Aradi I, Santhakumar V, Soltesz I (2004) Impact of heterogeneous perisomatic IPSC populations on pyramidal cell firing rates. J Neurophysiol 91:2849–2858.
Arsiero M, Luescher HR, Giugliano M (2005) The mean-field dynamic-clamp: linking single- neuron properties to network activity in in vitro preparations. In: Society for Neuroscience Meeting. 823.1.
Bedard C, Destexhe A (2008) A modified cable formalism for modeling neuronal membranes at high frequencies. Biophys J 94:1133–1143.
Ben-Ari Y (2002) Excitatory actions of gaba during development: the nature of the nurture. Nat Rev Neurosci 3:728–739.
Berecki G, Zegers JG, Verkerk AO, Bhuiyan ZA, de Jonge B, Veldkamp MW, Wilders R, van Ginneken ACG (2005) HERG channel (dys)function revealed by dynamic action potential clamp technique. Biophys J 88:566–578.
Bettencourt JC, Lillis KP, Stupin LR, White JA (2008) Effects of imperfect dynamic clamp: Computational and experimental results. J Neurosci Methods 169:282–289.
Brette R, Piwkowska Z, Monier C, Rudolph-Lilith M, Fournier J, Levy M, Fregnac Y, Bal T, Destexhe A (2008) High-resolution intracellular recordings using a real-time computational model of the electrode. Neuron 59:379–391.
Brizzi L, Meunier C, Zytnicki D, Donnet M, Hansel D, LaMotte D'Incamps B, Van Vreeswikj C (2004) How shunting inhibition affects the discharge of lumbar motoneurones. A dynamic clamp study in anaesthetised cats. J Physiol 558:671–683.
Chance FS, Abbott LF, Reyes AD (2002) Gain modulation from background synaptic input. Neuron 35:773–782.
Cohen I, Navarro V, Clemenceau S, Baulac M, Miles R (2002) On the origin of interictal activity in human temporal lobe epilepsy in vitro. Science 298:1418–1421.
de Polavieja GG, Harsch A, Kleppe I, Robinson HP, Juusola M (2005) Stimulus history reliably shapes action potential waveforms of cortical neurons. J Neurosci 25:5657–5665.
Derjean D, Bertrand S, Le Masson G, Landry M, Morisset V, Nagy F (2003) Dynamic balance of metabotropic inputs causes dorsal horn neurons to switch functional states. Nat Neurosci 6:274–281.
Desai NS, Walcott EC (2006) Synaptic bombardment modulates muscarinic effects in forelimb motor cortex. J Neurosci 26:2215–2226.
Destexhe A, Pare D (1999) Impact of network activity on the integrative properties of neocortical pyramidal neurons in vivo. J Neurophysiol 81:1531–1547.
Destexhe A, Rudolph M, Fellous JM, Sejnowski TJ (2001) Fluctuating synaptic conductances recreate in vivo-like activity in neocortical neurons. Neuroscience 107:13–24.
Dorval AD, Christini DJ, White JA (2001) Real-Time linux dynamic clamp: a fast and flexible way to construct virtual ion channels in living cells. Ann Biomed Eng 29:897–907.
Dorval AD, Jr., White JA (2005) Channel noise is essential for perithreshold oscillations in entorhinal stellate neurons. J Neurosci 25:10025–10028.
Dorval AD, White JA (2006) Synaptic input statistics tune the variability and reproducibility of neuronal responses. Chaos 16:026105.
Elson RC, Selverston Al, Abarbanel HD, Rabinovich MI (2002) Inhibitory synchronization of bursting in biological neurons: dependence on synaptic time constant. J Neurophysiol 88:1166–1176.
Fellous JM, Rudolph M, Destexhe A, Sejnowski TJ (2003) Synaptic background noise controls the input/output characteristics of single cells in an in vitro model of in vivo activity. Neuroscience 122:811–829.
Fellous JM, Sejnowski TJ (2003) Regulation of persistent activity by background inhibition in an in vitro model of a cortical microcircuit. Cereb Cortex 13:1232–1241.
Fernandez FR, White JA (2008) Artificial synaptic conductances reduce subthreshold oscillations and periodic firing in stellate cells of the entorhinal cortex. J Neurosci 28:3790–3803.
Foldy C, Aradi I, Howard A, Soltesz I (2004) Diversity beyond variance: modulation of firing rates and network coherence by GABAergic subpopulations. Eur J Neurosci 19:119–130.
Gauck V, Jaeger D (2000) The control of rate and timing of spikes in the deep cerebellar nuclei by inhibition. J Neurosci 20:3006–3016.
Gauck V, Jaeger D (2003) The contribution of NMDA and AMPA conductances to the control of spiking in neurons of the deep cerebellar nuclei. J Neurosci 23:8109–8118.
Goaillard JM, Marder E (2006) Dynamic clamp analyses of cardiac, endocrine, and neural function. Physiology (Bethesda) 21:197–207.
Goldman MS, Golowasch J, Marder E, Abbott LF (2001) Global structure, robustness, and modulation of neuronal models. J Neurosci 21:5229–5238.
Gulledge AT, Stuart GJ (2003) Excitatory actions of GABA in the cortex. Neuron 37:299–309.
Haider B, Duque A, Hasenstaub AR, Yu Y, McCormick DA (2007) Enhancement of visual responsiveness by spontaneous local network activity in vivo. J Neurophysiol 97:4186–4202.
Hanson JE, Jaeger D (2002) Short-term plasticity shapes the response to simulated normal and parkinsonian input patterns in the globus pallidus. J Neurosci 22:5164–5172.
Harsch A, Robinson HP (2000) Postsynaptic variability of firing in rat cortical neurons: the roles of input synchronization and synaptic NMDA receptor conductance. J Neurosci 20:6181–6192.
Hasenstaub A, Shu Y, Haider B, Kraushaar U, Duque A, McCormick DA (2005) Inhibitory postsynaptic potentials carry synchronized frequency information in active cortical networks. Neuron 47:423–435.
Hines ML, Carnevale NT (1997) The NEURON simulation environment. Neural Comput 9:1179–1209.
Hughes SW, Cope DW, Crunelli V (1998) Dynamic clamp study of Ih modulation of burst firing and delta oscillations in thalamocortical neurons in vitro. Neuroscience 87:541–550.
Hughes SW, Cope DW, Toth TI, Williams SR, Crunelli V (1999) All thalamocortical neurones possess a T-type Ca2+ 'window' current that enables the expression of bistability-mediated activities. J Physiol 517:805–815.
Hughes SW, Lorincz M, Cope DW, Crunelli V (2008) NeuReal: An interactive simulation system for implementing artificial dendrites and large hybrid networks. J Neurosci Methods 169:290–301.
Jaeger D, Bower JM (1999) Synaptic control of spiking in cerebellar Purkinje cells: dynamic current clamp based on model conductances. J Neurosci 19:6090–6101.
Kreiner L, Jaeger D (2004) Synaptic shunting by a baseline of synaptic conductances modulates responses to inhibitory input volleys in cerebellar Purkinje cells. Cerebellum 3:112–125.
Le Franc Y, Foutry B, Nagy F, Le Masson G (2001) Nociceptive signal transfer through the dorsal horn network: hybrid and dynamic clamp approaches using a real-time implementation of the Neuron simulation environment. In: Society for Neuroscience Meeting. 927.18
Le Masson G, Renaud-Le Masson S, Sharp AA, Marder E, Abbott LF (1992) Real-time interaction between a model neuron and the crustacean stomatogastric nervous system In: Society for Neuroscience Meeting. 18, 1055.
Le Masson G, Le Masson S, Moulins M (1995) From conductances to neural network properties: analysis of simple circuits using the hybrid network method. Prog Biophys Mol Biol 64:201–220.
Le Masson S, Laflaquiere A, Bal T, Le Masson G (1999) Analog circuits for modeling biological neural networks: design and applications. IEEE Trans Biomed Eng 46:638–645.
Le Masson G, Renaud-Le Masson S, Debay D, Bal T (2002) Feedback inhibition controls spike transfer in hybrid thalamic circuits. Nature 417:854–858.
Lien CC, Jonas P (2003) Kv3 potassium conductance is necessary and kinetically optimized for high-frequency action potential generation in hippocampal interneurons. J Neurosci 23:2058–2068.
Manor Y, Nadim F (2001) Synaptic depression mediates bistability in neuronal networks with recurrent inhibitory connectivity. J Neurosci 21:9460–9470.
Manuel M, Meunier C, Donnet M, Zytnicki D (2005) How much afterhyperpolarization conductance is recruited by an action potential? A dynamic-clamp study in cat lumbar motoneurons. J Neurosci 25:8917–8923.
Manuel M, Meunier C, Donnet M, Zytnicki D (2006) The afterhyperpolarization conductance exerts the same control over the gain and variability of motoneurone firing in anaesthetized cats. J Physiol 576:873–886.
Manuel M, Meunier C, Donnet M, Zytnicki D (2007) Resonant or not, two amplification modes of proprioceptive inputs by persistent inward currents in spinal motoneurons. J Neurosci 27:12977–12988.
McCarren M, Alger BE (1985) Use-dependent depression of IPSPs in rat hippocampal pyramidal cells in vitro. J Neurophysiol 53:557–571.
McCormick DA, Shu Y, Hasenstaub A, Sanchez-Vives M, Badoual M, Bal T (2003) Persistent cortical activity: mechanisms of generation and effects on neuronal excitability. Cereb Cortex 13:1219–1231.
Milescu LS, Yamanishi T, Ptak K, Mogri MZ, Smith JC (2008) Real-time kinetic modeling of voltage-gated ion channels using dynamic clamp. Biophys J 95:66–87.
Mitchell SJ, Silver RA (2003) Shunting inhibition modulates neuronal gain during synaptic excitation. Neuron 38:433–445.
Morita K, Kalra R, Aihara K, Robinson HP (2008) Recurrent synaptic input and the timing of gamma-frequency-modulated firing of pyramidal cells during neocortical “UP” states. J Neurosci 28:1871–1881.
Netoff TI, Banks MI, Dorval AD, Acker CD, Haas JS, Kopell N, White JA (2005) Synchronization in hybrid neuronal networks of the hippocampal formation. J Neurophysiol 93:1197–1208.
Nowotny T, Zhigulin VP, Selverston AI, Abarbanel HD, Rabinovich MI (2003) Enhancement of synchronization in a hybrid neural circuit by spike-timing dependent plasticity. J Neurosci 23:9776–9785.
Oprisan SA, Prinz AA, Canavier CC (2004) Phase resetting and phase locking in hybrid circuits of one model and one biological neuron. Biophys J 87:2283–2298.
Piwkowska Z, Pospischil M, Brette R, Sliwa J, Rudolph-Lilith M, Bal T, Destexhe A (2008) Characterizing synaptic conductance fluctuations in cortical neurons and their influence on spike generation. J Neurosci Methods 169:302–322.
Pospischil M, Piwkowska Z, Rudolph M, Bal T, Destexhe A (2007) Calculating event-triggered average synaptic conductances from the membrane potential. J Neurophysiol 97:2544–2552.
Prescott SA, De Koninck Y (2003) Gain control of firing rate by shunting inhibition: roles of synaptic noise and dendritic saturation. Proc Natl Acad Sci USA 100:2076–2081.
Prescott SA, Ratté S, De Koninck Y, Sejnowski TJ (2006) Nonlinear interaction between shunting and adaptation controls a switch between integration and coincidence detection in pyramidal neurons. J Neurosci 26: 9084–9097.
Prinz AA, Thirumalai V, Marder E (2003) The functional consequences of changes in the strength and duration of synaptic inputs to oscillatory neurons. J Neurosci 23:943–954.
Prinz AA, Abbott LF, Marder E (2004) The dynamic clamp comes of age. Trends Neurosci 27:218–224.
Prinz AA (2004) Neural networks: models and neurons show hybrid vigor in real time. Curr Biol 14:R661–662.
Reyes AD, Rubel EW, Spain WJ (1996) In vitro analysis of optimal stimuli for phase-locking and time-delayed modulation of firing in avian nucleus laminaris neurons. J Neurosci 16:993–1007.
Reyes AD (2003) Synchrony-dependent propagation of firing rate in iteratively constructed networks in vitro. Nat Neurosci 6:593–599.
Robinson HP, Kawai N (1993) Injection of digitally synthesized synaptic conductance transients to measure the integrative properties of neurons. J Neurosci Methods 49:157–165.
Robinson HP (2008) A scriptable DSP-based system for dynamic conductance injection. J Neurosci Methods 169:271–281.
Rudolph M, Piwkowska Z, Badoual M, Bal T, Destexhe A (2004) A method to estimate synaptic conductances from membrane potential fluctuations. J Neurophysiol 91:2884–2896.
Schreiber S, Fellous JM, Tiesinga P, Sejnowski TJ (2004) Influence of ionic conductances on spike timing reliability of cortical neurons for suprathreshold rhythmic inputs. J Neurophysiol 91:194–205.
Scott S (1979) Stimulation Simulations of Young Yet Cultured Beating Hearts. In: Buffalo, NY: State University of New York.
Sharp AA, O'Neil MB, Abbott LF, Marder E (1993) Dynamic clamp: computer-generated conductances in real neurons. J Neurophysiol 69:992–995.
Sharp AA, Skinner FK, Marder E (1996) Mechanisms of oscillation in dynamic clamp constructed two-cell half-center circuits. J Neurophysiol 76:867–883.
Shu Y, Hasenstaub A, Badoual M, Bal T, McCormick DA (2003) Barrages of synaptic activity control the gain and sensitivity of cortical neurons. J Neurosci 23:10388–10401.
Shu Y, Hasenstaub A, Duque A, Yu Y, McCormick DA (2006) Modulation of intracortical synaptic potentials by presynaptic somatic membrane potential. Nature 441:761–765.
Siegelbaum SA, Koester J (2000) Ion channels. In: Principles of neural science, 4th Edition (Kandel ER, Schwartz JH, Jessell TM, eds). New York, NY: McGraw-Hill.
Sohal VS, Huguenard JR (2005) Inhibitory coupling specifically generates emergent gamma oscillations in diverse cell types. Proc Natl Acad Sci USA 102:18638–18643.
Sorensen M, DeWeerth S, Cymbalyuk G, Calabrese RL (2004) Using a hybrid neural system to reveal regulation of neuronal network activity by an intrinsic current. J Neurosci 24:5427–5438.
Stein V, Nicoll RA (2003) GABA generates excitement. Neuron 37:375–378.
Suter KJ, Jaeger D (2004) Reliable control of spike rate and spike timing by rapid input transients in cerebellar stellate cells. Neuroscience 124:305–317.
Swensen AM, Marder E (2001) Modulators with convergent cellular actions elicit distinct circuit outputs. J Neurosci 21:4050–4058.
Tan RC, Joyner RW (1990) Electrotonic influences on action potentials from isolated ventricular cells. Circ Res 67:1071–1081.
Tateno T, Robinson HP (2006) Rate coding and spike-time variability in cortical neurons with two types of threshold dynamics. J Neurophysiol 95:2650–2663.
Thompson SM, Gahwiler BH (1989a) Activity-dependent disinhibition. I. Repetitive stimulation reduces IPSP driving force and conductance in the hippocampus in vitro. J Neurophysiol 61:501–511.
Thompson SM, Gahwiler BH (1989b) Activity-dependent disinhibition. II. Effects of extracellular potassium, furosemide, and membrane potential on ECl- in hippocampal CA3 neurons. J Neurophysiol 61:512–523.
Tyzio R, Cossart R, Khalilov I, Minlebaev M, Hubner CA, Represa A, Ben-Ari Y, Khazipov R (2006) Maternal oxytocin triggers a transient inhibitory switch in GABA signaling in the fetal brain during delivery. Science 314:1788–1792.
Ulrich D, Huguenard JR (1996) Gamma-aminobutyric acid type B receptor-dependent burst-firing in thalamic neurons: a dynamic clamp study. Proc Natl Acad Sci USA 93:13245–13249.
Ulrich D, Huguenard JR (1997) GABA(A)-receptor-mediated rebound burst firing and burst shunting in thalamus. J Neurophysiol 78:1748–1751.
Verheijck EE, Wilders R, Joyner RW, Golod DA, Kumar R, Jongsma HJ, Bouman LN, van Ginneken AC (1998) Pacemaker synchronization of electrically coupled rabbit sinoatrial node cells. J Gen Physiol 111:95–112.
Vervaeke K, Hu H, Graham LJ, Storm JF (2006) Contrasting effects of the persistent Na+ current on neuronal excitability and spike timing. Neuron 49:257–270.
Vida I, Bartos M, Jonas P (2006) Shunting inhibition improves robustness of gamma oscillations in hippocampal interneuron networks by homogenizing firing rates. Neuron 49:107–117.
Wilders R, Verheijck EE, Kumar R, Goolsby WN, van Ginneken AC, Joyner RW, Jongsma HJ (1996) Model clamp and its application to synchronization of rabbit sinoatrial node cells. Am J Physiol 271:H2168–2182.
Williams SR and Stuart GJ (2003) Voltage- and site-dependent control of the somatic impact of dendritic IPSPs. J Neurosci 23, 7358–7367.
Williams SR (2004) Spatial compartmentalization and functional impact of conductance in pyramidal neurons. Nat Neurosci 7:961–967.
Williams SR (2005) Encoding and decoding of dendritic excitation during active states in pyramidal neurons. J Neurosci 25:5894–5902.
Williams SR and Mitchell SJ (2008) Direct measurement of somatic voltage clamp errors in central neurons. Nature Neurosci 11:790–798.
Wolfart J, Debay D, Le Masson G, Destexhe A, Bal T (2005) Synaptic background activity controls spike transfer from thalamus to cortex. Nat Neurosci 8:1760–1767.
Yarom Y (1991) Rhythmogenesis in a hybrid system – interconnecting an olivary neuron to an analog network of coupled oscillators. Neuroscience 44:263–275.
Zosimovskii VA, Balaban PM, Zakharov IS, Sokolov EN (1980) [Study of monosynaptic excitatory connections using a biomathematical model of neuronal interaction] Neirofiziologiia 12(4):413–420. Russian.
Zosimovskii VA (1980) [Use of EC-1020 computers for experimental studies of synaptic interaction of mollusk neurons] Zh Vyssh Nerv Deiat Im I P Pavlova. 30(6):1306–1311. Russian.
Zsiros V, Hestrin S (2005) Background synaptic conductance and precision of EPSP-spike coupling at pyramidal cells. J Neurophysiol 93:3248–3256.