The Influence Of Flow Redistribution On Working Rat Muscle Oxygenation

  • Louis Hoofd
  • Hans Degens
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 645)


We applied a theoretical model of muscle tissue O2 transport to investigate the effects of flow redistribution on rat soleus muscle oxygenation. The situation chosen was the anaerobic threshold where redistribution of flow is expected to have the largest impact. In the basic situation all capillaries received an equal proportion of the total flow through the tissue, resulting in 4.7% anoxic tissue and a mean tissue PO2 = 3.62 kPa. Both a redistribution of flow where 1) capillaries in blocks of tissue receiving 50% of the basic flow alternated with tissue blocks with capillaries receiving 150% of the basic flow (6.8% anoxic tissue; mean tissue PO2 = 3.32 kPa) and 2) matching flow to O2 consumption (3.3% anoxic tissue; mean tissue PO2 = 3.60 kPa) had little effect. When overall flow was decreased by 20%, the anoxic tissue increased to 7.6% and the mean tissue PO2 decreased to 3.22 kPa. The conclusion from these model calculations is, that flow redistribution has little impact on skeletal muscle oxygenation, which is in line with earlier findings for rat heart.


Tissue Oxygenation Capillary Number Anaerobic Threshold Muscle Oxygenation Supply Area 
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© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Louis Hoofd
    • 1
  • Hans Degens
    • 2
  1. 1.143 Department of PhysiologyRadboud University Nijmegen Medical Centre
  2. 2.Institute for Biophysical and Clinical Research into Human MovementManchester Metropolitan University Alsager CampusAlsagerUK

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