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Cellular and Molecular Mechanisms of Pulmonary Vascular Smooth Muscle Cell Proliferation

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Textbook of Pulmonary Vascular Disease

Abstract

Pulmonary arterial hypertension is the end result of a complex series of events termed “vascular remodeling,” which includes proliferation of resident smooth muscle cells in the walls of small muscular pulmonary arteries. This process leads to increased thickness of the smooth muscle component of the vessel wall, which then contributes to reduced lumen diameter and increased contractility. Since smooth muscle cell proliferation contributes significantly to the process of vascular remodeling, it is important to appreciate the main factors driving this process in the hypertensive lung. This chapter will review the basic mechanisms of vascular smooth muscle cell proliferation, focusing on work in pulmonary vascular cells.

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Authors and Affiliations

  1. Department of Medicine, Addenbrooke’s Hospital, Hills Road, 157, Cambridge, CB4 1LL, UK

    Tamara Tajsic

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  1. Tamara Tajsic
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  2. Nicholas W. Morrell
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Correspondence to Tamara Tajsic .

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Editors and Affiliations

  1. Departments of Medicine, COMRB Rm. 3131 (MC 719), University of Illinois at Chicago, 909 South Wolcott Avenue, Chicago, 60612, Illinois, USA

    Jason X. -J. Yuan

  2. 310 Admin.Office Building (MC 672), University of Illinois at Chicago, 1737 W. Polk Street, Suite 310, Chicago, 60612, Illinois, USA

    Joe G.N. Garcia

  3. Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, 92093-0623, California, USA

    John B. West

  4. Dept. Pulmonary & Critical Care Medicine, Massachusetts General Hospital, 55 Fruit Street, Boston, 02114, Massachusetts, USA

    Charles A. Hales

  5. Department of Medicine, University of Chicago Medical Center, 5841 S. Maryland Ave., Chicago, 60637, Illinois, USA

    Stuart Rich

  6. Department of Medicine, University of Chicago School of Medicine, 5841 S. Maryland Ave., Chicago, 60637, Illinois, USA

    Stephen L. Archer

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Tajsic, T., Morrell, N.W. (2011). Cellular and Molecular Mechanisms of Pulmonary Vascular Smooth Muscle Cell Proliferation. In: Yuan, JJ., Garcia, J., West, J., Hales, C., Rich, S., Archer, S. (eds) Textbook of Pulmonary Vascular Disease. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-87429-6_20

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