Dendritic Cell Tumors

  • Lourdes R. YlaganEmail author


Neoplasms of histiocytes and dendritic cells are rare, and their phenotypic and biological definition is incomplete. This chapter deals with the morphology of dendritic cell tumors as seen by pathologists and cytopathologists. It is divided into three sections: the follicular dendritic cell tumor, the interdigitating dendritic reticulum cell tumor and Langerhans cell histiocytosis. Currently used immunohistochemical markers of differentiation are presented and discussed to help in the differential diagnosis of these entities.


Dendritic Cell Follicular Dendritic Cell Eosinophilic Granuloma Germinal Center Formation Dendritic Cell Sarcoma 
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  1. Allen, C. E. and McClain, K. L. 2007. Langerhans cell histiocytosis: a review of past, current and future therapies. Drugs Today (Barc) 43:627–643.CrossRefGoogle Scholar
  2. Beham-Schmid, C., Beham, A., Jakse, R., Aubock, L. and Hofler, G. 1998. Extranodal follicular dendritic cell tumour of the nasopharynx. Virchows Arch 432:293–298.PubMedCrossRefGoogle Scholar
  3. Chan, J. K., Fletcher, C. D., Nayler, S. J. and Cooper, K. 1997. Follicular dendritic cell sarcoma. Clinicopathologic analysis of 17 cases suggesting a malignant potential higher than currently recognized. Cancer 79:294–313.PubMedCrossRefGoogle Scholar
  4. Chan, J. K., Tsang, W. Y. and Ng, C. S. 1994a. Follicular dendritic cell tumor and vascular neoplasm complicating hyaline-vascular Castleman's disease. Am J Surg Pathol 18:517–525.PubMedCrossRefGoogle Scholar
  5. Chan, J. K., Tsang, W. Y., Ng, C. S., Tang, S. K., Yu, H. C. and Lee, A. W. 1994b. Follicular dendritic cell tumors of the oral cavity. Am J Surg Pathol 18:148–157.PubMedCrossRefGoogle Scholar
  6. Fonseca, R., Yamakawa, M., Nakamura, S., van Heerde, P., Miettinen, M., Shek, T. W., Myhre Jensen, O., Rousselet, M. C. and Tefferi, A. 1998. Follicular dendritic cell sarcoma and interdigitating reticulum cell sarcoma: a review. Am J Hematol 59:161–167.PubMedCrossRefGoogle Scholar
  7. Galati, L. T., Barnes, E. L. and Myers, E. N. 1999. Dendritic cell sarcoma of the thyroid. Head Neck 21:273–275.PubMedCrossRefGoogle Scholar
  8. Hollowood, K., Stamp, G., Zouvani, I. and Fletcher, C. D. 1995. Extranodal follicular dendritic cell sarcoma of the gastrointestinal tract. Morphologic, immunohistochemical and ultrastructural analysis of two cases. Am J Clin Pathol 103:90–97.PubMedGoogle Scholar
  9. James Vardiman (Eds) IARC Press, Lyon 2001:275–301.Google Scholar
  10. Kairouz, S., Hashash, J., Kabbara, W., McHayleh, W. and Tabbara, I. A. 2007. Dendritic cell neoplasms: an overview. Am J Hematol 82:924–928.PubMedCrossRefGoogle Scholar
  11. Monda, L., Warnke, R. and Rosai, J. 1986. A primary lymph node malignancy with features suggestive of dendritic reticulum cell differentiation. A report of 4 cases. Am J Pathol 122:562–572.Google Scholar
  12. Nayler, S. J., Verhaart, M. J. and Cooper, K. 1996. Follicular dendritic cell tumour of the tonsil. Histopathology 28:89–92.PubMedCrossRefGoogle Scholar
  13. Perez-Ordonez, B. and Rosai, J. 1995. Follicular dendritic cell tumor: Report of 13 additional cases of a distinctive entity. Annual meeting extracts. Lab Invest. 72:118A.Google Scholar
  14. Perez-Ordonez, B. and Rosai, J. 1998. Follicular dendritic cell tumor: review of the entity. Semin Diagn Pathol 15:144–154.PubMedGoogle Scholar
  15. Pileri, S. A., Grogan, T. M., Harris, N. L., Banks, P., Campo, E., Chan, J. K., Favera, R. D., Delsol, G., De Wolf-Peeters, C., Falini, B., Gascoyne, R. D., Gaulard, P., Gatter, K. C., Isaacson, P. G., Jaffe, E. S., Kluin, P., Knowles, D. M., Mason, D. Y., Mori, S., Muller-Hermelink, H. K., Piris, M. A., Ralfkiaer, E., Stein, H., Su, I. J., Warnke, R. A. and Weiss, L. M. 2002. Tumours of histiocytes and accessory dendritic cells: an immunohistochemical approach to classification from the International Lymphoma Study Group based on 61 cases. Histopathology 41:1–29.PubMedCrossRefGoogle Scholar
  16. Satter, E. K. and High, W. A. 2008. Langerhans cell histiocytosis: a review of the current recommendations of the Histiocyte Society. Pediatr Dermatol 25:291–295.PubMedCrossRefGoogle Scholar
  17. Shek, T. W., Ho, F. C., Ng, I. O., Chan, A. C., Ma, L. and Srivastava, G. 1996. Follicular dendritic cell tumor of the liver. Evidence for an Epstein-Barr virus-related clonal proliferation of follicular dendritic cells. Am J Surg Pathol 20:313–324.PubMedCrossRefGoogle Scholar
  18. WHO. 2001. Tumours of Haematopoietic and Lymphoid Tissues. World Health Organization Classification of Tumours. Elaine Jaffe, Nancy Lee Harris, Herald Stein,Google Scholar
  19. Ylagan, L. R., Bartlett, N. L. and Kraus, M. 2003. Interdigitating dendritic reticulum cell tumor of lymph nodes: case report with differential diagnostic considerations. Diagn Cytopathol 28:278–281.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Washington University Medical SchoolSt. LouisUSA

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