Abstract
Peripheral infection or inflammation influences behavior by interacting with neural systems in the periphery and central nervous system that mediate pain, arousal and behavior. Multiple parallel pathways convey information relevant to sickness behavior, local inflammation and pain. For instance, vagal sensory neurons seem to contribute to systemic, brain-mediated responses, whereas spinal viscerosensory nerves modulate local inflammation and pain. Neural pathways of immuneto- brain communication drive projection neurons in the brainstem that potently influence forebrain regions, including the paraventricular thalamus, much of the hypothalamus, the basal forebrain, amygdala and bed nucleus of the stria terminalis. Cortical components of the immune-responsive network include the anterior cingulate, medial prefrontal and insular cortices. This immune “sensory system” provides the means by which the brain can monitor peripheral immune challenges and carry out relevant behavioral responses.
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Goehler, L.E., Gaykema, R.P. (2009). Neural Pathways Mediating Behavioral Changes Associated with Immunological Challenge. In: Siegel, A., Zalcman, S.S. (eds) The Neuroimmunological Basis of Behavior and Mental Disorders. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-84851-8_3
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