The skin is the largest organ of the body, ranging in size from 1.5 to 2.0 m2 in adults [1]. This highly-organized composite structure fulfils a wide variety of functions critical to the maintenance of homeostasis [2]. Burns, caused by thermal, chemical, or electrical injuries, can result in severe and irreparable damage to the skin, leading to wound contracture, scar tissue formation, and a loss of functionality. In the United States, between 60,000 and 80,000 patients are hospitalized annually for the treatment of serious burns [3, 4]. The average cost of patient care, reconstruction, and rehabilitation is extremely high, especially in severe or extensive cases [5]. Improvements in resuscitation techniques now facilitate the survival of patients with major burns extending over more than 90% of their bodies [6].
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Flynn, L.E., Woodhouse, K.A. (2009). Burn Dressing Biomaterials and Tissue Engineering. In: Narayan, R. (eds) Biomedical Materials. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-84872-3_14
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