24(1):21–27.

    PubMed  CAS  Google Scholar 

  • Bach, P.B., Schrag, D., Brawley, O.W., Galaznik, A., Yakren, S., Begg, C.B. Survival of black and whites after a cancer diagnosis. J Am Med Assoc. 2002; 287(16):2106–2113.

    Article  Google Scholar 

  • Barry, M.J. Screening for prostate cancer – The controversy that refuses to die. New Engl J Med. 2009; 360(13). Retrieved March 26, 2009, from http://content.nejm.org/cgi/content/full/NEJMe0901166.

  • Bennett, C.L., Ferreira, M.R., Davis, T.C., Kaplan, J., Weinberger, M., Kuzel, T. et al. Relation between literacy, race, and stage of presentation among low-income patients with prostate cancer. J Clin Oncol. 1998; 16(9):3101–3104.

    PubMed  CAS  Google Scholar 

  • Bennett, C.L., Price, D.K., Kim, S., Liu, D., Jovanovic, B.D., Nathan, D. et al. Racial variation in CAG repeat lengths within the androgen receptor gene among prostate cancer patients of lower socioeconomic status. J Clin Oncol. 2002; 20(17):3599–3604.

    Article  PubMed  CAS  Google Scholar 

  • Ben-Shlomo, Y., Evans, S., Ibrahim, F., Patel, B., Anson, K., Chinegwundoh, F. et al. The risk of prostate cancer amongst black men in the United Kingdom: the PROCESS cohort study. Eur Urology. 2008; 53(1):99–105.

    Article  Google Scholar 

  • Brawley, O.W. Some perspective on black-white cancer statistics. CA Cancer J Clin. 2002; 52(6):322–325.

    Article  PubMed  Google Scholar 

  • Brawley, O.W. Population categorization and cancer statistics. Cancer Metastasis Rev. 2003; 22(1):11–19.

    Article  PubMed  Google Scholar 

  • Brawley, O.W., Ford, L.G., Thompson, I., Perlman, J.A., Kramer, B.S. 5-Alpha reductase inhibition and prostate cancer prevention. Cancer Epidemiol Biomarkers Prev. 1994; 3(2):177–182.

    PubMed  CAS  Google Scholar 

  • Brewster, D.H., Thomson, C.S., Hole, D.J., Black, R.J., Stroner, P.L., Gillis, C.R. Relation between socioeconomic status and tumor stage in patients with breast, colorectal, ovarian, and lung cancer: results from four national, population based studies. BMJ. 2001; 322(7290):830–831.

    Article  PubMed  CAS  Google Scholar 

  • Boyle, P. Screening for prostate cancer: have you had your cholesterol measured? BJU Int. 2003; 92(3):191–199.

    Article  PubMed  CAS  Google Scholar 

  • Brown, M.L., Potosky, A.L. The presidential effect: the public health response to media coverage about Ronald Reagan’s colon cancer episode. Pub Op Quarterly. 1990; 54(3):317–329.

    Article  CAS  Google Scholar 

  • Collin, S.M., Martin, R.M., Metcalfe, C., Gunnell, D., Albertsen, P.C., Neal, D. et al. Prostate-cancer mortality in the USA and UK in 1975–2004: an ecological study. Lancet Oncol. 2008; 9(5):445–452.

    Article  PubMed  Google Scholar 

  • Connell, P.P., Ignacio, L., Haraf, D., Awan, A.M., Halpern, H., Abdalla, I. et al. Equivalent racial outcome after conformal radiotherapy for prostate cancer: a single departmental experience. J Clin Oncol. 2001; 19(1):54–61.

    PubMed  CAS  Google Scholar 

  • Cooperberg, M.R., Lubeck, D.P., Meng, M.V., Mehta, S.S., Carroll, P.R. The changing face of low-risk prostate cancer: trends in clinical presentation and primary management. J Clin Oncol. 2006; 22(11):2141–2149.

    Article  Google Scholar 

  • de Koning, H.J., Auvinen, A., Berenguer-Sanchez, A., Calais da Silva, F, Ciatto, S., Denis, L. et al. Large-scale randomized prostate cancer screening trials: program performances in the European Randomized Screening for Prostate Cancer trial and the Prostate, Lung, Colorectal and Ovary Cancer trial. Int J Cancer. 2002; 97(2):237–244.

    Article  PubMed  CAS  Google Scholar 

  • Du, X.L., Fang, S., Coker, A.L., Sanderson, M., Aragaki, C., Cormier, J.N. Racial disparity and socioeconomic status in association with survival in older men with local/regional stage prostate carcinoma: findings from a large community-based cohort. Cancer. 2006; 106(6):1276–1285.

    Article  PubMed  Google Scholar 

  • Duffy, S.W., Nagtegaal, I.D., Wallis, M., Cafferty, F.H., Houssami, Warwick, J. et al. Correcting for lead time and length bias in estimating the effect of screen detection on cancer survival. Am J Epid. 2008; 168(1):98–104.

    Article  Google Scholar 

  • Edwards, B.K., Brown, M.L., Wingo, P.A., Howe, H.L., Ward, E., Ries, L.A. et al. Annual report to the nation on the status of cancer, 1975–2002, featuring population-based trends in cancer treatment. J Natl Cancer Inst. 2005; 97(19):1407–1427.

    Article  PubMed  Google Scholar 

  • Etzioni, R., Penson, D.F., Legler, J.M., di Tommaso, D., Boer, R., Gann, P.H. et al. Overdiagnosis due to prostate-specific antigen screening: lessons from U.S. prostate cancer incidence trends. J Natl Cancer Inst. 2002; 94(13):981–990.

    PubMed  Google Scholar 

  • Fiscella, K., Williams, D.R. Health disparities based on socioeconomic inequities: implications for urban health care. Acad Med. 2004; 79(12):1139–1147.

    Article  PubMed  Google Scholar 

  • Fowler, J.E., Bigler, S.A. Renfroe, D.L., Dabagia, M.D. Prostate specific antigen in black and white men after hormonal therapies for prostate cancer. J Urol. 1997; 158(1): 150–154.

    Article  PubMed  CAS  Google Scholar 

  • Fowler, J.E., Jr., Terrell, F.L., Renfroe, D.L. Co-morbidities and survival of men with localized prostate cancer treated with surgery or radiation therapy. J Urol. 1996; 156(5):1714–1718.

    Article  PubMed  Google Scholar 

  • Freedland, S.J., Jalkut, M., Dorey, F., Sutter, M.E., Aronson, W.J. Race is not an independent predictor of biochemical recurrence after radical prostatectomy in an equal access medical center. Urology. 2000; 56(1):87–91.

    Article  PubMed  CAS  Google Scholar 

  • Gilligan, T., Wang, P.S., Levin, R., Kantoff, P.W., Avorn, J. Racial differences in screening for prostate cancer in the elderly. Arch Int Med. 2004; 164:1858–1864.

    Article  Google Scholar 

  • Giovannucci, E. Vitamin D and cancer incidence in the Harvard cohorts. Ann Epid. 2009; 19(2):87–88.

    Google Scholar 

  • Giovannucci, E., Liu, Y., Platz, E.A., Stampfer, M.J., Willet, W.C. Risk factors for prostate cancer incidence and progression in the health professionals follow-up study. Int J Cancer. 2007; 121(7):1571–1578.

    Article  PubMed  CAS  Google Scholar 

  • Glover, F.E., Jr., Coffey, D.S., Douglas, L.L., Cadogan, M., Russell, H., Tulloch, T. et al. The epidemiology of prostate cancer in Jamaica. J Urol. 1998; 159(6):1984–1986.

    Article  PubMed  Google Scholar 

  • Godley, P.A., Schenck, A.P., Amamoo, M.A., Schoenbach, V.J., Peacock, S., Manning, M. et al. Racial differences in mortality among Medicare recipients after treatment for localized prostate cancer. J Natl Cancer Inst. 2003; 95(22):1702–1710.

    Google Scholar 

  • Gordon, N.H. Association of education and income with estrogen receptor status in primary breast cancer. Am J Epid. 1995; 142(8):796–803.

    CAS  Google Scholar 

  • Greenlee, R.T., Murray, T., Bolden, S., Wing, P.A., Cancer Statistics, 50: 7–33, 2000.

    Google Scholar 

  • Gross, C.P., Smith, B.D., Wolf, E., Andersen, M. Racial disparities in cancer therapy: did the gap narrow between 1992 and 2002? Cancer. 2008; 112(4):900–908.

    Article  PubMed  Google Scholar 

  • Haenszel, W. Studies of migrant populations. Am J Pub Health. 1985; 75(3):225–226.

    Article  CAS  Google Scholar 

  • Haenszel, W., Kurihara, M. Studies of Japanese migrants: mortality from cancer and other diseases among Japanese in the United States. J Natl Cancer Inst. 1968; 40(1):43–68.

    PubMed  CAS  Google Scholar 

  • Halpern, M.T., Ward, E.M., Pavluck, A.L., Schrag, N.M., Bian, J., Chen, A.Y. Association of insurance status and ethnicity with cancer stage at diagnosis for 12 cancer sites: a retrospective analysis. Lancet Oncol. 2008; 9(3):222–231.

    Article  PubMed  Google Scholar 

  • Harlan, L., Brawley, O., Pommerenke, F., Wali, P., Kramer, B. Geographic, age, and racial variation in the treatment of local/regional carcinoma of the prostate. J Clin Oncol. 1995; 13(1):93–100.

    PubMed  CAS  Google Scholar 

  • Harlan, L.C., Coates, R.J., Block, G., Greenberg, R.S., Ershow, A., Forman, M. et al. Estrogen receptor status and dietary intakes in breast cancer patients. Epid. 1993; 4(1):25–31.

    Article  CAS  Google Scholar 

  • Harlan, L.C., Potosky, A., Gilliland, F.D., Hoffman, R., Albertsen, P.C., Hamilton, A.S. et al. Factors associated with initial therapy for clinically localized prostate cancer: prostate cancer outcomes study. J Natl Cancer Inst. 2001; 93(24):1864–1871.

    Article  PubMed  CAS  Google Scholar 

  • Hart, K.B., Wood, D.P., Jr., Tekyi-Mensah, S., Porter, A.T., Pontes, J.E., Forman, J.D. The impact of race on biochemical disease-free survival in early-stage prostate cancer patients treated with surgery or radiation therapy. Int J Rad Oncol Biol Phys. 1999; 45(5):1235–1238.

    Article  CAS  Google Scholar 

  • Hernandez, W., Grenade, C., Santos, E.R., Bonilla, C., Ahaghotu, C., Kittles, R.A. IGF-1 and IGFBP-3 gene variants influence on serum levels and prostate cancer risk in African-Americans. Carcinogenesis. 2007; 28(10):2154–2159.

    Article  PubMed  CAS  Google Scholar 

  • Ingles, S.A., Ross, R.K., Yu, M.C., Irvine, R.A., La, P.G., Haile, R.W. et al. Association of prostate cancer risk with genetic polymorphisms in vitamin D receptor and androgen receptor. J Natl Cancer Inst. 1997; 89(2):166–170.

    Article  PubMed  CAS  Google Scholar 

  • Irvine, R.A., Yu, M.C., Ross, R.K., Coetzee, G.A. The CAG and GGC microsatellites of the androgen receptor gene are in linkage disequilibrium in men with prostate cancer. Cancer Res. 1995; 55(9):1937–1940.

    PubMed  CAS  Google Scholar 

  • Iselin, C.E., Box, J.W., Vollmer, R.T., Layfield, L.J., Robertson, J.E., Paulson, D.F. Surgical control of clinically localized prostate carcinoma equivalent in African-American and white males. Cancer. 1998; 83(11):2353–2360.

    Article  PubMed  CAS  Google Scholar 

  • Johnstone, P.A., Kane, C.J., Sun, L., Wu, H., Moul, J.W., McLeod, D.G. et al. Effect of race on biochemical disease-free outcome in patients with prostate cancer treated with definitive radiation therapy in an equal-access health care system: radiation oncology report of the Department of Defense Center for Prostate Disease Research. Radiology. 2002; 225(2):420–426.

    Article  PubMed  Google Scholar 

  • Kane, C.J., Lubeck, D.P., Knight, S.J., Spitalny, M., Downs, T.M., Grossfeld, G.D. et al. Impact of patient educational level on treatment for patients with prostate cancer: data from CaPSURE. Urology. 2003; 62(6):1035–1039.

    Article  PubMed  Google Scholar 

  • Kidd, L.C., Paltoo, D.N., Wang, S., Chen, W., Akereyeni, F., Issacs, W. et al. Sequence variation within the 5’ regulatory regions of the vitamin D binding protein and receptor genes and prostate cancer risk. Prostate. 2005;64(3):272–282.

    Article  PubMed  CAS  Google Scholar 

  • Kim, J.A., Kuban, D.A, el-Mahdi, A.M., Schellhammer, P.F. Carcinoma of the prostate: race as a prognostic indicator in definitive radiation therapy. Radiology. 1995; 194(2):545–549.

    PubMed  CAS  Google Scholar 

  • Kittles, R.A., Young, D., Weinrich, S., Hudson, J., Argyropoulos, G., Ukoli, F. et al. Extent of linkage disequilibrium between the androgen receptor gene CAG and GGC repeats in human populations: implications for prostate cancer risk. Hum Genet. 2001; 109(3):253–261.

    Article  PubMed  CAS  Google Scholar 

  • Klabunde, C.N., Potosky, A.L., Harlan, L.C., Kramer, B.S. Trends and black/white differences in treatment for nonmetastatic prostate cancer. Med Care. 1998; 36(9):1337–1348.

    Article  PubMed  CAS  Google Scholar 

  • Klein, E.A. Selenium and vitamin E cancer prevention trial. Ann NY Acad Sci. 2004; 1031:234–241.

    Article  PubMed  CAS  Google Scholar 

  • Klein, E.A., Silverman, R. Inflammation, infection, and prostate cancer. Curr Op Urol. 2008; 18(3):315–319.

    Article  Google Scholar 

  • Klein, E.A., Casey, G., Silverman, R. Genetic susceptibility and oxidative stress in prostate cancer: integrated model with implications for prevention. Urology 2006; 68(6):1145–1151.

    Article  PubMed  Google Scholar 

  • Kramer, B.S., Brown, M.L., Prorok, P.C., Potosky, A.L., Gohagen, J.K. Prostate cancer screening: what we know and what we need to know. Ann Int Med. 1993; 119(9):914–923.

    PubMed  CAS  Google Scholar 

  • Kripalani, S., Sharma, J., Justice, E., Justice, J., Spiker, C., Laufman, L.E. et al. Low-literacy interventions to promote discussion of prostate cancer: a randomized controlled trial. Am J Prev Med. 2007; 33(2):83–90.

    Article  PubMed  Google Scholar 

  • Kumar, R.J., Baha Barqawi, A.B., Crawford, E.D. Epidemiology of prostate cancer. Business Briefing: US Oncology Review 2004: 42–45.

    Google Scholar 

  • Liu, L., Cozen, W., Bernstein, L., Ross, R.K., Deapen, D. Changing relationship between socioeconomic status and prostate cancer incidence. J Natl Cancer Inst. 2001; 93(9):705–709.

    Article  PubMed  CAS  Google Scholar 

  • Litman, H.J., Bhasin, S., Link, C.L., Araujo, A.B., McKinlay, J.B. Serum androgen levels in black, Hispanic, and white men. J Clin Endocrin Metab. 2006; 91(11):4326–4334.

    Article  CAS  Google Scholar 

  • Lu-Yao, G., Albertsen, P.C., Stanford, J.L., Stukel, T.A., Walker-Corkery, E.S., Barry, M.J. Natural experiment examining impact of aggressive screening and treatment on prostate cancer mortality in two fixed cohorts from Seattle area and Connecticut. BMJ. 2002; 325(7367):740.

    Article  PubMed  Google Scholar 

  • Lu-Yao, G., Moore, D.F., Oleynick, J., DiPaola, R.S., Yao, S.L. Use of hormonal therapy in men with metastatic prostate cancer. J Urol. 2006; 176(2):526–531.

    Article  PubMed  Google Scholar 

  • Mariotto, A.B., Etzioni, R., Krapcho, M., Feuer, E.J. Reconstructing PSA testing patterns between black and white men in the US from Medicare claims and the National Health Interview Survey. Cancer. 2007; 109(9):1877–1886.

    Article  PubMed  Google Scholar 

  • McLeod, D.G., Schellhammer, P.F., Vogelzang, N.J., Soloway, M.S., Sharifi, R., Black, N.L. et al. Exploratory analysis on the effect of race on clinical outcome in patients with advanced prostate cancer receiving bicalutamide or flutamide, each in combination with LHRH analogues. The Casodex Combination Study Group. Prostate. 1999; 40(4):218–224.

    Article  PubMed  CAS  Google Scholar 

  • Miller, D.C., Gruber, S.B., Hollenbeck, B.K., Montie, J.E., Wei, J.T. Incidence of initial local therapy among men with lower-risk prostate cancer in the United States. J Natl Cancer Inst. 2006; 98(16):1134–1141.

    Article  PubMed  Google Scholar 

  • Morris, C.R., Snipes, K.P., Schlag, R., Wright, W.E. Sociodemographic factors associated with prostatectomy utilization and concordance with the physician data query for prostate cancer (United States). Cancer Causes Control. 1999; 10(6):503–511.

    Article  PubMed  CAS  Google Scholar 

  • Moul, J., Douglas, T., McCarthy, W., McLeod, D. Black race is an adverse prognostic factor for prostate cancer recurrence following radical prostatectomy in an equal access health care setting. J Urol. 1996; 155(5):1667–1672.

    Article  PubMed  CAS  Google Scholar 

  • Nielsen, M.E., Han, M., Mangold, L., Humphreys, E., Walsh, P.C., Partin, A.W. et al. Black race does not independently predict adverse outcome following radical retropubic prostatectomy at a tertiary referral center. J Urol. 2006; 176(2): 515–519.

    Article  PubMed  Google Scholar 

  • Oakley-Girvan, I., Kolonel, L.N., Gallagher, R.P., Wu, A.H., Felberg, A., Whittemore, A.S. Stage at diagnosis and survival in a multiethnic cohort of prostate cancer patients. Am J Pub Health. 2003; 93(10):1753–1759.

    Article  Google Scholar 

  • Odedina, F.T., Ogunbiyi, J.O., Ukoli, F.A. Roots of prostate cancer in African-American men. J Natl Med Assn. 2006; 98(4):539–543.

    Google Scholar 

  • Pan, C.C., Lee, J.S., Chan, J.L., Sandler, H.M., Underwood, W., McLaughlin, P.W. The association between presentation PSA and race in two sequential time periods in prostate cancer patients seen at a university hospital and its community affiliates. Int J Rad Oncology, Biology, Physics. 2003; 57(5):1292–1296.

    Article  Google Scholar 

  • Panz, V.R., Joffe, B.I., Spitz, I., Lindenberg, T., Farkas, A., Haffejee, M. Tandem CAG repeats of the androgen receptor gene and prostate cancer risk in black and white men. Endocrine. 2001; 15(2):213–216.

    Article  PubMed  CAS  Google Scholar 

  • Park, J., Chen, L., Ratnashinge, L., Sellers, T.A., Tanner, J.P., Lee, J.H. et al. Deletion polymorphism of UDP-glucuronosyltransferase 2B17 and risk of prostate cancer in African American and Caucasian men. Cancer, Epidemiology, Biomarkers, and Prevention. 2006; 15(8):1473–1478.

    Article  CAS  Google Scholar 

  • Parkin, D.M., Whelan, S.L., Ferlay, J., Raymond, L., Young, J., eds. Cancer Incidence in Five Continents, Vol 7. Lyon (France), IARC Scientific Publication No. 143, IARC Press; 1997.

    Google Scholar 

  • Peters, N., Armstrong, K. Racial differences in prostate cancer treatment outcomes. Cancer Nurs. 2005; 28(2):108–116.

    Article  PubMed  Google Scholar 

  • Phillips, A.A., Jacobson, J.S., Magai, C., Consedine, N., Horowicz-Mehler, N.C., Neugut, A.I. Cancer incidence and mortality in the Caribbean. Cancer Invest. 2007; 25(6):476–483.

    Article  PubMed  Google Scholar 

  • Platz, E.A., Rimm, E.B., Willett, W.C., Kantoff, P.W., Giovannucci, E. Racial variation in prostate cancer incidence and in hormonal system markers among male health professionals. J Natl Cancer Inst. 2000; 92(24):2009–2017.

    Article  PubMed  CAS  Google Scholar 

  • Polednak, A.P. Stage at diagnosis of prostate cancer in Connecticut by poverty and race. Ethnicity and Disease. 1997; 7(3):215–220.

    PubMed  CAS  Google Scholar 

  • Potosky, A.L., Feuer, E.J., Levin, D.L. Impact of screening on incidence and mortality in the United States. Epidem Rev. 2001; 23(1):181–186.

    CAS  Google Scholar 

  • Powell, I.J., Dey, J., Dudley, A., Pontes, J.E., Cher, M.L., Sakr, W. et al. Disease-free survival difference between African Americans and whites after radical prostatectomy for local prostate cancer: a multivariable analysis. Urol. 2002; 59: 907–912.

    Article  PubMed  Google Scholar 

  • Powell, I.J., Land, S.J., Dey, J., Heilbrun, L.K., Hughes, M.R., Sakr, W. et al. The impact of CAG repeats in exon 1 of the androgen receptor on disease progression after prostatectomy. Cancer. 2005; 103(3):528–537.

    Article  PubMed  CAS  Google Scholar 

  • Reed, A., Ankerst, D.P., Pollack, B.H., Thompson, I.M., Parekh, D.J. Current age and race adjusted prostate specific antigen threshold values delay diagnosis of high grade prostate cancer. J Urol. 2007; 178(5):1929–1932.

    Article  PubMed  Google Scholar 

  • Ries L.A.G., Melbert, D., Krapcho, M., Stinchcomb, D.G., Howlader, N., Horner, M.J., Mariotto, A., Miller, B.A., Feuer, E.J., Altekruse, S.F., Lewis, D.R., Clegg, L., Eisner, M.P., Reichman, M., Edwards, B.K., (Eds). SEER Cancer Statistics Review, 1975–2005, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2005, based on November 2007 SEER data submission, posted to the SEER web site, 2008.

  • Ries, L.A.G., Harkins, D., Krapcho, M., Mariotto, A., Miller, B.A., Feuer, E.J. et al. SEER cancer statistic review, 1975–2003. Bethesda: National Cancer Institute, 2006 http://www.seercancer.gov/csr/1975–2002. Accessed August 4, 2008.

  • Roach, M., III. Krall, J., Keller, J.W., Perez, C.A., Sause, W.T., Doggett, R.L. et al. The prognostic significance of race and survival from prostate cancer based on patients irradiated on Radiation Therapy Oncology Group protocols (1976–1985). Int J Rad Oncol Biol Phys. 1992; 24(3):441–449.

    Article  Google Scholar 

  • Robbins, A.S., Whittemore, A.S., Thom, D.H. Differences in socioeconomic status and survival among white and black men with prostate cancer. Am J Epidem. 2000; 151(4):409–416.

    CAS  Google Scholar 

  • Robbins, A.S., Yin, D., Parikh-Patel, A. Differences in prognostic factors and survival among white men and black men with prostate cancer, California, 1995–2004. Am J Epidem. 2007; 166(1):71–78.

    Article  Google Scholar 

  • Rodriguez, C., McCullough, M.L., Mondul, A.M., Jacobs, E.J., Chao, A., Patel, A.V. et al. Meat consumption among blacks and white men and risk of prostate cancer in the Cancer Prevention Study II Nutrition Cohort. Cancer Epidem Biomarkers Prev. 2006; 15(2):211–216.

    Article  Google Scholar 

  • Roetzheim, R.G., Pal, N., Tennant, C., Voti, L., Ayanian, J.Z., Schwabe, A. et al. Effects of health insurance and race on early detection of cancer. J Natl Cancer Inst. 1999; 91(16):1409–1415.

    Article  PubMed  CAS  Google Scholar 

  • Rohrmann, S., Nelson, W.G., Rifai, N., Brown, T.R., Dobs, A., Kanarek, N. et al. Serum estrogen, but not testosterone, levels differ between black and white men in a nationally representative sample of Americans. J Clin Endo Met. 2007; 92(7):2519–2525.

    Article  CAS  Google Scholar 

  • Ross, R.K. The role of molecular genetics in chemoprevention studies of prostate cancer. IARC Scientific Publications. 2001; 154:207–213.

    PubMed  CAS  Google Scholar 

  • Ross, L.E., Berkowitz, Z., Ekwueme, D.U. Use of the prostate-specific antigen test among U.S. men: findings from the 2005 National Health Interview Survey. Cancer, Epidemiology, Biomarkers, and Prevention. 2008; 17(3):636–644.

    Article  Google Scholar 

  • Ross, R.K., Pike, M.C., Coetzee, G.A., Reichardt, J.K., Yu, M.C., Feigelson, H. et al. Androgen metabolism and prostate cancer: establishing a model of genetic susceptibility. Cancer Res. 1998; 58(20):4497–4504.

    PubMed  CAS  Google Scholar 

  • Sakr, W.A., Billis, A., Ekman, P., Wilt, T., Bostwick, D.G. Epidemiology of high-grade prostatic intraepithelial neoplasia. Scand J Urol Nephr. Supp, 2000; 205:11–18.

    Article  Google Scholar 

  • Sakr, W.A., Grignon, D.J., Crissman, J.D., Heilbrun, L.K., Cassin, B.J., Pontes, J.J. et al. High grade prostatic intraepithelial neoplasia (HGPIN) and prostatic adenocarcinoma between the ages of 20–69: an autopsy study of 249 cases. In Vivo. 1994; 8(3):439–443.

    PubMed  CAS  Google Scholar 

  • Salam, M.T., Ursin, G., Skinner, E.C., Dessissa, T., Reichardt, J.K. Associations between polymorphisms in the steroid 5-alpha reductase type II (SRD5A2) gene and benign prostatic hyperplasia and prostate cancer. Urol Oncol. 2005; 23(4):246–253.

    PubMed  CAS  Google Scholar 

  • Sanchez-Chapado, M., Olmedilla, G., Cabeza, M., Donat, E., Ruiz, A. Prevalence of prostate cancer and prostatic intraepithelial neoplasia in Caucasian Mediterranean males: an autopsy study. Prostate. 2003; 54(3):238–247.

    Article  PubMed  Google Scholar 

  • Sarter, O., Zheng, Q., Eastham, J.A. Androgen receptor gene CAG repeat length varies in a race-specific fashion in men without prostate cancer. Urol. 1999; 53(2):378–380.

    Article  Google Scholar 

  • Satia-Abouta, J., Patterson, R.E., Schiller, R.N., Kristal, A.R. Energy from fat is associated with obesity in U.S. men: results from the Prostate Cancer Prevention Trial. Prev Med. 2002; 34(5):493–501.

    Article  PubMed  Google Scholar 

  • Schro¨der, F.H., Hugosson, J., Roobol, M.J., Tammela, T.L.J., Ciatto, S., Nelen, V., et al. Screening and prostate-cancer mortality in a randomized European study. New Engl J Med. 2009; 360(13). Retrieved March 26, 2009, from http://content.nejm.org/cgi/content/full/NEJMoa0810084.

  • Schumacher, F.R., Feigelson, H.S., Cox, D.G., Haiman, C.A., Albanes, D., Buring, J. et al. A common 8q24 variant in prostate and breast cancer from a large nested case-control study. Cancer Res. 2007; 67(7):2951–2956.

    Article  PubMed  CAS  Google Scholar 

  • Schwartz, K.L., Crossley-May, H., Vigneau, F.D., Brown, K., Banerjee, M. Race, socioeconomic status and stage at diagnosis for five common malignancies. Cancer Causes Control. 2003; 14(8):761–766.

    Article  PubMed  Google Scholar 

  • Shavers, V.L., Brown, M.L. Racial and ethnic disparities in the receipt of cancer treatment. J Natl Cancer Inst. 94(5):334–357.

    Google Scholar 

  • Shavers, V.L., Brown, M.L., Potosky, A.L., Klabunde, C.N., Davis, W.W., Moul, J.W. et al. Race/ethnicity and the receipt of watchful waiting for the initial management of prostate cancer. J General Int Med. 2004; 19(2): 146–155.

    Article  Google Scholar 

  • Shekarriz, B., Tiguert, R., Upadhyay, J., Gheiler, E., Powell, I.J., Pontes, J.E. et al. Impact of location and multifocality of positive surgical margins on disease-free survival following radical prostatectomy: a comparison between African-American and white men. Urol. 2000; 55(6):899–903.

    Article  PubMed  CAS  Google Scholar 

  • Shibata, A., Ma, J., Whittemore, A.S. Prostate cancer incidence and mortality in the United States and the United Kingdom. J Natl Cancer Inst. 1998; 90(16):1230–1231.

    Article  PubMed  CAS  Google Scholar 

  • Shibata, A., Whittemore, A.S. Re: Prostate cancer incidence and mortality in the United States and the United Kingdom. (Letter). J Natl Cancer Inst. 2001; 93(14):1109–1110.

    Article  PubMed  CAS  Google Scholar 

  • Soos, G., Tsakiris, I., Szanto, J., Turzo, C., Haas, P.G., Dezso, B. The prevalence of prostate carcinoma and its precursor in Hungary: an autopsy study. Eur Urol. 2005; 48(5):739–744.

    Article  PubMed  Google Scholar 

  • Spangler, E., Zeigler-Johnson, C.M., Coomes, M., Malkowicz, S.B., Wein, A., Rebbeck, T.R. Association of obesity with tumor characteristics and treatment failure of prostate cancer in African-American and European American men. J Urol. 2007; 178(5):1939–1944.

    Article  PubMed  CAS  Google Scholar 

  • Stangelberger, A., Waldert, M., Djavan, B. Prostate cancer in elderly men. Rev Urol. 2008; 10(2):111–119.

    PubMed  Google Scholar 

  • Steenland, K., Rodriguez, C., Mondul, A., Calle, E.E., Thun, M. Prostate cancer incidence and survival in relation to education (United States). Cancer Causes Control. 2004; 15(9):939–945.

    Article  PubMed  Google Scholar 

  • Tannock, I.F., de Wit, R., Horti, J., Pluzanska, A., Chi, K.N. et al. Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer, NEJM. 2004; 351(15):1502–1512.

    Article  PubMed  CAS  Google Scholar 

  • Tarman, G.J., Kane, C.J., Moul, J.W., Thrasher, J.B., Foley, J.P., Wilhite, D. et al. Impact of socioeconomic status and race on clinical parameters of patients undergoing radical prostatectomy in an equal access health care system. Urol. 2000; 56(6):1016–1020.

    Article  PubMed  CAS  Google Scholar 

  • Taylor, K.L., Davis, J.L., III., Turner, R.O., Johnson, L., Schwartz, M.D., Kerner, J.F. et al. Educating African American men about the prostate cancer screening dilemma: A randomized intervention. Cancer Epidem Biomarkers Prev. 2006; 15:2179–2188.

    Article  Google Scholar 

  • Telesca, D., Etzioni, R., Gulati, R. Estimating lead time and overdiagnosis associated with PSA screening from prostate cancer incidence trends. Biometrics. 2007; 64(1):10–19.

    Article  PubMed  Google Scholar 

  • Thompson, I.M., Ankerst, D.P., Chi, C., Goodman, P.J., Tangen, C.M., Lucia, M.S. et al. Assessing prostate cancer risk: results form the Prostate Cancer Prevention Trial. J Natl Cancer Inst. 2006; 98(8):529–534.

    Article  PubMed  Google Scholar 

  • Thompson, I.M., Basler, J.A., Leach, R., Troyer, D., Klein, E., Brawley, O. Challenges and opportunities to the design and implementation of chemoprevention trials for prostate cancer. Urol Oncol. 2003; 21(1):73–78.

    PubMed  Google Scholar 

  • Thompson, I.M., Goodman, P.J., Tangen, C.M., Lucia, M.S., Miller, G.J., Ford, L.G. et al. The influence of finasteride on the development of prostate cancer, NEJM. 2003; 349(3):215–224.

    Article  PubMed  CAS  Google Scholar 

  • U.S. Preventive Services Task Force. Screening for prostate cancer: U.S. Preventive Task Force Recommendation Statement. Ann Int Med. 2008; 149 (3):185–191.

    Google Scholar 

  • Vogt, T.M., Ziegler, R.G., Patterson, B.H., Graubard, B.I. Racial differences in serum selenium concentration: analysis of US population data from the Third National Health and Nutrition Examination Survey. Am J Epidem. 2007; 166(3):280–288.

    Article  Google Scholar 

  • Williams, D.R. Race, health, and health care. St. Louis Univ Law J. 2003; 48(1):13–35.

    PubMed  Google Scholar 

  • Williams, D.R. The health of men: Structured inequalities and opportunities. Am J Pub Health. 2003; 93(5):724–731.

    Article  Google Scholar 

  • Williams, D.R. The health of U.S. racial and ethnic populations. Journal of Gerontology. Series B. Psych Sci Soc Scie. 2005; 60(2):53–62.

    Google Scholar 

  • Williams, D.R., Collins, C. U.S. socioeconomic and racial differences in health. Annual Review of Sociology. 1995; 21:349–386.

    Article  Google Scholar 

  • Williams, D.R., Jackson, P.B. Social sources of racial disparities in health. Health Affairs (Millwood). 2005; 24(2):325–334.

    Article  Google Scholar 

  • Wolf, M.S., Knight, S.J., Lyons, E.A., Durazo-Arvizu, R., Pickard, S.A., Arseven, A. et al. Literacy, race, and PSA level among low-income men newly diagnosed with prostate cancer. Urol. 2006; 68(1):89–93.

    Article  PubMed  Google Scholar 

  • Wood, H.M., Reuther, A.M., Gilligan, T.D., Kupelian, P.A., Modlin, C.S., Jr., Klein, E.A. Rates of biochemical remission remain higher in black men compared to white men after radical prostatectomy despite similar trends in prostate specific antigen induced stage migration. Journal of Urology. 2007; 178(4 Pt 1):1271–1276.

    Article  PubMed  Google Scholar 

  • Yao, S.L., Lu-Yao, G. Understanding and appreciating overdiagnosis in the PSA era. J Nat Cancer Inst. 2002; 94(13):958–960.

    PubMed  Google Scholar 

  • Young, C.D., Lewis, P., Weinberg, V., Lee, T.T., Coleman, C.W., Roach, M, III. The impact of race on freedom from prostate-specific antigen failure in prostate cancer patients treated with definite radiation therapy. Semin Urol Oncol. 2000; 18(2):121–126.

    PubMed  CAS  Google Scholar 

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Brawley, O.W., Wallington, S.F. (2009). Disparities in Prostate Cancer. In: Koh, H. (eds) Toward the Elimination of Cancer Disparities. Springer, New York, NY. https://doi.org/10.1007/978-0-387-89443-0_8

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