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Effects of Anticoagulants on Cancer: Heparins

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Coagulation in Cancer

Part of the book series: Cancer Treatment and Research ((CTAR,volume 148))

The association of venous thrombosis and cancer has been recognized since the description by Armand Trousseau in 1865 [1]. In fact, Buller and colleagues have discovered an earlier report by Bouillaud in which he described three patients with cancer and deep vein thrombosis in 1823, some 42 years before the publication by Trousseau [2]. In the past two to three decades there has been increasing interest in the diagnosis, prevention, and treatment of venous thromboembolism associated with cancer [3]. The heparins [unfractionated heparin (UFH) and low molecular weight heparin (LMWH)] have proven efficacy and safety for the prevention of venous thromboembolism (VTE) in a wide variety of cancers including both solid tumors and hematologic malignancies.

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  1. University of Calgary, South Tower Foothills Hospital, Unit 1633, 1632 – 14th AVE NW, Calgary, Alberta, T2N 1M7, Canada

    Graham F. Pineo

  2. Thrombosis Research Unit, Foothills Hospital, 601 South Tower, 1403-29th Street NW, Calgary, Alberta, T2N 2T9, Canada

    Russell D. Hull

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    Pineo, G.F., Hull, R.D. (2009). Effects of Anticoagulants on Cancer: Heparins. In: Kwaan, H., Green, D. (eds) Coagulation in Cancer. Cancer Treatment and Research, vol 148. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-79962-9_15

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