Tumor-Infiltrating Dendritic Cells: The Pathologist’s Perspective

  • Dmitry W. GutkinEmail author


In order to perform immunosurveillance and initiate antitumor immune response, dendritic cells must be physically present in malignant tissues. This chapter summarizes data on the density and functional status of tumor-infiltrating dendritic cells in different types of human malignant neoplasms, generated by immunohistochemistry methods. The results show that density and maturation of tumor-associated dendritic cells vary in specific types of tumors and correlate with histologic grade and clinical stage of the disease. In majority of cases there is positive correlation between intratumoral dendritic cell density and favorable disease prognosis; however, certain exceptions are present. Possible mechanisms of tumor-related alterations of dendritic cell homing, survival, and maturation at the tumor site are discussed.


Dendritic Cell Squamous Cell Carcinoma Oral Squamous Cell Carcinoma Laryngeal Squamous Cell Carcinoma Plasmacytoid Dendritic Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Program Leader, Pathology and Lab Medicine, VAMC PittsburghUniversity Drive CPittsburghUSA

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