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Functions of the Persistent Na+ Current in Cortical Neurons Revealed by Dynamic Clamp

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Dynamic-Clamp

Part of the book series: Springer Series in Computational Neuroscience ((NEUROSCI,volume 1))

Abstract

Many cortical neurons and other vertebrate nerve cells are equipped with a persistent Na+ current, I NaP, which operates at membrane potentials near the action potential threshold. This current may strongly influence integration and transduction of synaptic input into spike patterns. However, due to the lack of pharmacological tools for selective blockade or enhancement of I NaP, its impact on spike generation has remained enigmatic. By using dynamic clamp to cancel or add I NaP during intracellular recordings in rat hippocampal pyramidal cells, we were able to circumvent this long-standing problem. Combined with computational modeling our dynamic-clamp experiments disclosed how I NaP strongly affects the transduction of excitatory current into action potentials in these neurons. First, we used computational model simulations to predict functional roles of I NaP, including unexpected effects on spike timing and current–frequency relations. We then used the dynamic-clamp technique to experimentally test and confirm our model predictions.

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Acknowledgments

Our work was supported by the Norwegian Research Council (NFR) through FUGE, NevroNor, and the Norwegian Centre of Excellence programs, and by HFSP for Research Grant RGP0049 to L.J.G. and J.F.S.

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  1. Department of Physiology at Institute of Basal Medicine, and Centre of Molecular Biology and Neuroscience, University of Oslo, PB 1103 Blindern, N-0317 Oslo, Norway

    J.F. Storm

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  1. J.F. Storm
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  2. K. Vervaeke
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  3. H. Hu
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Correspondence to J.F. Storm .

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    Storm, J., Vervaeke, K., Hu, H., Graham, L. (2009). Functions of the Persistent Na+ Current in Cortical Neurons Revealed by Dynamic Clamp. In: Bal, T., Destexhe, A. (eds) Dynamic-Clamp. Springer Series in Computational Neuroscience, vol 1. Springer, New York, NY. https://doi.org/10.1007/978-0-387-89279-5_8

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