Abstract
Bioactive gel-glasses composed of CaO-P2O5-SiO2 are used to repair bone defects and have potential applications in tissue engineering. A bioactive material elicits a specific biological response at the interface of the material which results in the formation of a mechanically strong bond between the tissues and the material [1]. There are two classes of bioactivity, which depend upon the rate and type of tissue response to the implant. Class A bioactive materials exhibit rapid bonding to bone, bone growth along the implant interface, termed osteoconduction, enhanced rates of bone proliferation, termed osteoproduction, and bonding to soft connective tissues. Class B bioactive materials exhibit slow rates of bone bonding and bone growth and no adherence to soft connective tissues. Bioactive geglasses have Class A bioactivity. An important advantage of bioactive gelglasses is that their rate of resorption and dissolution can be controlled during bone repair or tissue engineering by varying either composition or texture.
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Hench, L.L., Fielder, E. (2004). Biological Gel-Glasses. In: Aegerter, M.A., Mennig, M. (eds) Sol-Gel Technologies for Glass Producers and Users. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-88953-5_21
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DOI: https://doi.org/10.1007/978-0-387-88953-5_21
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4419-5455-8
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