Abstract
The dynamic changes in cerebral metabolic rate of oxygen (CMRO2) and oxygen supply during brain functions have not been well-characterized. To examine this issue, experiments with electrophysiology, oxygen microelectrode and laser-Doppler flowmetry were performed in the anesthetized rat somatosensory cortex. During neural activation, brain tissue partial pressure of oxygen (Po2) and local cerebral blood flow (CBF) were similarly increased. To separate the Po2 changes originating from the increase in CMRO2 and the increase in oxygen supply, the same experiments were repeated under a vasodilator-induced hypotension condition in which evoked CBF change was minimal. In this condition, evoked Po2 monotonically decreased, indicating an increase in CMRO2. Then, CMRO2 was determined at resting as well as activation periods using a dynamic oxygen exchange model. Our results indicated that the changes in CMRO2 were linearly related with the summation of evoked field potentials and further showed that the oxygen supply in the normal condition was about 2.5 times larger than the demand. However, this oxygen oversupply was not explainable by the change in CBF alone, but at least partly by the increase in oxygenation levels at pre-capillary arterioles (e.g., 82% to 90% O2 saturation level) when local neural activity was evoked.
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References
T. Nagaoka, F. Zhao, P. Wang, N. Harel, R. P. Kennan, S. Ogawa, and S. G. Kim, Increases in oxygen consumption without cerebral blood volume change during visual stimulation under hypotension condition, J Cereb Blood Flow Metab 26, 1043-1051 (2006).
M. Fukuda, P. Wang, C. H. Moon, M. Tanifuji, and S. G. Kim, Spatial specificity of the enhanced dip inherently induced by prolonged oxygen consumption in cat visual cortex: implication for columnar resolution functional MRI, Neuroimage 30, 70-87 (2006).
R. Valabrègue, A. Aubert, J. Burger, J. Bittoun, and R. Costalat, Relation between cerebral blood flow and metabolism explained by a model of oxygen exchange, J Cereb Blood Flow Metab 23, 536-545 (2003).
K. Masamoto, T. Kim, M. Fukuda, P. Wang, and S. G. Kim, Relationship between neural, vascular, and BOLD signals in isoflurane-anesthetized rat somatosensory cortex, Cereb Cortex 17, 942-950 (2007).
I. G. Kassissia, C. A. Goresky, C. P. Rose, A. J. Schwab, A. Simard, P. M. Huet, and G. G. Bach, Tracer oxygen distribution is barrier-limited in the cerebral microcirculation, Circ Res 77, 1201-1211 (1995).
C. Y. Liu, S. G. Eskin, and J. D. Hellums, The oxygen permeability of cultured endothelial cell monolayers, Adv Exp Med Biol 345, 723-730 (1994).
T. Bär, The vascular system of the cerebral cortex, Adv Anat Embryol Cell Biol 59, 1-62 (1980).
P. S. Manoonkitiwongsa, P. J. McMillan, R. L. Schultz, C. Jackson-Friedman, and P. D. Lyden, A simple stereologic method for analysis of cerebral cortical microvessels using image analysis, Brain Res Brain Res Protoc 8, 45-57 (2001).
G. Pawlik, A. Rackl, and R. J. Bing, Quantitative capillary topography and blood flow in the cerebral cortex of cats: an in vivo microscopic study, Brain Res 208, 35-58 (1981).
T. Kim, K. S. Hendrich, K. Masamoto, and S. G. Kim, Arterial versus total blood volume changes during neural activity-induced cerebral blood flow change: implication for BOLD fMRI, J Cereb Blood Flow Metab 27, 1235-1247 (2007).
B. R. Duling, and R. M. Berne, Longitudinal gradients in periarteriolar oxygen tension. A possible mechanism for the participation of oxygen in local regulation of blood flow, Circ Res 27, 669-678 (1970).
E. Vovenko, Distribution of oxygen tension on the surface of arterioles, capillaries and venules of brain cortex and in tissue in normoxia: an experimental study on rats, Pflugers Arch 437, 617-623 (1999).
L. Kuo, and R. N. Pittman, Effect of hemodilution on oxygen transport in arteriolar networks of hamster striated muscle, Am J Physiol 254, H331-339 (1988).
M. Shibata, K. Qin, S. Ichioka, and A. Kamiya, Vascular wall energetics in arterioles during nitric oxidedependent and -independent vasodilation, J Appl Physiol 100, 1793-1798 (2006).
A. G. Tsai, B. Friesenecker, M. C. Mazzoni, H. Kerger, D. G. Buerk, P. C. Johnson, and M. Intaglietta, Microvascular and tissue oxygen gradients in the rat mesentery, Proc Natl Acad Sci USA 95, 6590-6595 (1998).
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Masamoto, K., Vazquez, A., Wang, P., Kim, SG. (2009). Brain Tissue Oxygen Consumption And Supply Induced By Neural Activation:. In: Liss, P., Hansell, P., Bruley, D.F., Harrison, D.K. (eds) Oxygen Transport to Tissue XXX. Advances in Experimental Medicine and Biology, vol 645. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-85998-9_43
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DOI: https://doi.org/10.1007/978-0-387-85998-9_43
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